Biomedical subjects

J L Combs

Publications and source records attributed to J L Combs.

4 recordsLinked to original sources

PubMed1991

Diffuse unilateral subacute neuroretinitis.

The clinical syndrome of diffuse unilateral subacute neuroretinopathy (DUSN) has been characterised in its early and late stages. Different types of migrating worms in the subretinal and intraretinal space have been described as the cause of the clinical syndrome. We observed a patient with a long history of visual loss, vitritis, and a fundus of abnormal appearance where the worm was noted to migrate to different areas over the course of hours.

Adult↗

PubMed1990

Anterior segment ischemia: a complication of retinal detachment repair in a patient with sickle cell trait.

Anterior segment ischemia (ASI) is a dreaded complication of retinal detachment surgery particularly in patients with predisposing factors such as sickle cell disease. We report a case of ASI after scleral buckling in an otherwise healthy black patient with sickle cell trait. Conditions of relative hypoxia intraoperatively from either anesthesia or surgical manipulation may precipitate vasoocclusive phenomena in these normally asymptomatic patients. Since the incidence of sickle cell trait in the black population in the United States is 8.5%, we recommend these patients have a preoperative sickle test followed by hemoglobin electrophoresis with quantification if positive. The presence of sickle cell trait should alert the surgeon to the risk of ASI, and factors predisposing to hypoxia should be minimized when possible.

Anterior Eye Segment↗

PubMed1990

Cryptococcal choroiditis.

Two patients with acquired immune deficiency syndrome presented with headaches and fevers. A diagnosis of cryptococcal meningitis was made by lumbar puncture and elevated cryptococcal antigens. Complaints of decreased vision in both patients led to the diagnosis of optic disc edema and cryptococcal choroiditis with yellow-white choroidal infiltrates noted in both eyes of the two patients. Systemic treatment with amphotericin B and 5' flucytosine led to resolution of the choroidal infiltrates. Late visual acuity loss was believed to be secondary to optic atrophy.

Acquired Immunodeficiency Syndrome↗

PubMed1990

Combined hamartomas of the retinal pigment epithelium and retina.

Combined hamartomas of the retinal pigment epithelium (RPE) and retina are rare, benign lesions usually occurring in individuals with no underlying systemic abnormalities. The authors report two cases of combined hamartomas of the RPE and retina. In one case, combined macular hamartomas of the RPE and retina were present in a 5-month-old infant. This is the earliest reported case of bilateral macular involvement. In both patients, multiple cafe-au-lait spots were present, and the diagnosis of neurofibromatosis was considered. The authors suggest that combined hamartomas of the RPE and retina are congenital lesions and may be one of the ophthalmic manifestations of the phakomatoses.

Child↗