Biomedical subjects
Publications and source records attributed to J Kohout.
Cycloheximide, even in a dose of 0.25 mg/kg administered s.c. to rats stimulated by pancreozymin and secretin, inhibited lipase activity in pancreatic juice. Lipase activity in serum of control animals was inhibited by cycloheximide. The secretion of trypsin and chymotrypsin was also decreased.
We investigated 582 cases of sarcoidosis by the skin-window (Rebuck) method. The number of macrophages appearing in skin windows was significantly increased in 432 patients with sarcoidosis in the active phase. Further, increased numbers of macrophages in the windows were found in patients with a positive Kveim-Siltzbach test, high immunoglobulin levels, increased B lymphocytes, and decreased T lymphocytes. Passive transfer of delayed-type hypersensitivity was weaker and shorter in sarcoidosis patients with increased presence of macrophages than in healthy controls. A close correlation between high macrophage reactivity and the other sepcific immunological factors in sarcoidosis is suggested.
Six nuclear suppressors of the (poky) cytoplasmic mutant (sup-1, sup-3, sup-4, sup-5, sup-10, sup-14) have been obtained in Neurospora crassa. The sup genes suppress the slow growth phenotype of (poky), and alleviate, at least partially, the deficiency of cyanide sensitive respiratory activity in the mycelium of this cytoplasmic mutant. The six suppressors are nonallelic, suppress the phenotypic effects of (stp-Bl) in addition to (poky), but have no effect on the phenotype expression of the (mi-3) cytoplasmic mutant. On the basis of experimentally established molecular defects in (poky) and on the basis of hypothetical consideration, it is proposed that the sup mutations affect the structure and properties of mitochondrial ribosomal proteins.
The sarcoidosis of the kidney frequently shows little symptoms, but leads in more progredient stages to heaviest functional deficits and uremia. Beside this genuine sarcoidosis of the kidney a nephrocalcinosis caused by the often higher blood calcium level in sarcoidosis patients can occur. Its cardinal manifestation is a nephrolithiasis. Seldom in sarcoidosis patients a glomerulonephritis following to humoral immune reactions is appearing. A case of genuine sarcoidosis of the kidney with typical course and extended functional deficit, improved by intensive therapy with corticosteroids and immunosuppressiva is reported.
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