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Biomedical subjects

J Kwittken

Publications and source records attributed to J Kwittken.

At least 19 recordsLinked to original sources

Papular elastosis.

I report two typical cases of a cutaneous disorder caused by sunlight, which is common in Phoenix, Arizona, "The Valley of the Sun." It currently masquerades under the misnomer, adult colloid milium. It generally presents clinically as asymptomatic, shiny, smooth, firm papules, 1 to 10 mm in diameter, involving chronically sun-damaged skin of adults. The papules are generally multiple, but may be solitary, with various colorations. Microscopically, the papules all show severe elastosis involving most of the papillary cutis. It is most important to biopsy these lesions because clinically they may mimic a variety of skin lesions, some of which would require further investigations and therapy. This is a distinct clinical form of severe solar elastosis, which I propose to term papular elastosis.

Adult↗

Cutaneous melanocytic dysplasia and malignant melanoma. A critical review.

Melanocytic dysplasia refers not only to a variety of histologic changes, but is also a histologic diagnosis. Melanocytic dysplasia represents a diagnosis for those lesions in which the biologic potential cannot be determined. Histologic differences between a diagnosis of melanocytic dysplasia and malignant melanoma are detailed. The terms: borderline malignant melanoma or lesion, precancerous melanosis, active or activated nevus and atypical melanocytic hyperplasia should be abandoned. A differential diagnosis between in situ malignant melanoma and other melanin-containing in situ malignancies has been presented. All types of malignant melanoma which originate within the epidermis or epithelium have an in situ phase and show horizontal growth, and small early forms defy classification. The classification of the most common types of malignant melanoma has been revised. Although the level of invasion and tumor thickness are useful prognostic and therapeutic parameters, their determination is crude and subject to several shortcomings.

Diagnosis, Differential↗