During a 4-year period, 29 fetal nuchal edemas were observed, associated with other ultrasound abnormalities in 7 cases (24%). Fetal karyotypes were abnormal in 10 cases: 6 trisomy 21; 3 trisomy 18, and 1 Turner's syndrome. Isolated fetal nuchal edema was associated with aneuploidy in 4 cases: 3 trisomy 21, and 1 trisomy 18. The average age of the women carrying a fetus with nuchal edema associated or not with a trisomy 21 was 38.3 and 30.8 years, respectively. These results are similar to those found in the literature. It would appear that maternal age is a better marker in trisomy 21 screening than isolated fetal nuchal edema.

Adolescent↗

PubMedDate not supplied

Cytologic findings in a neovagina created with Vecchietti's technique for treating vaginal aplasia.

OBJECTIVE: To report long-term cytologic findings after treatment of congenital vaginal aplasia or Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) using progressive traction of the vulvar tissues, or Vecchietti's technique (VT). STUDY DESIGN: In eight women with MRKH, neovaginal smears stained by the Harris-Schorr technique were collected 2-12 years after VT. RESULTS: Eosinophilic superficial cells observed in all cases indicate that the neovaginal epithelium responds to hormonal variations. The presence of Döderlein bacilli (seven cases) suggests that the regional environment of the neovagina is almost the same as that of the normal vagina. Gardnerella vaginalis (one case) and human papilloma virus infection (low grade squamous intraepithelial lesions) (one case) were also observed. CONCLUSION: Neovaginal smears taken after the cicatrization period following construction of a neovagina by VT show a remarkable resemblance to those from normal vaginal mucosa and suggest that these neovaginas are almost the same as normal vaginas.

Adolescent↗

PubMedDate not supplied

Flow-volume curves in children in health and disease.

Pulmonary function studies were done in 136 children (5.5-17 yr old) of whom 39 had allergic type asthma, 26 chronic bronchorrhea, and 13 mucoviscidosis; the remaining 58 subjects were healthy. The children having respiratory problems were studied when they were clinically free from wheezing and pulmonary infection. Measurements of forced expiration were made with a pneumotachograph; the data were stored on a magnetic tape and analysed with a Hewlett-Packard programmed computer. Standards for the different ventilatory parameters were established for the healthy children. A step by step discriminant linear analysis of the data and application of the Kolmogorov-Smirnov test demonstrated that V25, V50 and MMEF measurements were the best discriminating parameters of pulmonary function abnormalities in the respiratory problem children.

Adolescent↗