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Biomedical subjects

J L Berry

Publications and source records attributed to J L Berry.

At least 73 records · Page 4Linked to original sources
PubMed1983

Familial hypocalciuric hypercalcaemia: observations on vitamin D metabolism and parathyroid function.

Serum vitamin D metabolites, the renal tubular maximum reabsorptive rate for phosphate (TMP/GFR) nephrogenic cyclic AMP (NcAMPI, and CaE (urinary calcium excretion per litre of glomerular filtrate) were measured in 14 adults with familial hypocalciuric hypercalcaemia (FHH). The findings were compared with analyses in 14 patients with surgically proven primary hyperparathyroidism matched for serum calcium, creatinine clearance and vitamin D status (assessed by serum concentrations of 25 hydroxyvitamin D). Vitamin D metabolites were also measured in 16 normocalcaemic relatives of patients with FHH. The serum concentration of 24,25 dihydroxycholecalciferol was appropriate for the prevailing 25 hydroxyvitamin D and no difference was found between groups. The serum concentration of 1,25 dihydroxycholecalciferol was significantly greater in primary hyperparathyroidism (P less than 0.0005) compared with patients with FHH and their normocalcaemic relatives. TMP/GFR was reduced in both primary hyperparathyroidism (0.53 +/- 0.12 mmol/l GF, mean +/- SEM) and FHH (0.86 +/- 0.14 mmol/l GF). Patients with primary hyperparathyroidism showed an increase in NcAMP output in the urine (38.5 +/- 16 mmol/l GF) which was significantly greater (P less than 0.0001) than the normal NcAMP (13.5 +/- 9.2 nmol/l GF) found in FHH. CaE was low in FHH indicating increased renal tubular reabsorption of calcium. It is concluded that there is no abnormality of vitamin D metabolism in FHH comparable with the changes observed in primary hyperparathyroidism. It is suggested that the biochemical abnormalities in FHH cannot be explained solely upon an increased sensitivity of the renal tubules to the effects of endogenous parathyroid hormone.

24,25-Dihydroxyvitamin D 3↗
PubMed1982

Observations on the natural history of vitamin D deficiency amongst Asian immigrants.

The Asian community of Rochdale was examined for evidence of vitamin D deficiency in 1970 and again in 1980. There has been a striking improvement in the biochemical markers of vitamin D deficiency among Asian children, but little improvement was observed in the adults. Asian children born in the United Kingdom had higher serum 25 hydroxyvitamin D concentrations than migrant children. Prolonged residence in the United Kingdom and a long period of exposure to western customs was not associated with a better vitamin D status in the adults. The vitamin D status of this community was still markedly inferior to that of a white control group despite attempts to influence their dietary practices and habitual solar exposure. Vitamin D deficiency presents a continuing problem among first generation adult migrants, but a decreasing problem among children.

25-Hydroxyvitamin D 2↗
PubMed1981

Annual high-dose vitamin D prophylaxis in Asian immigrants.

A group of vitamin-D-depleted Asians was identified in the spring of 1980 and treated with 2.5 mg ergocalciferol in the autumn of that year. Treatment produced a sustained rise in the serum level of 25-hydroxyvitamin D which lasted until the spring of 1981. The response was more predictable after oral than after intramuscular administration. Treatment in the autumn provides an effective, efficient, and cheap means of prophylaxis against vitamin D deficiency in Asians during the winter. A "once a year" regimen promises a much higher compliance rate than could be achieved by daily supplementation.

Administration, Oral↗
PubMed1981

Use of ultrasound biparietal diameter in timing of repeat cesarean section.

The aim of the study was to evaluate the use of ultrasound biparietal diameter (BPD) in the timing of elective repeat cesarean section on a large indigent service. One hundred sixty-five patients were evaluated over 2 years. If the BPD was 9.3 cm or more at or later than 38 weeks' gestation, a repeat procedure was undertaken without further testing of fetal maturity. This occurred in 55% of the study group. None of these neonates developed hyaline membrane disease (HMD). The remainder of the study group either did not attain a BPD of 9.3 cm by term, were diabetic, or had other factors to determine timing of delivery. Of this group, 50% underwent amniocentesis for a lecithin:sphingomyelin ratio. Three patients had fetal bleeding, 1 had rupture of membranes, and 1 began labor following amniocentesis. All neonates were healthy except 1 who had mild HMD. That neonate had not reached 9.3 cm BPD. Ultrasound has allowed development of a management program for elective repeat cesarean section that is reliable, cost-effective, and beneficial to the mother and neonate.

Cephalometry↗
PubMed1976

Interactions between antimigraine drugs and a high affinity uptake and storage mechanism for 5-hydroxytryptamine.

Rabbit hearts removed 3H-5-hydroxytryptamine (3H-5-HT) from a perfusion concentration of 2.6 X 10(-9) g/ml. 15.8% of the extractable cardiac total radioactivity consisted of metabolites, mainly 5-hydroxyindoleacetic acid, and metabolism appeared in the perfusion fluid during the course of the perfusion. Ergotamine tartrate (1.0 X 10(-6) g/ml) caused a small increase in 3H-5-HT uptake by the heart. Methysergide bimaleate (1.0 X 10(-6) g/ml) slowed the appearance of metabolites in the perfusion fluid. Because of the high concentrations required, neither observation seems likely to be of clinical significance to migraine. The results do, however, suggest that the frequently observed sensitisation of tissues to 5-HT by ergotamine and methysergide is not the result of inhibition of its tissue uptake.

Animals↗
PubMedDate not supplied

Lack of a role for cardiac sympathetic nerves in the uptake and metabolism of 3H-5-hydroxytryptamine by isolated rabbit hearts.

Perfused rabbit hearts removed 3H-5-hydroxytryptamine (3H-5-HT) from a perfusion solution containing 2.6 ng/ml and a tissue-to-medium ratio of about 10 was achieved after a 55 min perfusion period. 12.4 +/- 1.0% of the cardiac total radioactivity consisted of metabolites and metabolites appeared in the venous effluent during the course of the perfusion. Pretreatment of animals with 6-hydroxydopamine reduced cardiac noradrenaline concentrations by 92%, abolished the histochemical fluorescence characteristic of noradrenaline in sympathetic nerves and abolished the mechanical response to sympathetic nerve stimulation. In these hearts, the removal of 3H-5-HT from the perfusion fluid and the accumulation of total radioactivity was normal. There was, however, a significant increase in the proportion of the total cardiac radioactivity which was present as metabolites. The results suggest that the cardiac sympathetic nerves are not the site of 3H-5-HT uptake when the concentration in the perfusion medium is low. By analogy with work in the lung, it may be the endothelial cells of the coronary microcirculation which are responsible.

Animals↗