Letter: Studies on lactams. XXIX. Synthesis of aza analogs of Cepham.
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Biomedical subjects
Publications and source records attributed to J L Fahey.
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In synchronized human lymphoid cell lines, production of immunoglobulins G and M is greatest during the late Gl and S phases of the cell cycle. Little immunoglobulin appears immediately before, during, and immediately after mitosis. The results indicate that transcription of immunoglobulin genes takes place during a limited part of the mitotic cycle.
Soluble preparations of HL-A alloantigens were separated by gel filtration into components having either the "LA" series or the "4" series of alloantigenic determinants. This separation may indicate that several different structural cistrons within the HL-A (locus) control the expression of these two series of determinants. The alternative possibility, in which one structural cistron with multiple mutational sites controls the synthesis of a single molecule cannot be excluded.
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