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J Kodama

Publications and source records attributed to J Kodama.

99 records · Page 6Linked to original sources
PubMed1975

[Characteristics of aggressive behavior induced by chronic administration of theophylline in rats].

In previous studies we reported that chronic administration of theophylline induced affective aggressive behavior in rats. The present study was designed to clarify characteristics of the aggressive behavior observed, and compare it with that in the olfactory bulbectomized and isolated rats. To measure aggressive behavior, the reflexive fighting test, the test for killing response to various objects and the aggressiveness rating test were used, and in addition, the open field test was employed to objectively measure emotionality. It was only the theophyllinized rats that assumed the fighting position not only during the electric shock period but also during the adaptation and sound shock periods. The theophyllinized pairs fought quicker and more frequently than did the other treated pairs. During a 3 min observation the percentage of mouse-killers was much higher among the theophyllinized group (62.5%) than among the other treated groups (the olfactory bulbectomized and the isolated groups increased mouse killing to 87.8% and 62.5%, respectively, though the theophyllinized group remained at 62.5%. The theophyllinized killers attacked constantly rat-pups and dead as well as live mice. In the open field test, rearing and ambulatory activities increased more in the olfactory bulbectomized group and decreased more in the isolated group than in controls, but no change was observed in the theophyllinized group. Defecation which has a negative correlation with aggressiveness decreased more only in the theophyllinized group than in the controls. Prior to treatment there was a positive correlation between the frequency of ambulation and that of rearing (r = 0.535, n=32, p less than 0.01).

Aggression↗
PubMedDate not supplied

Heparanase expression in both normal endometrium and endometrial cancer.

The aim of this study was to investigate the relationship between heparanase expression and prognostic factors in endometrial cancer, as well as the relationship between heparanase expression during phases of the normal endometrial cycle. Immunohistochemical analysis of 166 endometrial cancers and 34 normal endometria in various phases of growth was performed. The heparanase expression in the late-proliferative phase of normal endometria was found to be significantly higher than in either the early-proliferative or the secretory phases (P= .012 and P= .044, respectively). Heparanase expression was also significantly higher in endometrial cancer patients with tumors of an advanced FIGO stage (P= .0003) and high FIGO grade (P= .004) and with cancers showing either deep myometrial invasion (P= .023), lymph node metastasis (P= .006), lymphvascular space involvement (P= .048), or positive peritoneal cytology (P= .010). The disease-free and overall survival rates of patients with intense heparanase expression were significantly lower than those of patients with absent or moderate heparanase expression (P= .004 and P= .002, respectively). Heparanase may participate in normal endometrial remodeling and can serve as an indicator of the aggressive potential and poor prognosis of endometrial cancers.

Adult↗
PubMedDate not supplied

Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer.

We examined the expression of platelet-derived endothelial cell growth factor (PD-ECGF) mRNAs in 47 invasive cervical cancer tissues by semi-quantitative RT-PCR and addressed its association with clinicopathological features including microvessel density. Squamous cell carcinomas expressed higher levels of PD-ECGF mRNA than non-squamous cell carcinomas (P=0.014). We found no association between FIGO stage and levels of PD-ECGF mRNA. A subset of 31 patients with stage Ib-II cervical cancer underwent radical hysterectomy and pelvic lymphadenectomy. There were no significant differences in PD-ECGF mRNA levels with respect to tumor size, degree of stromal invasion, lymphvascular space involvement, parametrial involvement, vaginal involvement or lymph node metastasis among these patients. There was no correlation between microvessel density and the levels of PD-ECGF mRNA. These findings suggest that PD-ECGF expression is not associated with progression and metastasis of cervical cancer.

Disease Progression↗
PubMedDate not supplied

Macrophage infiltration and angiogenesis in endometrial cancer.

The aim of this study was to determine whether tumor-associated macrophages (TAMs) infiltration correlates with clinicopathological factors including microvessel, counts and clinical outcome in endometrial cancer. Overall 56 out of the 109 endometrial cancers (51.4%) expressed distinct tumor-associated macrophages infiltration in their tumor stroma. Tumor-associated macrophages infiltration was significantly high in tumors with deep myometrial invasion, high grade and elderly patients. Microvessel counts strongly correlated with tumor-associated macrophages infiltration in tumor stroma (p = 0.0002). However, tumor-associated macrophages infiltration was not a prognostic factor. In conclusion, tumor-associated macrophages may play a crucial role in the promotion of angiogenesis, but can not be used to prodict prognosis of patients with endometrial cancer.

Adult↗
PubMedDate not supplied

Thrombospondin-1 and -2 messenger RNA expression in epithelial ovarian tumor.

BACKGROUND: The role of thrombospondin (TSP) in tumor progression remains controversial. The association of TSP with clinicopathological features regarding prognostic significance was examined in patients with epithelial ovarian tumor. MATERIALS AND METHODS: Gene expression of TSP-1 and TSP-2 was assessed by reverse transcriptase-polymerase chain reaction in 6 borderline and 29 malignant epithelial ovarian tumors. RESULTS: TSP-1 mRNA expression was detected in 14 out of the 29 malignant epithelial ovarian tumors (48.3%), whereas TSP-2 mRNA expression was detected in 7 malignant epithelial ovarian tumors (24.1%). In contrast, no specimen from the borderline epithelial ovarian tumors expressed TSP mRNA. TSP-1 expression was significantly higher in tumors with advanced stage, massive ascites, positive peritoneal cytology and high grade. TSP-2 expression was significantly higher in tumors with massive ascites. Patients exhibiting TSP-1 and -2 mRNA expression demonstrated a markedly poorer prognosis than those lacking TSP-1 and -2 mRNA expression. CONCLUSION: These findings provide evidence that TSP expression may be associated with an aggressive phenotype in this class of neoplasm.

Adenocarcinoma, Clear Cell↗