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J L Davin

Publications and source records attributed to J L Davin.

30 records · Page 2Linked to original sources

[Catabolism of glycine used in lavage solutions in urologic surgery. Apropos of a prospective study of 20 patients undergoing endourethral resection of the prostate].

A prospective study was carried out on 20 patients admitted for transurethral prostatic resection, measuring renal function, body hydratation and levels of glycine metabolic products. This study has shown that only the haematocrit measurement during surgery allowed the early and reliable recognition of resorption of the solution. High glycine levels after resorption were reduced by increasing urinary excretion of glycine, serine, creatinine and to a lesser extent, threonine. The increased production of oxalate, another elimination pathway, leads to a urinary saturation with consequent risk of lithogenesis. Furthermore, this hyperoxaluria may cause an intersticial nephropathy as do the other secondary hyperoxalurias, including Crohn's disease, bowel by-pass or xylitol intoxication.

Acute Kidney Injury↗

[Acute renal insufficiency following endourethral surgery with glycine irrigation].

The authors analyse a case of acute renal failure in an old patient after a TUR of the prostate. The involved mechanism seems to be a toxicity of the glycine solution. In case of severe "TUR syndrome" with important resorption of glycine, the glycine could be catabolysed in oxalate, creating an hyperoxalemia and hyperoxaluria. The high blood level of oxalates can be responsible of acute renal failure and anuria. The treatment is simple: hemodialysis is able to eliminate quickly (in one session) the oxalates from the renal tubules and to restore the renal function. Prospective studies will give us an idea of the propitious conditions for this pathology and for the prevention.

Acute Kidney Injury↗

[Recent urethral rupture. From diagnosis to treatment].

A retrospective study of 30 cases of rupture of the urethra treated over a period of 12 years showed that the membranous urethra was involved in 25 patients. Cases of partial rupture of the anterior urethra treated by transient urine bypass were excluded from the study. As a result of the only moderate results obtained before 1977, the following therapy was instituted for ruptures of the posterior urethra after that date: immediate insertion of a suprapubic bladder drain (percutaneous or surgical); visualization of bladder and urethra on the 5th day using the bladder catheter and retrograde urethrography; deferred emergency repair operation towards the 8th or 10th day for cases with a stable pelvis and absent vital lesions; delayed repair during the 3rd month for the other cases. Results were evaluated as good with respect to urethral permeability in 3 of the 6 cases of emergency repair, 10 of 12 patients receiving deferred emergency surgery and 11 of 12 cases of delayed operation. Only two cases of sexual impotency were noted among the last ten cases treated. The obvious procedure to be adopted whenever possible is therefore an end-to-end urethrography as a deferred emergency operation.

Emergencies↗

[The surgical treatment of vesico-ureteral reflux in adults. Apropos of 45 cases].

The authors report 45 cases of adult patients treated surgically for vesico-ureteral reflux. They describe the indications and the data provided by preoperative biological and radiological examinations. The most widely used surgical procedure is submucosal advancement, and the authors discuss various technical aspects of this technique. Analysis of the results shows an 89.5% success rate with follow-up periods of at least eighteen months.

Adult↗

[Refractory urinary incontinence].

The authors present 3 cases where the diagnosis of ectopic insertion of the ureter, responsible for incontinence, had been missed: -- 2 cases of refluxing urethral insertions, including 1 case of single ureter, -- 1 case of vaginal ectopic ureter with duplicity. The authors stress that an ectopic insertion of the ureter can be asymptomatic until adulthood when it may present as simply as urinary stress incontinence. The diagnosis is suggested by a history of incontinence developing since childhood, accompanied by radiological signs of pyeloureteric duplicity or a small atrophic kidney. When the diagnosis is missed, successive surgical treatments are bound to fail, while excision of the renal segment drained by the ectopic ureter results in cure.

Adult↗

[Use of a coagulum for the ablation of renal calculi (author's transl)].

The authors report an experiment using the cadaver kidney with a fibrin coagulum injected into the pelvis and calices in order to extract multiple calculi. They used a mixture of cryoprecipitated plasma and a combination of thrombin and calcium chloride. This mixture was made up immediately before use, and injected into the pyelocaliceal cavities using a small Foley catheter previously inserted into the renal pelvis. This catheter was used to empty completely the pyelocaliceal cavities of urine immediately before injection. Extraction via a pyelotomy incision was used to withdraw the compact mold which had imprisoned the stones. In 20 kidneys studied experimentally, removal of stones was complete in only 12. The authors blamed this on their initial technical inexperience. The limitations and advantages of the method are discussed.

Fibrin↗

[Conservative treatment of bladder cancers with radiotherapy and concurrent chemotherapy: results and perspectives].

Therapeutic strategies for muscle invasive bladder cancer are currently evolving. Transurethral surgery followed by concurrent chemotherapy and radiotherapy is the best treatment for patients not suitable for radical cystectomy. This conservative approach may be proposed for operable patients with similar survival than after cystectomy. Intermediate evaluation of response is necessary, as response is the more discriminant prognostic factor for local control. Non responders would be assigned for immediate cystectomy. Morbidity and results of salvage cystectomy are poorly evaluated and probably depending from time from initial treatment and dose of radiation.

Antineoplastic Combined Chemotherapy Protocols↗

[Coagulum technic for removal of kidney calix calculi].

Coagulum pyelolithotomy is a useful adjunct for the extraction of renal caluli. This article describes a simplified technique using cryoprecipitated plasma, thrombin and calcium chloride. The method has been tested in vitro with twenty cadaver kidneys filled with stones. The results are analyzed. The technique is of definite interest when performed under the conditions described. The excellent results for patients make it very valuable. The limitations and advantages of the technique are discussed.

Calcium Chloride↗