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J Krkoska

Publications and source records attributed to J Krkoska.

17 recordsLinked to original sources
PubMed1999

[Changes in acid-base equilibrium, ventilation parameters and immunologic reactions in thoracoscopic operations].

In the thoracoscopic operations it is usually necessary to deflate completely the ipsilateral lung. The aim of this study was to determine changes of blood gases and alterations of immune response mediators during thoracoscopic surgery with one-lung ventilation OLV. In the study 38 patients were included undergoing thoracoscopic or video-assisted thoracic surgery. Arterial blood gases, respiratory parameters, heart rate, blood pressure were determined before one-lung ventilation, at the peak of operation and after finishing OLV. The circulatory cytokines IL-1 beta, IL-2, IL-6, IL-8, TNF-alpha, and reactive oxygen species (ROS) were measured before and after operation, 3 h, 24 h and 48 h after operation. The obtained variables were statistically evaluated. One-lung ventilation caused a significant increase of PaCO2 (from 4.69 +/- 0.67 to 5.91 +/- 0.87 kPa) which was accompanied by an adequate decrease of pH (7.455 +/- 0.033-7.368 +/- 0.037) and a number of patients developed respiratory acidosis (34%). There were no significant changes in levels of the investigated cytokines, only a mild increase of IL-6, IL-8 and TNF during first 24 h after operation was observed. The activity of ROS was highest at the end of the operation, but did not differ significantly from the start, but then decreased significantly for a period of 24 h. The authors conclude that the observed increase of carbon dioxide levels and decrease of pH had no impact on the fate of the patients. Thoracoscopic or VATS procedures were a minimal load for patients causing no significant changes of proinflammatory cytokines. The operations did not significantly elevate the activity of ROS.

Acid-Base Equilibrium↗
PubMed1978

The adaptive mandible: a product of the relative osteo-neural growth.

The growth interrelation existing between the developing brain and its bony case (with the brain representing the morphogenetically determining structure to the shape and size of which the neurocranial bony envelope is adapted) is to be conceived just as a special case of a general phenomenon, the osteo-neural relation, which works throughout the entire vertebrate body. The morphological manifestations of this relation may be disclosed in the axial as well as in the appendicular skeleton. In the present communication the osteo-neural concept is applied to the morphogenesis of the facial skeleton with special reference to the mandible. The more or less elongated shape of the mandible in various species of vertebrates depends on the phylogenetically established higher or lesser degree of growth potentiality of the mandibular nerve. With the increasing size of the brain in the course of hominization the growth-in-length capability of the mandibular nerve is (compensatorily?) decreased with corresponding shortening of the mandible and with appearance of the chin. The proposed interpretation is supported by a model experiment. The highly characteristic shortening and angulation of the lower beak which may be produced experimentally in the chick embryo by a great variety of teratogens, is related most probably to the same underlying mechanism, viz., to the primary inhibition of the highly susceptible neural growth with the secondary adaptive deformity of the beak. Pierre-Robin-Syndrome (cleft palate and micrognathia) may be readily explained by a growth insufficiency of the palatine and mandibular nerves.

Animals↗
PubMed1976

Morphogenesis of the spinal canal, normal and stenotic.

The closest formative developmental dependence of the axial skeleton upon the morphogenesis of the intraspinal nervous structures is reflected in the roentgen features of the individual vertebrae as well as of the vertebral column in its entirety. The vertebroneural developmental events are characterized by a steady relative decrease in size of the nervous structures (the first to be laid down and huge in the embryonic period) under a corresponding increase in size of the skeletogenic tissues. There exists experimental evidence that the maintenance of the necessary developmental balance between the two tissues, the bony and the skeletogenic, is a function of the nervous substance. The tight spinal canal appears to result from a failure of the latter neural function leading to overgrowth of the bony structures, viz., to massive vertebrae and laminae encroaching upon the neural contents. Morphogenesis of the normal and tight lumbar spinal canal is discussed with special reference to the developmental interrelations between the cauda equina complex and the lumbar vertebrae.

Constriction↗
PubMed1970

[Diastematomyelia].

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Abnormalities, Multiple↗