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Biomedical subjects

J Kuikka

Publications and source records attributed to J Kuikka.

At least 91 records · Page 5Linked to original sources
PubMed1977

An intravenous isotope method for measuring regional cerebral blood flow (rCBF) and volume (rCBV).

The regional cerebral blood flow (rCBF), intial slope index (ISI), transfer time (th) and volume (rCBV) were measured simultaneously in 43 hospital patients using a 133Xe intravenous injection method and quantitative dynamic 99Tcm brain scintigraphy. The measurements were made with a gamma camera and the data processing interfaced with a small digital computer. The following mean values and standard deviations were obtained from 50 control hemispheres standardized to the age of 40 years: (formular): see article. Good agreement was found between the blood flow values determined from the intra-arterial and intravenous injection techniques.

Adolescent↗
PubMed1977

A simple and rapid non-invasive radioisotope method to determine ventricular ejection fractions and cardiopulmonary transit times.

Ejection fractions and cardiopulmonary transit times were measured in 20 hospital patients by means of intravenously injected 99mTc-radiocardiography. Time activity curves from the regions of the whole heart, superior vena cava, right atrium, right ventricle, right lung, left atrium and left ventricle were drawn and analyzed by using the modified gamma function fitting method. The comparison between the ejection fractions determined from the whole heart curves and those from the ventricular curves shows a correlation coefficient of 0.93 for the right ventricle and of 0.90 for the left, although there was a systematic difference between the determinations. The analysis of the single ventricular curves gave about 10% higher values than those obtained from the whole heart curves. The cardiopulmonary parameters measured from the whole heart curves for 16 normal subjects the following results gave: right ventricular ejection fraction=0.57+/-0.08 left ventricular ejection fraction=0.62+/-0.08 pulmonary mean transit time=6.1+/-1.1 heart-beats intracardiac mean transit time=10.5+/-1.8 heart-beats right/left ventricular volume=1.10+/-0.09 These values agree closely with the data accumulated using more elaborate methods. The method presented here is simple to perform, it is non-invasive, time-saving, inexpensive, easy to analyze and suitable for exercising subjects and for bed-side measurements. Data assembly and analysis are easily automated so that results are obtainable immediately after measurements.

Adult↗
PubMed1976

Measurement of intervillous and myometrial blood flow by an intravenous 133Xe method.

A new 'non-invasive' method for measuring intervillous and myometrial blood flow is presented. After 2 mCi of 133Xe in physiological saline was injected intravenously the patient held her breath for 20 seconds. The tracer entered the placenta as a short bolus and its removal was followed with a scintillation detector. Intervillous and myometrial blood flow per unit volume was calculated from the two-exponential curve. The mean +/-SD intervillous flow in normal pregnancy was 135+/-49 ml/minute/100 ml, the corresponding half time being 0-56+/-0-16 minutes. The myometrial flow was 7-7+/-2-5 ml/minute/100 g. The method gave reproducible results and took only 20 minutes to perform. The dose of radiation to the mother was less than 1 mrad.

Adolescent↗
PubMed1976

Regional blood flow in human tumours with special reference to the effect of radiotherapy.

Blood flow in 41 superficial tumour nodules, of which nine were lymphomas, nine anaplastic carcinomas and 23 differentiated malignomas was measured using the 133Xe-clearance method. The lymphomas showed statistically higher blood flow (38-4 ml./min/100 g) than anaplastic (11-4 ml./min/100 g) and differentiated tumours (13-7 ml./min/100 g). After one week of radiation treatment the mean blood flow in anaplastic carcinomas was higher than the initial value. After an interval following the end of the radiation treatment the circulation diminished significantly compared with that observed immediately at the end of radiotherapy. The size of the tumours did not correlate with the blood flow.

Humans↗
PubMed1976

Retention and extra-articular spread of intra-articularly injected 90Y silicate.

A study was performed on the retention and distribution of intra-articularly injected colloidal 90Y silicate in 7 patients with rheumatoid arthritis (8 knees). In 5 knees retention was complete within the limits of measuring accuracy, and in the remaining 3, 82-84% was retained. No radioactivity was detected in the liver and heart areas or in the blood samples. The cumulative urine activity was less than 1.8%. In the inguinal lymph nodes, activity was detectable %0.5-2%) in only 3 cases. We conclude that 90Y silicate is a safe radioactive agent for the treatment of knee effusions, provided the limb is strictly immobilized after the injection.

Arthritis, Rheumatoid↗
PubMed1975

Cardiopulmonary blood volumes at rest and during muscular exercise measured by 113mIn radiocardiography.

Cardiac output, stroke volume, right heart and left heart blood volume, pulmonary blood volume and pulmonary mean time were measured at rest and during muscular exercise in 14 healthy subjects in the supine position. The method used was 113mIn radiocardiography measured precordially with a single detector. The results were analyzed with a minicomputer by a modified gamma function fitting method. The increase in cardiac output during exercise was 140 per cent (p is less than 0.001). The stroke volume increased 15 per cent (p is less than 0.05) in subjects with heart rates less than 160 beats/min, and decreased in subjects with heart rates greater than or equal to 160 beats/min. The right heart blood volume decreased from 115 ml/m2 to 105 ml/m2 to 215 ml/m2 (5 per cent; p is less than 0.1) and the left heart blood volume decreased from 120 ml/m2 to 110 ml/m2 (5 per cent; p is less than 0.01). The total heart blood volume thus decreased from 235 ml/m2 (5 per cent; p is less than 0.05). The pulmonary blood volume showed a corresponding increase from 250 ml/m2 to 280 ml/m2 (12 per cent; p is less than 0.005), and the cardiopulmonary blood volume did not markedly change (485 ml/m2 and 495 ml/m2). Pulmonary mean time decreased from 5.0 s to 2.4 s (52 per cent; p is less than 0.001).

Adult↗
PubMed1975

Bone involvement.

Explore the source record for details and available documents.

Arthritis↗
PubMedDate not supplied

Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis.

Data obtained from animal and human brain imaging studies indicate that frontal cortex and medial temporal lobe are involved in experiencing and controlling fear and anxiety. We tested the hypothesis that benzodiazepine receptor binding is decreased in the left temporal pole and increased in the right prefrontal area among patients suffering from anxiety. We studied 10 drug-naive female patients with generalized anxiety disorder (GAD) and 10 age- and gender-matched healthy controls with MRI and with SPET by using a new (123)I-labelled specific benzodiazepine receptor radioligand, NNC 13-8241. Blindly analyzed results showed that the benzodiazepine receptor binding of [(123)I]NNC 13-8241 was significantly decreased in the left temporal pole among patients with GAD when compared with age- and sex-matched healthy controls. This hemispheric asymmetry was studied further with a fractal analysis of the SPET images. The fractal dimension of the left hemispheric benzodiazepine receptor binding in patients with GAD was significantly higher than that of controls (1.28 +/- 0.09 and 1.17 +/- 0.07, respectively), whereas the intercept was decreased by 43 +/- 23% reflecting more homogeneous cerebral benzodiazepine receptor density distribution in patients with GAD. The finding is analogous to the decreased heterogeneity of myocardial blood flow observed in patients with ischemic heart disease. The results are consistent with the general hypothesis that high regional heterogeneity of perfusion, metabolism and receptor density is necessary to maintain adaptation ability in the living organism.

Adult↗