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Biomedical subjects

J Knox

Publications and source records attributed to J Knox.

At least 19 recordsLinked to original sources
PubMed2001

An evaluation of the quality of orthodontic attachment offered by single- and double-mesh bracket bases using the finite element method of stress analysis.

The objective of this study was to evaluate the influence of bracket base mesh geometry on the stresses generated in the bracket-cement-tooth continuum by a shear/peel load case. A validated three-dimensional finite element model of the bracket-cement-tooth system was constructed consisting of 15,324 nodes and 2971 finite elements. Cement geometric and physical properties were held constant and bracket base geometry was varied, representing a variety of single-mesh configurations and 1 double-mesh design. For the single-mesh designs, increasing wire diameter (100-400 microm) resulted in a decrease in enamel and cement stresses. Increases in wire mesh spacing (200-750 microm) increased the major principal stress recorded in the enamel and adhesive at all wire diameters. Within the bracket, the major principal stress increased significantly at wire spacing above 400-500 microm. However, within the impregnated wire mesh (IWM), the major principal stress decreased as wire space increased. When the double-mesh bracket base was considered, the combined mesh layers resulted in a decrease in the stresses recorded in the most superficial (coarse) mesh layer and an increase in the stresses recorded in the deepest (fine mesh) layer when compared with the single-layer designs in isolation. Modification of single-mesh spacing and wire diameter influences the magnitude and distribution of stresses within the bracket-cement-tooth continuum. The use of a double-mesh design results in a reduction in the stresses recorded in the most superficial mesh. Mesh design influenced stress distribution in this study, primarily by determining the flexibility of the bracket base.

Bicuspid↗
PubMed2001

An evaluation of the influence of orthodontic adhesive on the stresses generated in a bonded bracket finite element model.

The objective of this study was to evaluate the stresses generated in the bracket-cement-tooth continuum by a tensile load case when the physical and geometric properties of cement are varied. A 2-stage approach was used. In the first stage, a validated 3-dimensional finite element model of the bracket-cement-tooth system was constructed that consisted of 15,324 nodes and 2971 finite elements. Bracket base geometry was held constant; the physical properties (elastic modulus; Poisson's ratio) and geometry (lute thickness) of the cement varied. A simplified 2-dimensional model was then developed to investigate the localized effects of the cement lute thickness and the shape of the lute periphery on the stress distribution in the system. Small increases in stress were recorded under load within the cement as the rigidity of the cement increased. Similarly, Poisson's ratio values above 0.4 appeared to have a small influence on the major principal stresses in the impregnated wire mesh layer when a tensile force was applied. Variation in lute thickness was shown to have an influence on the distribution of major principal stresses within the cement lute. Increased stresses were recorded at the lute periphery as the lute dimensions increased. The morphologic features of the lute periphery also appeared to have had a significant effect on the performance of an orthodontic adhesive. Acute cement-enamel angles resulted in an increased chance of singularity development and attachment failure. The physical properties and thickness of the cement lute and the shape of the cement lute periphery contribute to the stress distribution within the bracket-cement-tooth continuum and, therefore, the quality of orthodontic attachment provided.

Adhesives↗
PubMed2001

A validated finite element method study of orthodontic tooth movement in the human subject.

The aim of the study was to develop a 3D computer model of the movement of a maxillary incisor tooth when subjected to an orthodontic load. A novel method was to be developed to directly and accurately measure orthodontic tooth movement in a group of human volunteers. This was to be used to validate the finite element-based computer model. The design took the form of a prospective experiment at a laboratory at the University of Wales in 1996/7. A laser apparatus was used to sample tooth movement every 0.01 seconds over a 1-minute cycle for 10 healthy volunteers, whilst a constant 0.39 N load was applied. This process was repeated on eight separate occasions and the most consistent five readings taken for each subject. Data were used to calculate the physical properties of the periodontal ligament (PDL). The data gleaned by this method were used to validate the 3D FEM model. This was formed of 15,000 four-noded tetrahedral elements. Tooth displacements ranged from 0.012 to 0.133 mm. An appropriate elastic modulus of 1 N/mm(2) and Poisson's Ratio of 0.45 was derived for the PDL. Strain analysis, using the model, suggested that a maximum PDL strain of 4.77 x 10(-3) was recorded at the alveolar crest, while the largest apical strain recorded was 1.55 x 10(-3). The maximum strains recorded in the surrounding alveolar bone were 35 times less than for the PDL. A novel method for direct measurement of PDL physical properties in the human subject has been developed. The validated FEM model lends further evidence that the PDL is the main mediator of orthodontic tooth movement.

Adult↗
PubMed2000

A finite element analysis of the stress at the restoration-tooth interface, comparing inlays and bulk fillings.

A finite element investigation comparing bonded inlays and directly placed restorations is presented. The stress build-up due to the contraction of the restorative composite and the composite luting cement was computed using a finite element model accounting for the time-dependent, elasto-visco-plastic behaviour of the composite. In addition, the stresses generated in the restoration due to occlusal loading were computed. It was found that inlays, in general, generate higher stresses during curing, particularly along the interface between the cement and the dentine at the base of the cavity. This is probably due to a reduced capacity for stress relief through viscous flow during the early stages of the curing reaction. Under occlusal load, restorations placed using both techniques perform similarly, from a purely mechanical point of view.

Dental Caries↗
PubMed2000

Computation of the elastic properties of a resin impregnated wire mesh by the means of a homogenisation procedure.

The present paper presents a homogenisation technique applied to the problem of calculating equivalent material properties of a resin impregnated wire mesh. Although this type of material can be expected to possess, in general, a four-fold axis of rotational symmetry, it was found that a transversally isotropic model approximates the material behaviour to within 3.5%. It is therefore concluded that a transversally isotropic model is adequate for representing the resin impregnated mesh in structural calculations.

Coated Materials, Biocompatible↗
PubMed2000

The influence of orthodontic adhesive properties on the quality of orthodontic attachment.

The objective of this study was to determine the resilience, glass transition temperature (Tg), ultimate flexural strength (UFS), and penetration coefficient of 3 composite adhesives (Concise, Transbond, and Right On) and a glass ionomer cement (Fuji Ortho LC). For 25 minutes after initial set, the composite materials were significantly more resilient than Fuji Ortho LC (P = .000). Resilience values for all materials increased for up to 90 minutes after initial set, reflecting a continuation of their setting reaction. Right On remained the most resilient material at 90 minutes after initial set (P < or = .01). At 120 minutes, there was no significant difference in the resilience of Concise, Right On, and Fuji Ortho LC. However, Transbond was significantly less resilient than these materials (P < or = .01). The composite materials recorded significantly higher glass transition values (89-123 degrees C) than Fuji Ortho LC (54 degrees C). The composite materials were also significantly stronger (61-68 MPa) than Fuji Ortho LC (35 MPa) in flexion. The penetration coefficients of Concise and Transbond were significantly higher (P < or = .001) than Right On and Fuji Ortho LC. However, the relative penetration coefficients of the materials studied did not appear to influence the degree of bracket base penetration achieved by the cements. In conclusion, Fuji Ortho LC offered a reduced energy-absorbing capacity immediately after bracket placement and reduced cohesive and mechanical adhesive strength. In addition, the glass transition temperature of Fuji Ortho LC was low; this may result in compromised attachment at temperatures above 60 degrees C. Significant differences in the penetration coefficient of the materials studied have been recorded. However, the penetration of the 4 cements into a range of bracket base morphologies was uniformly good. Therefore, the differences in penetration coefficient recorded should not influence the quality of the bracket cement interface provided.

Acrylic Resins↗
PubMed2000

An evaluation of the stresses generated in a bonded orthodontic attachment by three different load cases using the Finite Element Method of stress analysis.

The objective of the investigation was to develop a clinically valid three-dimensional computer model of the orthodontic bracket-cement-tooth continuum, and determine the magnitude and distribution of stresses generated by three different load cases. A three-dimensional finite element model of the bracket-cement-tooth system was constructed consisting of 15,324 nodes and 2,971 finite elements. The stresses induced in the bracket-tooth interface by a masticatory load, a peel force and a twisting couple were recorded. The maximum principal stresses resulting from occlusal and 'twisting' forces are distributed toward the lute periphery. Peel forces, applied to the bracket tie wing, are concentrated beneath the bracket stem. Twisting forces result in the highest enamel stresses. The quality of orthodontic attachment can be explained by the magnitude and distribution of major principal stresses within the cement and impregnated bracket base. Shear and shear/peel forces are most likely to induce crack propagation within the adhesive layer. However, when a twisting action is used to remove orthodontic brackets, enamel failure is most likely. A clearer insight into the complexity of the bracket-cement-tooth system has been provided by numerical and finite element investigations. Further investigations, evaluating the influence of bracket base designs and orthodontic cement physical and geometric properties are indicated. Refereed Scientific Paper

Compressive Strength↗
PubMed2000

The influence of bracket base design on the strength of the bracket-cement interface.

The objectives of the study were to isolate the bracket-cement interface, and to determine the influence of bracket base morphology and orthodontic bonding agent chosen on strength of adhesion. The bracket bases evaluated included 60, 80, and 100 single mesh bases, a double mesh base, and the Dynalock, and Mini Twin bases. The strength of interface provided by each of these bases with Concise, Transbond, Right On, and non-encapsulated Fuji Ortho LC cements, was measured in tension and recorded in Mega Pascals. The single-mesh bases performed well with either Concise or Right On (11*88-22*72 MPa) and, other than the 80-mesh bracket, relatively poorly with Transbond (2*18-5*15 MPa). With Fuji Ortho LC, the single mesh bases performed well (6*05-12*19 MPa). The double mesh base performed well with Right On (13*75 MPa), and reasonably well with Concise, Transbond, and Fuji Ortho LC (6*00-9*20 MPa). The Dynalock and Mini Twin Bases performed fairly well with all cements (8*87-17*16 MPa). It was concluded that the orthodontic bonding agent selected would appear to largely determine the bond strength achieved with a particular bracket base design. A definite trend was difficult to identify in this study, and it appeared that certain combinations of bracket base and bonding agent performed optimally. Particular base designs may allow improved adhesive penetration or improved penetration of curing light. Alternatively, the dimension and distribution of resin/cement tags prescribed by one base could promote a stress distribution that is better resisted by a particular adhesive.

Acrylic Resins↗
PubMed2000

Numerical investigation of fixed orthodontic brackets.

This paper presents the results of investigations into the mechanical behaviour of fixed orthodontic brackets. Special attention has been paid to the detailed modelling of the interface between the bracket base and an adhesive by which attachment is made to the tooth surface. Properties of this interface were taken as design parameters with the aim of investigating their influence on the stress field induced during bracket removal at the end of the treatment. Stress-strain analysis was performed using a finite element program developed in-house.

Dental Cements↗
PubMed1999

The relevance of attachment theory to a contemporary Jungian view of the internal world: internal working models, implicit memory and internal objects.

In this paper I examine the various meanings of the term 'internal object' and the differences between various theoretical models for the formation of internal objects. I suggest that the idea in attachment theory of 'internal working models' emphasizes the internal world as one consisting of unconscious internalized patterns of emotional relationships. The term 'internal object' lacks this clarity and the different meanings it carries within differing theoretical frameworks are a source of confusion. I describe the role implicit memory plays in the formation of 'internal working model's and suggest that these offer us an alternative explanation for unconscious fantasy and for object relationships to that of instinctual drives. This model is then brought to bear on contemporary Jungian concepts of the internal world, with a suggestion that, seen in this light, Jung's formulation of the concept of the complex has many features in common with the 'internal working model' of attachment theory.

Drive↗
PubMed1998

Combined stimulation of the glycine and polyamine sites of the NMDA receptor attenuates NMDA blockade-induced learning deficits of rats in a 14-unit T-maze.

The present study examined the effects of multi-site activation of the glycine and polyamine sites of the NMDA receptor on memory formation in rats learning a 14-unit T-maze task. The competitive NMDA receptor antagonist, (+/-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP, 9 mg/kg), was used to impair learning. The objectives were two-fold: (1) to investigate the effects of independent stimulation of the strychnine-insensitive glycine site or the polyamine site; (2) to investigate the effects of simultaneous activation of these two sites. Male, Fischer-344 rats were pretrained to a criterion of 13 out of 15 shock avoidances in a straight runway, and 24 h later were trained in a 14-unit T-maze that also required shock avoidance. Prior to maze training, rats received intraperitoneal (i.p.) injections of saline, saline plus CPP, CPP plus the glycine agonist, D-cycloserine (DCS, 30 or 40 mg/kg), CPP plus the polyamine agonist, spermine (SPM, 2.5 or 5 mg/kg), or CPP plus a combination of DCS (7.5 mg/kg) and SPM (0.625 mg/kg). Individual administration of either DCS or SPM attenuated the CPP-induced maze learning impairment in a dose-dependent manner. However, the combined treatment with both DCS and SPM completely reversed the learning deficit at doses five-fold less than either drug given alone. These findings provide additional evidence that the glycine and polyamine modulatory sites of the NMDA receptor are involved in memory formation. Furthermore, the potent synergistic effect resulting from combined activation of the glycine and polyamine sites would suggest a stronger interaction between these two sites than previously considered, and might provide new therapeutic approaches for enhancing glutamatergic function.

Animals↗
PubMed1998

An evaluation of the biomechanical response of the tooth and periodontium to orthodontic forces in adolescent and adult subjects.

This study was designed to quantify the magnitude of tooth mobility in adolescents and adults, and to investigate the differences in the biomechanical response of tooth and periodontium to orthodontic forces. The initial displacement of the maxillary central incisor was measured in 50 adolescent and fifty adult patients and the biomechanical properties of the periodontium were examined using the finite element method (FEM) and supporting experimental data. The magnitude of tooth mobility was significantly greater in the adolescent group than in the adult group. By integrating the differences in tooth mobility in both subject groups with analytical tooth displacements, the Young's modulus of the periodontal ligament (PDL) was demonstrated to be greater in the adults than in the adolescent subjects. The differing biomechanical properties of the PDL in adults were demonstrated to result in almost equivalent or somewhat increased stress levels in the PDL in adult subjects. It is suggested that this might produce a reduction in the biological response of the PDL and thus lead to a delay in tooth movement in adults.

Adolescent↗
PubMed1997

Self-esteem instability and its implications for HIV prevention among gay men.

This study, using a modified State Self-Esteem Scale (SSES), examined self-esteem instability and its association with risky sexual behavior among 455 gay and bisexual men. A self-administered questionnaire included the SSES and measures of intimacy, loneliness, social support, and ways of coping. Analysis of variance showed that the self-esteem of participants who recently engaged in unprotected anal intercourse with nonprimary partners was more unstable than the self-esteem of participants who did not engage in unprotected anal intercourse. Self-esteem instability was associated with higher avoidance coping, higher loneliness, and lower social support. Episodes of self-esteem injury might motivate some gay men to engage in risky sex. HIV prevention strategies with gay men should target the quality of their interpersonal relationships and community supports.

Adaptation, Psychological↗
PubMed1997

Internal objects--a theoretical analysis of Jungian and Kleinian models.

In this paper I discuss the ways in which experimental and objective research from cognitive science and developmental psychology can help analysts evaluate the theoretical models of mental objects which we use; I indicate the ways in which such evidence tends to support models of internal objects as mental representations or developmental capacities rather than as wish-fulfilling expressions of instinctual drives. This kind of empirical evidence is not just of academic interest but also has direct clinical relevance, particularly with borderline patients; such patients' sense of identity is totally dependent on the analyst's understanding of their internal world and for this to be misunderstood by the analyst can be catastrophic. An accurate theoretical model of mental objects can therefore help analysts to contain their patients more effectively.

Adult↗