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Biomedical subjects

J Kocsis

Publications and source records attributed to J Kocsis.

At least 37 records · Page 2Linked to original sources
PubMed1986

Patterns of melatonin rhythms in depression.

The nocturnal rise of melatonin in serum of humans is the result of endogenously released norepinephrine (NE) acting upon beta-adrenergic receptors of the pineal gland. As there is much interest in the possibility of there being changes in the function of beta-receptors in depressed patients, the nocturnal rise of melatonin was measured in depressives and healthy control subjects. In one study, multiple serum samples were taken between 4.30 p.m. to 7.30 a.m. in seven male depressed patients with melancholia and five healthy male control subjects. The melancholic patients had a significantly reduced nocturnal elevation of melatonin. In a separate study, serum samples were taken at 8 a.m. and 11 p.m. in melancholic depressives, non-melancholic depressives and healthy control subjects. The melancholic patients had a significantly lower concentration of melatonin at 11 p.m., but not at 9 a.m., than that measured in either the control subjects or the non-melancholic depressed patients. These results are similar to those found recently by several other groups of investigators. Further research is indicated to elucidate mechanism(s) responsible for this phenomenon.

Adult↗
PubMed1985

Mosaic Turner's syndrome and pituitary microadenoma.

A case of a 25-year-old woman with amenorrhoea-galactorrhoea syndrome and microprolactinoma is reported. The 45 XO/46 XX chromosome aberration did not cause complete ovarian failure. The presence of a pituitary microadenoma was demonstrated by thin layer pluridirectional x-ray tomography of the sella and the pathologically high prolactin reserve capacity of the pituitary. After the removal of the microprolactinoma and postoperative bromocriptine administration, regular menstrual bleeding occurred and the galactorrhoea disappeared. Some possible explanations of peripheral endocrine gland disorders accompanied by pituitary adenomas are discussed.

Adenoma↗
PubMed1985

Peripheral edema associated with trazodone: a report of ten cases.

Ten depressed patients treated with trazodone developed edema and weight gain that was promptly reversed by reduction or discontinuation of trazodone. This suggests a dose-dependent effect. None of the patients had an active medical problem that might predispose to edema formation. Summary data on all 10 cases and three case histories are presented to alert physicians to this side effect.

Adult↗
PubMed1984

Involutional melancholia revisited.

In this study, 31 patients with involutional-onset major depression had significantly more somatization and hypochondriasis and less loss of libido, guilt, suicidal intent, and family history of depression than 60 patients with an earlier onset. Regardless of age at onset, patients over age 50 had more agitation, initial insomnia, and hypochondriasis than those under 50. These findings suggest that clinical characteristics of patients with unipolar endogenous depression may be influenced by age at both onset and time of current episode. Although there is insufficient evidence to view involutional melancholia as a separate clinical entity, further research into the genetic and biochemical basis of late-onset depression is warranted.

Adult↗
PubMed1983

Management of hormone-secreting pituitary microadenomas.

Experience with 22 patients with pituitary microadenoma is discussed. The diagnosis was based on examination of the contour of the normally sized sella turcica by multidirectional thin-layer tomography, and measurement of the pituitary hormone reserve capacity. Of the patients 13 had a microprolactinoma and 9 a microsomatotropinoma; 13 were subjected to trans-sphenoidal microadenomectomy and 14 received drug treatment. The problems of diagnostics and the choice of therapy are discussed.

Adenoma↗
PubMed1983

[Effect of decreased blood flow in the liver on blood pressure and on the renin-angiotensin system of the rat].

The effect of reduced blood flow in the liver was studied in acute and chronic experiments on rats. 2 hours after partial constriction of the portal vein in anesthetized rats the mean blood pressure was lower and the plasma renin activity higher than in the control group. There was no relation between the two parameters. 20 weeks after partial constriction of the portal vein in unanesthetized animals the body weight, liver weight and serum albumin fraction were decreased, while the kidney weight was increased significantly and the heart weight insignificantly. The systolic blood pressure of these animals was found to be lower than that of the controls, and their blood pressure response to the i. v. administration of angiotensin II was also lower. In comparison with the control no significant differences were found in the blood renin and substrate levels. The natriuresis proved considerably lower in the animals with the partial constriction of the portal vein.

Animals↗
PubMed1981

Contribution of the depressive perspective to memory function in depression.

The authors used a story recall paradigm to elucidate some aspects of the memory problems of depressive patients. They compared 21 hospitalized depressed patients with a matched group of control subjects for recall of a theme story containing material with positive, negative, and neutral affective tones. The results indicated an overall deficit in the story recall of the depressed patients, most of which could be ascribed to a decrement in recall of the positive themes in the story. Recall of the negative and neutral themes remained intact. These results are consistent with the view that a depressive perspective contributes one component to the memory difficulties of depressed patients.

Adult↗
PubMed1980

Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: II. Methodology and data analysis.

A preceding paper has reviewed the history, background, and rationale for this collaborative effort exploring the biologic basis of the affective disorders. This paper details the "flow" of a subject through the experimental protocol, the instrumentation used to obtain the clinical and behavioural data, and the biologic methodologies employed in the analysis of the body fluids. Data management and analysis techniques developed for this study are also examined.

Adrenocorticotropic Hormone↗
PubMed1980

Memory deficits in depression: evidence utilizing the Wechsler Memory Scale.

The performance of 21 hospitalized depressed patients was compared to a matched group of 21 controls on the Wechaler Memory Scale. The depressed patients showed deficits on Mental Control, Verbal Learning, and Visual Reproduction tasks, which indicate impairment of memory functions in depression. There may be a deficit in the attention and alerting mechanism of depressed patients.

Adult↗