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Biomedical subjects

J L Fitzgerald

Publications and source records attributed to J L Fitzgerald.

17 recordsLinked to original sources
PubMed1992

Consequences of increasing alcohol availability: the Iowa experience revisited.

Before/after survey data were used to investigate the effect that a sudden and dramatic wine and spirits availability increase in Iowa might have had on heavy and problem drinker rates. Three state surveys representing the age 18+ non-institutionalized population of Iowa were conducted in 1985, 1986 and 1989. Neither previous sales analyses nor this survey data analysis support the Distribution of Consumption Prevention Model prediction that increased wine and spirits availability would produce significant and lasting consumption increases and, in turn, heavy drinker and problem drinker prevalence rate increases.

Adolescent↗
PubMed1992

Elderly vs. younger problem drinker 'treatment' and recovery experiences.

To address the question of whether or not elderly problem drinkers experience any treatment contact discrimination or recovery rate disadvantages, the programme utilization and recovery rate experiences of a representative sample of older and younger persons arrested for drinking and driving (OWI) in Iowa were compared. Subjects were interviewed by phone or mail shortly after their OWI arrest and then again approximately 12 months later. Younger persons (18-54 years old) were compared with elderly persons (55 and over and 65 and over). The elderly subjects were also dichotomized as early onset (at least one problem drinking indicator occurred prior to age 55) or late onset (all problem drinking indicators occurred at age 55 or later). The elderly were as likely as, or more likely than, their younger counterparts to make a treatment contact, to remain in treatment and to recover.

Adolescent↗
PubMed1992

Alcohol availability and consumption: Iowa sales data revisited.

Recent changes in Iowa liquor control laws ended the 51-year-old state alcohol monopoly distribution system and turned the sales of bottled wine and spirits over to the private sector. The resulting increase in the availability of these beverages provided a unique opportunity to study the relationship between increased wine and spirits availability and changes in their consumption. Time series analyses of monthly sales (apparent consumption) trends showed that the increased availability had no lasting impact on consumption.

Adult↗
PubMed1992

Elderly versus younger problem drinker profiles: do they indicate a need for special programs for the elderly?

To address the question, "Do elderly problem drinkers differ from younger ones and therefore might they need special treatment programs?", the descriptive profiles of a representative sample of older and younger persons arrested for drinking and driving in Iowa were compared. Subjects were interviewed by telephone or mail using a structured, clinical interview schedule that was designed to obtain a comprehensive self-report picture of the role of alcohol in their lives. Younger persons (18-54 years old) were compared with two overlapping elderly age groups (55 and over and 65 and over). The elderly subjects were also dichotomized as "early onset" (at least one problem-drinking indicator occurred prior to age 55) and "late onset" (all problem drinking indicators occurred at age 55 or later). Although there were several statistically significant (p < or = .01) differences between the elderly and younger problem drinkers, there was a much, or more, heterogeneity within the elderly groups as there were differences between the elderly and their younger counterparts. Also, the descriptive profile of these at-large elderly problem drinkers differed, depending on whether their alcohol abuse was early- or late-onset.

Adolescent↗
PubMed1991

Chronic cocaine treatment does not alter rat striatal D2 autoreceptor sensitivity to pergolide.

Rat superfused striatal slices, preloaded with [3H]dopamine, were electrically stimulated and the stimulation-induced outflow of radioactivity was taken as an index of dopamine release. In the presence of 10 microM nomifensine, exposure of striatal slices to unlabelled dopamine (0.3 microM) for 6 min prior to stimulation, significantly reduced stimulation-induced outflow. In contrast, a 21-min exposure to dopamine did not significantly alter stimulation-induced outflow. These results suggest that D2 receptors modulating dopamine release in the rat striatum may be rapidly desensitized in vitro. Rats were pretreated for 14 days with cocaine HCl (10 mg/kg/day i.p.) or saline. A progressive enhancement of locomotor activity in cocaine-treated rats over the pretreatment period compared to that in saline-treated rats indicated a behavioural sensitization to cocaine. The inhibitory effect of pergolide (1, 10 and 100 nM) on stimulation-induced outflow from striatal slices obtained from cocaine-pretreated rats was not different from that in slices obtained from saline-pretreated rats. Therefore no evidence was obtained for either a desensitization or a supersensitivity of striatal D2 autoreceptors by chronic cocaine administration.

Animals↗
PubMed1990

Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices.

The effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamine release were investigated in superfused slices of rat striatum and hippocampus. MDMA (10 microM) increased the resting release of radioactivity from slices incubated in [3H]dopamine, [3H]5-hydroxytryptamine or [3H]noradrenaline. These effects of MDMA (10 microM) were blocked by the neuronal uptake inhibitors, cocaine (10 microM), fluoxetine (1 microM) and desmethylimipramine (1 microM), respectively. MDMA (10 microM) enhanced the stimulation-induced efflux of radioactivity from slices incubated in [3H]noradrenaline but not from slices incubated in [3H]5-hydroxytryptamine or [3H]dopamine. These results demonstrate for the first time a direct noradrenaline-releasing action of MDMA and differential effects of MDMA on the stimulation-induced release of noradrenaline, dopamine and 5-hydroxytryptamine from rat superfused brain slices.

3,4-Methylenedioxyamphetamine↗
PubMed1990

Circumstances and consequences of falls experienced by a community population 70 years and over during a prospective study.

A sample of 761 subjects 70 years and over was drawn from general-practice records of a rural township. Each subject was assessed and followed for 1 year to determine the incidence of and factors related to falls. The fall rate (number of falls per 100 person-years) increased from 47 for those aged 70-74 years to 121 for those 80 years and over. There was no sex difference in fall rate but men were more likely than women to fall outside and at greater levels of activity. Twenty per cent of falls were associated with trips and slips but we found no evidence that inspection of homes and installation of safety features would have decreased the fall rate. Ten per cent of falls resulted in significant injury. Men who fell had an increased subsequent risk of death compared with those who did not fall (relative risk 3.2, 95% CI 1.7-6.0). Subsequent mortality was increased among women who fell but not to significant levels (relative risk 1.6, 95% CI 0.9-2.7).

Accidental Falls↗
PubMed1988

Falls, elderly women and the cold.

In a prospective study of falls in 761 subjects 70 years and over an increase in the rate of falls in winter was observed in women but not men. When the daily minimum temperature fell to 1 degrees C or less the relative risk of falling in women increased to 1.53 (95% confidence intervals 1.21-1.84). We discuss measures to decrease this seasonal increase in the rate of falls.

Accidental Falls↗
PubMed1987

Self-report validity issues.

Two possible sources of the substantial gap usually found between survey self-reported alcohol consumption estimates for a population and estimates based on official alcohol sales records are investigated. A measure of atypical heavy drinking is added to ordinary consumption commonly measured in surveys, and consumption by an adolescent (age 14-17) sample is added to that of the adult sample. The relationship between respondents' purchases and consumption during a 30-day period is also investigated. Personal interviews were completed with a random sample of 997 adults and 182 adolescents in Iowa during February-April 1985. Adding atypical drinking to ordinary drinking narrowed the sales-self-report gap more than did adding adolescent drinking, but a considerable gap remained. Self-reported purchases were closer to sales than was self-reported consumption. However, not all purchasers were drinkers and not all drinkers were purchasers, and the two were not highly correlated. The self-report validity issue, which remains unresolved, is apparently affected by many factors. Self-reports appear to be accurate enough for some purposes but not for others. Official alcohol sales (or purchase) records are not necessarily valid measures of alcohol consumption.

Adolescent↗
PubMed1986

Drinking frequency changes in selected contexts by season in Iowa, 1979-1980.

A panel of individuals was interviewed at three points in time so that both individual and aggregate drinking behavior changes could be investigated during a period of increasing beverage alcohol sales (winter to summer) and a subsequent period of decreasing sales (summer to winter). The seasonal drinking frequency changes in different places, with different companions and in different situations, were generally consistent with the proposition that existing drinking behaviors are quite stable over time (the stability proposition), and also with the proposition that alcohol consumption increases occur without any substitution of new drinking behaviors for existing drinking behaviors (the addition proposition). There was, however, evidence that drinking contexts changed with age and that new drinking behaviors were substituted for old drinking behaviors in some of the subpopulations studied. This suggests that it may be feasible to find ways to encourage the substitution of one kind of drinking behavior for another. Finally, although the results generally support the stability and addition propositions, it is not clear that these characteristics are either necessary or sufficient for increased per capita consumption to produce an increased rate of alcohol-related problems.

Adult↗
PubMed1985

An experimental test of telephone aftercare contacts with alcoholics.

Alcoholics from two hospital-based treatment centers participated in an experimental test of the effects of extended aftercare on inpatient recovery rates. At discharge from inpatient treatment, subjects were randomly assigned either to an experimental group scheduled to be called by a center counselor every 2 weeks for 1 year or to a control group that experienced only the usual treatment. Follow-up interviews conducted approximately 12 months after hospital discharge found that the experimental group had no higher recovery rates than the control group. There was weak evidence that the calls reduced the burden that alcoholics place on community control and service agencies. There was no evidence that either the phone calls were more effective for some patients than for others or that some kinds of phone calls were more effective than others. Although most subjects said they liked the calls, wanted them to continue and perceived them as "good treatment," only one subject gave the calls credit for helping him maintain sobriety.

Adult↗
PubMed1979

Rural vs urban problem drinker clients.

The rural (n = 636) and urban (n = 3,294) clients served by the outpatient alcoholism service centers of Iowa during 1973-1974 are compared. More similarities than differences are observed. The implications for intervention and rehabilitation strategies are discussed.

Alcoholism↗