[Hypothalamic hypophysiotropic hormones: biochemical and clinical aspects. I. Thyroliberin and luliberin].
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Biomedical subjects
Publications and source records attributed to J Kuska.
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In 12 patients with chronic hepatitis the carbohydrate tolerance and insulin secretion after intravenous and oral glucose loading were determined before and after lipostabil treatment. A significant rise of fasting insulinemia and hypersecretion of insulin after intravenous glucose loading were observed. After oral glucose loading the rise of insulinemia was significantly lower in patients than in healthy controls, despite a greater increase in glycemia. Administration of lipostabil for 2 weeks failed to exert any significant effect on carbohydrate intolerance and disturbances in insulin secretion, which were present in patients with chronic hepatitis.
In 19 patients with acute renal failure the plasma renin activity and aldosterone were determined in the phase of anuria and oliguria. A highly increased plasma renin activity was found while aldosteronemia was only moderately raised. No significant correlation was demonstrated between plasma renin activity and aldosterone while a negative correlation was found between aldosteronemia and plasma sodium and bicarbonates concentrations. Lack of significant correlation between plasma renin activity and aldosteronemia in cases of acute renal failure suggests that factors other than renin participate in the regulation of aldosterone secretion in these patients.
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