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Biomedical subjects

J L Fox

Publications and source records attributed to J L Fox.

At least 397 records · Page 22Linked to original sources
PubMedDate not supplied

Microsurgical exposure of intracranial aneurysms.

The surgical anatomy of intracranial aneurysms as seen through the operating microscope is illustrated. The frontotemporal, or pterional, approach is used. The author demonstrates the teaching value of photographs of anatomic details as revealed in surgery.

Aneurysm, Ruptured↗
PubMedDate not supplied

The aberrant jugular bulb.

The aberrant jugular bulb has been found in 0.5-7.0% of autopsy cases. Its primary interest lies in the appreciation of its benignancy, its occasional symptomatic behavior and of the consequences of failing to glean its true nature of surgery. Therefore, the importance of proper preoperative diagnostic evaluation must be stressed so that operative interference with an anomalous but otherwise normal structure can be avoided.

Adult↗
PubMedDate not supplied

Immunochemical tests of acetylcholine receptor subunit models.

Acetylcholine receptors of fish electric organs and mammalian skeletal muscle comprise four structurally homologous glycoprotein subunits in the mole ratio alpha 2 beta gamma delta (refs 1-4). All four subunits have leader sequences and are exposed on both sides of the membrane. From amino acid sequencing, three groups have predicted that each subunit has four hydrophobic alpha-helical transmembranous domains. Because the N-terminus of each subunit is thought to remain on the extracellular surface after cleavage of the leader sequence, this model predicts that the N- and C- termini are both on the extracellular side. An alternative model proposed by two other groups predicts that there is, in addition, a fifth amphipathic transmembranous domain which would place the C-terminus on the cytoplasmic side. Here, using anti-subunit sera and monoclonal antibodies and their reaction with synthetic subunit peptides, we demonstrate that the C-terminus is in fact on the cytoplasmic surface. We also show that, contrary to other predictions, the most hydrophilic sequence on the extracellular domain of alpha-subunits is not the main immunogenic region.

Amino Acid Sequence↗