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Biomedical subjects

J Kuska

Publications and source records attributed to J Kuska.

At least 37 records · Page 2Linked to original sources
PubMed1986

Plasma concentrations of ketanserin in chronic hemodialysed patients.

Six patients on chronic hemodialysis received 20 mg ketanserin p.o. twice daily for 3 days. Plasma levels were measured daily 2 hours after application of the morning dose; however, on the third day, plasma levels were taken before, during and after dialysis. On the 4th day elimination was measured after a single dose of 20 mg ketanserin for 24 hours. Mean plasma levels ranged from 19 to 31 ng/ml. Both ketanserin and reduced ketanserin were not eliminated by dialysis. Elimination half-life was about 12 hours.

Adult↗
PubMed1984

[Effects of L-arginine on glucagon and insulin secretion in patients with acute kidney failure].

In 20 patients with acute renal failure and 11 normal persons the behaviour of the glucagon and insulin secretion was examined after administration of L-arginine. Under standard conditions the glucagon level was significantly higher in the acute renal insufficiency than in the normals. Increased glucagon levels could be stated in the anuric/oliguric as well as in the polyuric phase. After administration of L-arginine in the acute renal failure a significantly higher increase of the glucagon level, but a significantly lower increase of the insulin concentration could be observed than in healthy persons. On account of these findings apart from the endocrinological changes stated also other factors seem to be involved in the pathogenesis of the carbohydrate intolerance in acute renal insufficiency.

Acute Kidney Injury↗