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Biomedical subjects

J L Fletcher

Publications and source records attributed to J L Fletcher.

49 records · Page 3Linked to original sources

Citrate anticoagulants for plateletpheresis.

In 112 plateletphereses done by the Haemonetics blood processor, the comparative effectiveness of ACD formula A, ACD formula B, and 2 per cent citrate in saline was evaluated. With respect to yields of platelets and white blood cells (e.g., lymphocytes), ACD-B was significantly better than the other two. Both ACD-B and 2 per cent citrate gave a much lower incidence of citrate reactions in the donors than were encountered with ACD-A.

Anticoagulants↗

Efficacy of cefazolin as a prophylactic antibiotic in head and neck surgery.

The rationale for use of perioperative shortterm prophylactic antibiotics in prevention of postoperative infection in major head and neck surgery was reviewed. Cefazolin and placebo were compared in 50 patients and results showed that short-term perioperative cefazolin was a useful adjunct in reduction of postoperative infection. Findings suggest perioperative antibiotics may be safely and effectively used to reduce postoperative morbidity from infection after surgical procedures in volving skin and mucosa of the upper aerodigestive tract.

Adult↗

Human immunodeficiency virus and the fetus.

About 2 percent of current cases of acquired immunodeficiency syndrome are among patients less than 13 years of age. When a woman infected by the human immunodeficiency virus (HIV) becomes pregnant, her neonate has approximately a 40 percent chance of becoming infected vertically in the perinatal period. Experience in detecting HIV-infected pregnant women and in diagnosing their affected neonates has been less than satisfactory. In this review, the epidemiology, pathogenesis, transmission, clinical manifestations, diagnosis, and treatment-prevention of perinatal HIV infection are discussed.

Adult↗