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Biomedical subjects

J L Chen

Publications and source records attributed to J L Chen.

At least 163 records · Page 9Linked to original sources
PubMed1988

Epidemiologic study of workers exposed to titanium dioxide.

The objective of this study was to determine whether workers exposed to titanium dioxide (TiO2) had significantly higher risks of lung cancer, chronic respiratory disease, pleural thickening/plaques, or pulmonary fibrosis than referent groups. A total of 1,576 employees exposed to TiO2 were observed from 1956 through 1985 for cancer and chronic respiratory disease incidence, and from 1935 through 1983 for mortality. A cross-sectional sample of 398 employees was evaluated for chest roentgenogram abnormalities. Cohort analyses suggested that the risks of developing lung cancer and other fatal respiratory diseases were no higher for TiO2-exposed employees than for the referent groups. Nested case-control analyses found no statistically significant associations between TiO2 exposure and risk of lung cancer, chronic respiratory disease, and chest roentgenogram abnormalities. No cases of pulmonary fibrosis were observed among TiO2-exposed employees.

Cohort Studies↗
PubMed1988

Cytotoxic, fungicidal nucleosides from blue green algae belonging to the Scytonemataceae.

Tubercidin, toyocamycin, and the corresponding 5'-alpha-D-glucopyranose derivatives of the nucleosides are frequently responsible for much of the cytotoxicity and antimycotic activity associated with extracts of cultured cyanophytes belonging to the family Scytonemataceae. The 5'-alpha-D-glucopyranoses of tubercidin and toyocamycin, for example, are the major cytotoxic and fungicidal nucleosides in Fijian Plectonema radiosum and Hawaiian Tolypothrix tenuis, respectively.

Antifungal Agents↗
PubMed1987

Residual fibrous masses in treated Hodgkin's disease.

Of nine patients with residual masses following therapy for Hodgkin's disease (HD), eight had nodular sclerosing HD, and one had mixed cellularity HD. One patient had Stage II disease, seven had Stage III, and one had Stage IV. Seven patients presented with bulky mediastinal disease. Regardless of the initial therapy used residual masses in the mediastinum and/or peripheral locations stabilized in 1 to 8 months. Between 5 and 10 months after initiation of therapy, five patients underwent resection of mediastinal or paratracheal masses; three patients had resection of peripheral masses, and one patient underwent laparatomy. Microscopically, the resected masses were hyalinized tissue showing a characteristic nodular configuration without evidence of active HD. Stable residual mass lesions occurring after therapy for HD should not be assumed to represent recalcitrant malignancy, as they may show only fibrosis.

Adolescent↗
PubMed1987

Cancer incidence and mortality among workers exposed to acrylonitrile.

A cohort of 1,083 male employees who had potential for exposure to acrylonitrile between 1944 and 1970 at a Du Pont textile fibers plant were followed through 1981 for mortality and through 1983 for cancer incidence. In total, the 21 cancer deaths were fewer than expected based on either Du Pont or U.S. rates. No significant excesses were seen by primary site. In all, 37 cancer cases occurred as compared with 36.5 expected based on company rates. Five lung cancer cases were observed and 6.9 expected. There were 5 prostate cancer cases as compared with 1.9 expected. Of these, 4 occurred among wage employees during the 1975-1983 period, compared to 0.9 expected. This excess was statistically significant.

Acrylonitrile↗
PubMed1987

Cancer incidence and mortality in the Du Pont Company: an update.

In a previous publication, Pell et al described the cancer epidemiologic surveillance program that was begun in the Du Pont Company in 1956 and presented standardized cancer incidence and mortality data through 1974 for Du Pont employees compared with such data for the US general population. This report provides the analysis of an additional 10 years of cancer incidence and mortality data, and examines time trends for specific cancer sites. Conoco, Inc, acquired in 1981, is not included in the analysis.

Adult↗
PubMed1985

Endometrial papillary adenocarcinomas: two clinicopathological types.

Thirty-four patients with primary endometrial papillary adenocarcinoma diagnosed in our institution from 1970 to 1982 were studied. Papillary adenocarcinomas represented 10% of all endometrial adenocarcinomas seen during this period. Papillary neoplasms were morphologically subclassified as either papillary serous adenocarcinoma or well-differentiated papillary adenocarcinoma, following review of the histological sections obtained prior to radiotherapy or chemotherapy. Twenty-five patients were found to have papillary serous adenocarcinoma, and nine had well-differentiated papillary adenocarcinoma. A control group of 305 patients with endometrial adenocarcinoma of nonpapillary type was compared with respect to age, race, and survival. Fifty percent of the patients with papillary serous adenocarcinoma were black and they were significantly older (p = 0.001) than the control group, with a mean age of 71 years. Thirty percent of the papillary serous adenocarcinoma group had deep myometrial invasion and peritoneal surface involvement by tumor. In 20% of these patients there was a discrepancy between the clinical stage and the surgical stage at laparotomy. Survival was markedly worse (p = 0.01) than that of the control group. Patients with well-differentiated papillary adenocarcinomas were similar to control patients with respect to age and racial status and had similar clinical survival outcome. We conclude that well-differentiated papillary adenocarcinoma of the endometrium is a distinct form of papillary adenocarcinoma, and must be morphologically and clinically distinguished from papillary serous adenocarcinomas because of its better prognosis. Morphological differentiation of these two papillary variants of endometrial adenocarcinoma is presented.

Adenocarcinoma, Papillary↗
PubMed1985

Epidemiologic study of workers exposed to acrylonitrile: an update.

A previous report presented the cancer morbidity and mortality experience through 1976 of a cohort of 1,345 male employees with potential for exposure to acrylonitrile at a fibers-producing plant. This study has now been updated through 1983 for cancer incidence and through 1981 for mortality. Overall, 43 cancer cases have occurred, with 37.1 expected based on company rates. A previously reported excess number of cases of lung cancer remains, but is not as marked (10 observed, 7.2 expected). Prostate cancer cases were significantly in excess, with six cases observed and 1.8 expected. Mortality analyses revealed 36 cancer deaths, with 31.6 expected. Of these, 14 were from lung cancer, with 11.6 expected based on company rates. Only one death from prostate cancer occurred, with 1.0 expected. To our knowledge, prostate cancer excesses have not been reported in any other acrylonitrile studies, and hence their significance is currently difficult to assess.

Acrylonitrile↗