Biomedical subjects

J L Finley

Publications and source records attributed to J L Finley.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Fine needle aspiration cytology of bronchioloalveolar-cell carcinoma of the lung.

The fine needle aspiration cytology features of twelve peripherally located bronchioloalveolar cell carcinomas of the lung diagnosed by fine needle aspiration biopsy are described. A spectrum of cytomorphologic changes was appreciated, including classic groups showing uniform malignant cells having prominent depth of focus with a lack of significant nuclear molding. Other cells showed features of atypical alveolar macrophages and bronchial-lining cells. The smears demonstrated malignant cells arranged along alveolar septae and possessing hobnail-shaped nuclei. Two cases had associated psammoma bodies, and one case demonstrated optically clear nuclei in the malignant cells. This series stresses the fine needle aspiration features that aid in the recognition of this specific lung neoplasm and its differentiation from benign reactive pulmonary lesions, other primary lung cancers and metastatic tumors.

Adenocarcinoma↗

PubMedDate not supplied

Ascitic fluid cytology in a case of metastatic malignant mixed mesodermal tumor of the ovary.

The cytologic features of the abdominal fluid from a patient with a malignant mixed mesodermal tumor (MMMT) of the ovary are presented. Both malignant epithelial and stromal elements were cytologically appreciated and confirmed by histologic examination. Other ovarian neoplasms that can present with malignant sarcomatous elements or mixed epithelial and sarcomatous elements are discussed; this case documents the importance of recognizing these features when staging patients with unusual ovarian neoplasms. To our knowledge, this is the first complete report of the ascitic fluid cytology of an MMMT of either ovarian or uterine origin.

Aged↗

PubMedDate not supplied

Collagenous spherulosis. Report of a case with diagnosis by fine needle aspiration biopsy with immunocytochemical and ultrastructural observations.

Collagenous spherulosis (CS) is a benign breast lesion usually seen in association with other benign proliferative processes in the breast. To the best of our knowledge, this is the second fine needle aspiration (FNA) cytologic report of CS and the first with corresponding immunocytochemical and ultrastructural studies performed on the subsequent biopsy material. Cytologically, the aspirate consisted of scattered, metachromatically staining hyaline globules seen best with Diff-Quik stain in intimate association with numerous groups of benign ductal cells some of which had a papillary configuration. The globules exhibited periodic acid-Schiff positivity. A subsequent excisional biopsy confirmed the cytologic impression and revealed a multifocal process of ductal papillomas and papillomatosis containing numerous eosinophilic spherules with morphologic features and histochemical staining reactions typical of CS. Electron microscopic and immunoperoxidase studies suggest the spherules to be composed predominantly of basement membrane proteins, specifically type IV collagen, laminin and fibronectin, and to be derived principally from myoepithelial cells. Although CS has been found primarily in benign breast lesions, it can be found in other organs and in association with both benign and malignant processes. The differential diagnosis of other breast lesions that can be confused with CS on FNA biopsy is presented.

Adult↗