[Recurrent pleural effusion in a 40-year-old male over a ten-year period].
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Adult↗
Biomedical subjects
J L Fischer
Publications and source records attributed to J L Fischer.
[Noninvasive assessment of an aortic bioprosthesis malfunction with Doppler echocardiography].
A 27-year-old patient with aortic stenosis received a Carpentier Edwards bioprosthesis and a reconstruction of the mitral valve, in 1978. With auscultation, M-mode and two-dimensional echocardiography, we diagnosed in 1985 a malfunction of the aortic prosthesis with restenosis, insufficiency and mitral insufficiency. A reliable qualitative and quantitative non-invasive assessment, however, was only possible with Doppler echocardiography. The velocity of blood flow over the aortic valve was measured with the continuous-wave Doppler technique; the aortic valve pressure gradient and the valve area were determined. The pulsed Doppler allowed a semi-quantitative evaluation of the severity of the aortic and mitral insufficiency. The intraoperative and pathological anatomical results confirmed the results from Doppler echocardiography: aortic valve prosthesis malfunction with restenosis and insufficiency and mild haemodynamically insignificant mitral valve insufficiency. The need for cardiac catheterization in patients with valvular heart disease and prosthesis is discussed.
Adult↗
[Not Available].
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Congenital Abnormalities↗
[Not Available].
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Congenital Abnormalities↗
[New aspects of classification, diagnosis and therapy of amyloidoses].
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Amyloid↗
[Typing of amyloidoses intra vitam by tissue biopsy using antibodies. Report on 2 patients].
The value of the immunohistochemical classification of amyloid-syndromes has been illustrated in two patients with generalized amyloidosis. Chemical types and exact diagnosis were recognized in biopsies (and later necropsies) using antisera against different purified amyloid fibril proteins and the indirect immunoperoxidase technique. The first case, originally diagnosed as "perireticular" amyloid, was diagnosed as "Ak-amyloidosis with kappa-Bence-Jones-proteinuria without apparent B-cell malignoma", the second case as "AA-amyloidosis reactive to periodic fever". The diagnosis and possible therapeutic measures are discussed in the light of the new classification of amyloid syndromes.
Aged↗
Compliance of insulin-dependent diabetics with a low-fat diet.
Compliance with medical therapy is widely researched yet unpredictable. When counseled by a dietitian to begin a low-fat (25%) diabetic diet, subjects significantly decreased fat intake but did not achieve the prescribed 25% fat level. The significantly lower fat intake after instruction identified the registered dietitian as an effective behavioral change agent. Six compliance predictors obtained at an initial interview accounted for 77% of the variance in compliance.
Adult↗
French embryology and the "mechanics of development" from 1887 to 1910: L. Chabry, Y. Delage & E. Bataillon.
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Animals↗
Chloride dependence of the HCO3 exit step in urinary acidification by the turtle bladder.
To characterize the efflux of HCO-3 across the basolateral membrane of the H+-secreting cells of the turtle bladder, we examined the effect of substitution of gluconate or methyl sulfate for Cl- on the rate of acidification (JH). JH was measured as the short-circuit current in bladders in which Na+ transport was abolished with 10(-4) M ouabain. In hemibladders bathed in normal Ringer solution (Cl- = 122 mM) JH was 44.9 microA. Substitution of the Cl- resulted in a marked reduction in JH (12.5 microA with gluconate and 7.5 microA with methyl sulfate). Addition of Cl- to the mucosal surface had no effect on JH. In contrast, serosal addition of Cl- restored JH to control. The apparent Km for Cl- in gluconate Ringer was 0.13 mM. Serosal furosemide (1 mM) inhibited JH by 55% in Cl- Ringer. We conclude that HCO-3 exit across the basolateral membrane of the H+-secreting cell occurs via a Cl-HCO3 exchanger that has a high affinity for chloride.
Animals↗
[Not Available].
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Academies and Institutes↗
Control of bioactive corticotropin release from the neuro-intermediate lobe of the rat pituitary in vitro.
The purpose of this study was to identify agents capable of regulating the release of biologically active ACTH from the isolated neuro-intermediate lobe of the rat pituitary. Agents found to be potent secretagogues included acetylcholine (100 mug/ml), hypothalamic stalk-median eminence extract (0.33 eq), arginine antidiuretic hormone (100 mU/ml) and serotonin (100 mug/ml). Lower doses of arginine antidiuretic hormone (5.5 mU/ml) and serotonin (2 mug/ml) were ineffective. Dopamine 2 and 5 mug/ml) inhibited the release of biologically active ACTH whereas norepinephrine (5 mug/ml) did not. Dexamethasone (0.25 mug/ml) did not alter the basal or stimulated release of ACTH from the isolated neuro-intermediate lobe in contrast to its effect on ACTH release from the isolated anterior pituitary. Similarly, the tripeptide, prolyl-leucyl-glycinamide, which has been reported by some to inhibit MSH release, had no effect on either the basal or stimulated release of ACTH. The data suggest that regulation of ACTH release from the neuro-intermediate lobe in vivo may involve both stimulatory (acetylcholine) and inhibitory (dopamine) inputs.
Acetylcholine↗
[Teratogenic effects of localized x-irradiation of branchial and aortic arches of chick embryos (author's transl)].
X-irradiation of branchial and aortic arches of 3 day old chick embryos is lethal in only a small number of cases (3-12,5%), but results in a high proportion (30-96%) of arterial malformations. The production of arterial anomalies is not random, but is related to the experimental method used and the function of the aortic arch with respect to the dynamics of circulation. Numerical and statistical studes, together with histological examination of the irradiated branchial and aortic arches, have revealed the importance of: the immediate environment of the aortic arch on its morphogenesis, the moment at which the teratogenic aggression occurs and the role of haemodynamics in the fate of the aortic arches. To explain aortic teratogenesis, we propose a hypothesis according to which all arterial anomalies are of morphogenetic origin. These anomalies can result in circulatory modifications which, in turn, cause new malformations.
Animals↗
Histological aspects of arterial abnormalities produced by X-irradiation of the aortic and branchial arches in the chick embryo.
Low dose X irradiations centred on one or two aortic and branchial arches of 3-day check embryos result in teratogenic effects on the arteries (21-92%) and in low mortality (4-12%). Histological studies of abnormal arteries show different structural malformations of the arterial wall: inorganized arterial fibres, abnormal intima, newly formed arterial tissue in arterial lumen, coalescence of two arteries. It is suggested that a disturbance at the aortic differentiation level results under our experimental conditions in the observed arterial abnormalities.
Animals↗
[A newt (Triturus helveticus) with black eyes].
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Animals↗
Hispanic and Anglo college women's risk factors for substance use and eating disorders.
This study investigated the role of temperament style (Novelty Seeking and Harm Avoidance) of Hispanic American and Anglo college women in moderating and mediating the relationship between family addiction/family functioning and offspring problem behaviors. The sample was comprised of 67 Hispanic American and 770 Anglo undergraduate women. Findings of this study indicate that the processes of risk that lead to substance use and eating disorders follow different routes for Hispanic American and Anglo women. Novelty Seeking and Harm Avoidance were found to be important factors in both moderating and mediating the effects of parental drinking and family dysfunction for both Hispanic and Anglo college women.
Adolescent↗
[The founding of the chair of comparative embryogeny at the Collège de France (1844)].
The first chair of embryology was founded in 1844 at the College de France. Yet the founding met with hostility. The first occupant Victor Coste (1807-1873) was imposed on the institution. The administrator-professors of the College de France criticized the governmental procedure. Some professors, such as Georges-Louis Duvernoy, made a stand against the appointment of the young embryologist. Duvenoy continued for several years to protest against Coste's teachings at the College of France. But Coste was tacked by De Blainville and eventually Flourens. Credit should be given to Coste for having introduced a scientific embryology in France. The history of the founding of the chair of comparative embryogeny at the College de France is here described by drawing mainly on an umpublished archival source.
Education, Graduate↗