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Biomedical subjects

J Kocemba

Publications and source records attributed to J Kocemba.

At least 19 recordsLinked to original sources
PubMed1995

Prevalence of autoantibodies in the very elderly: association with symptoms of ischemic heart disease.

The mechanisms leading to the increased expression of autoantibodies in the elderly are poorly understood. The aim of this study was to investigate whether the presence of ischemic heart disease (IHD) is associated with the prevalence of autoantibodies in the elderly over 85 years of age. Anti-nuclear (ANA), anti-smooth muscle (SMA), anti-mitochondrial (AMA), thyroid anti-microsomal autoantibodies (anti-Tg) and antibodies to gastric parietal cells (PCA) were determined in selected groups of healthy subjects and patients with IHD. In IHD patients, the following autoantibodies were detected: ANA in 42.1% of subjects, SMA in 10.5%, AMA in 5.3%, anti-Tg in 5.3%, and PCA in 5.3%. In control healthy subjects, ANA were detected in 10%, AMA in 5%, and PCA in 15%. In conclusion, autoantibodies were more common in patients with IHD than in control healthy subjects, but no significant differences were found.

Aged↗
PubMed1994

Influence of long-term treatment with nifedipine on blood pressure, left ventricular mass and cardiac arrhythmias in elderly hypertensive patients.

To determine the benefits of the long-term monotherapy with nifedipine in the elderly hypertensive patients, 100 subjects > 60 years old were included to the trial. Therapeutic efficacy of nifedipine was confirmed in 69% of the patients and resulted in reduction of SBP by 20.9% and DBP by 19.0% of their initial values, from 179.7/101.3 to 142.1/82.9 mmHg (p < 0.001). On the other hand, the range of circadian changes in systolic and diastolic BM did not decrease (67.1 and 37.0 mmHg before treatment and 65.0 and 36.2 mmHg at the end of the trial). Although cardiac output and ejection fraction significantly improved, the patients showed neither a significant reduction of left ventricular mass (313.6 g before and 282.4 g after therapy) nor a decrease in cardiac arrhythmias. Usefulness of long-term monotherapy with nifedipine in elderly patients is diminished by side-effects (11%), as well as a preserved high circadian BP variability and the unchanged left ventricular morphology that may result in persistent cardiac arrhythmias despite of the significant fall in BP.

Aged↗
PubMed1994

[Rhythm and conduction disorders among the adult population. Epidemiologic data].

2.487 resting ECG were examined which is 61.3% of randomly chosen group of inhabitants of Cracow, aged from 20 to 93. There were: sinus tachycardia (HR 100)--4.2%, extrasystole--2.7%, fibrillatio atriorum 1.4%, blocks A-VI0--0.9%, intraventricular conduction defects--3.6% (most often LAH). Prevalence of disturbances of rhythm and conduction increases with age, mainly after 60.

Adult↗
PubMed1990

Ventricular arrhythmias and echocardiographic parameters of the left ventricular morphology in elderly patients with arterial hypertension.

An analysis of cardiac arrhythmias in relation to left ventricular morphology and function was performed in 68 hypertensive patients 60 to 83 years of age. The study comprised Holter monitoring and echocardiography. Our results suggest that in elderly patients with primary arterial hypertension a correlation exists between left ventricular mass and the incidence of ventricular arrhythmias but not between left ventricular mass and supraventricular arrhythmias.

Aged↗
PubMed1990

[Electrocardiography in elderly inhabitants of Krakow. Epidemiological study].

The electrocardiographic records were performed in the randomly chosen area of Cracow. The results were obtained from 512 persons (153 M and 359 F) aged 70-93 years. Normal electrocardiograms observed in 25.4% of the studied population. The prevalence of electrocardiographic abnormalities was as follows: ST segment depression--40.0%, patterns of infarction--17.2% and left ventricular hypertrophy--10.4%. On the contrary right axis deviation, bradycardia, sinus arrest, II and III of a-v blocks were rarely observed. The prevalence of electrocardiographic abnormalities in the aged in Cracow is in the accordance with the findings observed in the countries with high risk of cardiovascular diseases.

Aged↗
PubMed1990

Long-term study of borderline hypertension among male industrial workers.

Out of 1,236 men aged 40-59 years working in the same industrial plant, 253 (20.5%) had borderline arterial hypertension (BH). These employees and 237 matched normotensives were followed for several years. After 13 years, 343 participants, 70% of the initial number were studied. Arterial hypertension developed in 79.1% of the group with initial BH, most frequently in those with systolic-diastolic, and less often with systolic or diastolic BH. In normotensives, hypertension was diagnosed in 30.0% (P less than 0.001). All participants showed a correlation between blood pressure rise and initial value. A smaller number of men in the group with initial BH (36%) continued to work compared with normotensive men (48.1%) (P less than 0.01). The relationship between ability to work and blood pressure level became more prominent when we took into account final diagnosis: 65.7% of the actual normotensives, 56.4% of the borderline hypertensives and 47.5% of the hypertensives were still working after 13 years. Death rate was also higher in the group with BH (15.4%) than in the controls (8.4%) (P less than 0.01). The highest death rate was found when BH was combined with other coronary risk factors.

Adult↗
PubMed1990

Acute and long-term treatment of hypertension with nifedipine in the elderly.

The acute hypotensive effect of nifedipine was evaluated, and the possibility of its long-term use in hypertensives over 60 years of age was studied. Sublingual nifedipine in a dose of 20 mg was given to 28 patients, mean age 73.1 yrs, and blood pressure, heart rate, and plasma drug concentration were monitored at 15 min, and every 30 min thereafter for 3 hrs. Systolic and diastolic blood pressure decreased at 15 min by 22.1 and 7.0 mmHg, respectively, reaching a maximal decrease two hours after drug administration. The decrease in blood pressure level did not correlate with nifedipine plasma concentration, but only with the initial systolic blood pressure. Long-term treatment with nifedipine was initiated in 60 patients, with 45 patients completing the study. Mean age was 66.2 years. An initial dose of 30 mg daily had to be increased to 60-80 mg in one-third of the patients. Monotherapy was not satisfactory in some patients. Blood pressure gradually decreased from 173/99 to 148/85 mmHg at three months, and to 141/84 mmHg at six months. Drug tolerance was fairly good. Nifedipine was withdrawn due to a considerable increase in heart rate in three patients and skin allergy in one. The most frequent adverse symptoms were: rash, headache, and leg oedema. Laboratory tests revealed no changes in urea and creatinine, and an increase in fasting glycaemia. Lipid parameters did not change significantly. These data proved that a single dose of 20 mg of nifedipine produced therapeutic plasma concentration of the drug and good hypotensive effect, positively correlating with initial systolic blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Sublingual↗
PubMed1989

[Nifedipine level in the blood and its immediate hypotensive effect after its sublingual administration to aged patients].

In 28 aged patients (means = 73.1 years) with arterial hypertension nifedipine has been administered sublingually in a single dose of 20 mg and the hypotensive effect of that drug under the control of its concentration in the blood serum was evaluated. The nifedipine concentration was determined by the use of gas chromatography with electron capture detector. The mean drug concentration increased from 38.1 ng/ml to 82.3 ng/l during the 2nd hour of observation. After 3 hours the lowering of the nifedipine concentration and the decrease of its hypotensive effect was observed. After 15 min from the drug application the systolic pressure lowered by the average 22.1 mmHg whereas the diastolic pressure was 7.0 mmHg lower. The most significant pressure decrease (mean of systolic pressure 52.7 mmHg) 7.03 kPa and that of diastolic pressure 23.2 mmHg (3.1 kPa) occurred after 2 and 1.5 hours. The decrease of pressures after nifedipine correlated with the start-point value of systolic pressure. The frequency of the heart action in the whole group did not altered significantly, however, in individual cases both the acceleration of that action (34 per min) or acceleration (42 systoles per min) was noted. Slight typical side-effects were noted in 5 treated patients. A single-dose sublingual 20 mg nifedipine (Cordafen--Polfa) administration enabled in all the subjects the obtaining of therapeutic drug level in the blood and in the aged patients with hypertension may be regarded as efficacious antihypertensive treatment.

Administration, Sublingual↗