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Biomedical subjects

J Kruszewski

Publications and source records attributed to J Kruszewski.

At least 19 recordsLinked to original sources
PubMed2001

[Occupational penicillin allergy as an example of chronic recurring anaphylaxis].

A case of anaphylactic shock which appeared in a nurse working at surgery room for many years, was described. The nurse was examined due to the anaphylactic attack at work (paroxysmal, idiopathic anaphylaxis). Among many factors the first of all occupational ones (exposure to disinfectants, latex and penicillin) were taken into consideration. Two minutes after the intradermal application of 2 units of crystalline penicillin the symptoms of anaphylaxis (including the shock) occurred. The problems of penicillin allergy in the aspect of skin tests, which make use of this antibiotic, were also described in the paper.

Adult↗
PubMed2000

[Simultaneous coronary artery bypass grafting on the beating heart without assisted circulation and radical modified Patey mastectomy--case report].

A case of 53-year-old female with unstable angina pectoris and primary right breast cancer is presented. Simultaneous operation including coronary artery bypass grafting and modified radical mastectomy was performed. On the beating heart coronary anastomoses were done without cardiopulmonary bypass (CPB) through median sternotomy (OPCABG). Immediately after OPCABG cancer operation was performed under stable hemodynamics without any bleeding tendency. There were neither perioperative nor postoperative complications noticed. Three months after operation adjuvant local radiotherapy was started. Concomitant surgical treatment seems to be safe and beneficial in carefully selected patients who have surgically correctable coronary artery disease and potentially curable breast cancer.

Anastomosis, Surgical↗
PubMed1996

[Use of thermographic methods for estimation of skin prick test results. II. Evaluation of skin prick test results with histamine solutions of different concentration using liquid crystal mixtures].

The aim of the study was to evaluate the usefulness of liquid crystal thermography in interpretation of skin prick tests with selected allergens and different solutions of histamine. The study group consisted of 35 young adults with indications for skin prick tests, and in whom skin tests with different solutions of histamine were also carried out (10 mg of histamine per 1 ml diluted to a concentration of 1:1, 1:10, 1:100). The skin reaction was assessed visually after 15 minutes, measuring flare and wheal diameter and utilizing the liquid crystal thermographic method--assessing the diameter of each colour green, blue, violet. For statistical purposes the area was also calculated. A correlation of each area was performed with the wheal and flare diameter. The area of the skin reaction was largest for both methods using the undiluted solution of histamine, the smallest using the 1:100 dilution. The liquid crystal thermographic method showed larger areas of skin lesions than those using only the visual method by analyzing the size of the wheal and flare. Due to this fact skin tests should be carried out at lest 9 cm apart from each other. The largest correlation was found between diameter of the flare and area of blue colour of the liquid crystal thermographic method (registering the temperature of 34.3 degrees C-36.3 degrees C). Using the thermographic method a joint temperature analysis of the wheal and flare lesions are performed. The results of this study correspond with the earlier, preliminary studies showing the usefulness of the liquid crystal thermographic method in assessing skin reactions to different allergens and histamine solutions.

Adolescent↗
PubMed1995

[Use of thermography methods for evaluating skin prick tests. I. Background temperature of area where skin prick tests are performed. Optimal color scale of temperature differences registered by liquid crystals and conditions of their use].

The aim of the study was to estimate the value in visualization of temperature gradients in assessing results of skin prick tests. The study group consisted of 10 patients suspected of having allergic diseases in whom skin prick tests were carried out. They were performed typically using the Bencard allergens kits. A positive control was performed using different solutions of histamine (10 mg/ml, 1 mg/ml, 0.1 mg/ml). The traditional method comprising of measurement of erythema, and whed was compared with visual thermography and open liquid crystal themography. The background temperature of typical areas chosen for skin prick tests were compared under condition of thermographic evaluation. The skin of the upper region of the back was chosen for uniform temperature background. Basing on the analysis of the background temperature and in areas of high reaction to histamine and allergens the temperature and in areas of high reaction to histamine and allergens the temperature gradient was calculated to be 2.2 degrees--2.5 degrees C. In order to visualize this gradient in composition of liquid crystals was made of a working range of 34.3 degrees--36.3 degrees C. Criteria for a correct thermographic evaluation of skin prick tests were established after studying the effect of manipulation of the area examined, local lowering of the temperature, use of cold solutions of allergens. Further studies are planned in order to assess the practical use of this thermographic analytical method.

Adult↗
PubMed1994

High serum levels of allergen specific IgG-4 (asIgG-4) for common food allergens in healthy blood donors.

High serum levels of asIgG-4 against common food allergens are found in many patients with symptoms suggesting food allergy. The same patients are frequently negative for allergen specific IgE (asIgE) against the same allergens. These data were frequently interpreted as suggestive of a role of asIgG-4 in food allergy. In order to evaluate this hypothesis we tested serum levels of asIgG-4 against food allergens in young blood donors without any signs or history of food allergy. Fifty young healthy male donors were evaluated. The serum levels of IgE, and asIgE and IgG-4 against 14 common food allergens were determined. The studies were carried out using commercially available 3M Diagnostics Systems kits. AsIgG-4 against food allergens were found in sera of 92% blood donors, and in 62% of these healthy persons the levels of asIgG-4 were higher than 10.0 micrograms/ml. In a small proportion of patients, high serum levels of IgE and asIgE against the same food and/or inhalant allergens were found. Common occurrence of asIgG-4 against food allergens in healthy persons (without any symptoms which could suggest allergy or food intolerance) argues against the possible participation of these antibodies in the pathogenesis of food allergy. It is possible that their occurrence is the result of immunization against food antigens (allergens). It remains to be resolved whether the presence of these antibodies represents an epiphenomenon or may have some other biological role.

Adolescent↗
PubMed1993

Allergen-specific IgG-4 in patients with atopic diseases of the respiratory tract.

Serum levels of total IgE, allergen-specific IgE (asIgE) and allergen-specific IgG-4 (asIgG-4) were measured in 194 patients in whom atopic disease of respiratory tract was suspected. The patients were divided into 8 groups based on the results of skin testing and sera levels of IgE and asIgE. Increase of the serum asIgG-4 level was observed in only 26 cases (13%), and occurred exclusively in patients with positive skin reactions to allergen(s) accompanied by increased serum levels of asIgE. In contrast, no significant elevation of serum asIgG-4 was found in non-atopic patients and in patients in whom skin testing and serologic evaluation did not yield conclusive results. These results argue against involvement of asIgG-4 antibodies in the pathogenesis of atopic diseases and against their function as sensitizer of target cell, analogous to the function of asIgE. In the present study elevated level of serum asIgG-4 was noted predominantly in asthmatic patients previously subjected to specific desensitization, that is to repeated exposure to antigen (allergen), which could induce specific antibody response. It is in agreement with the notion, that the appearance of asIgG-4 antibodies in sera of the patients under study is a consequence of the specific immunization, and not of atopy.

Adult↗
PubMed1993

[Complications in the respiratory tract from measles].

In the study and incidence of measles complications in the respiratory tract was analyzed in patients hospitalized in the Department of Infectious Diseases CSK WAM in 1972-1992 because of measles. In this period the (equal?) epidemiology of disease was observed in 1989/1990. In 17% hospitalized patients pharyngitis and/or pneumonia were observed as a typical complications of measles. High percentage of complications without consequences was probably connected with virus mechanism of infection.

Adolescent↗