Light surgical anaesthesia lasting 12-15 min was produced by metomidate at 50 mg/kg and by etomidate at 30 mg/kg after intraperitoneal injection. Full surgical anaesthesia lasting about 160 min was achieved after subcutaneous injection of a metomidate-fentanyl mixture (60 mg/kg: 0.06 mg/kg) and this proved superior to etomidate-fentanyl given subcutaneously or intraperitoneally. It was concluded that metomidate-fentanyl is superior to pentobarbitone and tribromoethanol as an injectable anaesthetic for mice.

Anesthesia, General↗

PubMed1981

Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience.

Ketamine alone or supplemented by diazepam or xylazine has been used and evaluated as an anaesthetic in a range of animals including snakes, tortoises, lizards, birds, ferrets, dogs, cats, pigs, sheep, goats, non-human primates, rabbits, guinea pigs, rats, mice and hamsters. Ketamine alone has severe limitations in most species, but in combination has proved valuable.

Anesthesia↗

PubMed1981

Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by clinical, virological, and immunopathological studies.

Multiple methods, pedigree analysis, clinical evaluation, and Epstein-Barr virus (EBV)-specific serology, EBV DNA hybridization of tissues to probe for viral genome, staining of touch imprints for EBV nuclear-associated antigen, establishment of spontaneous infected B-cell lines from peripheral blood or tissues, examination of peripheral blood smears, and hematopathology studies, were used to study seven patients with the X-linked lymphoproliferative syndrome and seven additional patients with life-threatening EBV-associated diseases. These studies demonstrated EBV in the tissues of all 14 patients and immunodeficient antibody responses to EBV were documented. This virus can produce various life-threatening lymphoproliferative diseases in a variety of immunodeficient patients.

Adolescent↗

PubMed1981

Duodenal duplication in the adult.

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Adult↗

PubMed1980

Sigmoidoscopic reduction of sigmoid volvulus.

Twenty-six patients were treated for a volvulus of the sigmoid colon between January, 1971, and June, 1979. Eight patients had an emergency resection and, although there was a high postoperative morbidity, there were no deaths in this group. An attempt to decompress the volvulus by means of a rigid sigmoidoscope was made in 18 patients. This was successful in 14 patients. Six of these patients suffered a recurrence, and perforation occurred in four patients, three of whom subsequently died. Because of the high risk of perforation, care should be taken with this procedure.

Aged↗

PubMed1980

Nesidioblastosis in children.

Three cases in which seizure disorder was first noticed were examined in the last seven years; low fasting glucose and high serum insulin levels then led to the diagnosis of severe hypoglycemia secondary to nesidioblastosis. Hypoglycemic episodes were uncontrolled by frequent oral feedings and intravenous administration of dextrose, glucagon, and diazoxide. Within three weeks after diagnosis, all three patients underwent subtotal pancreatectomy; all three survived and have been followed-up for two to seven years. Two remain euglycemic and have no evidence of CNS damage. The third has occasional fasting hypoglycemia that is treated with diazoxide; he continues to have a seizure disorder and is mentally retarded. Neonatal hypoglycemia secondary to hyperinsulinism requires prompt recognition and aggressive treatment to avoid irreversible CNS damage. Subtotal pancreatectomy safely and effectively restores the euglycemic state.

Adenoma, Islet Cell↗

PubMed1980

Evidence that autoimmunity in NZB mice is caused by a defect in immune specificity rather than a generalized defect in tolerance of self-antigens.

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Anemia, Hemolytic, Autoimmune↗

PubMed1980

Comprehensibility of the Dental Estimates Form FP17.

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Adult↗

PubMed1980

Community Health Care: assuring the quality of preventive care.

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Child Health Services↗

PubMed1979

The haves who feel more like have-nots.

The present and future problems of a so-called 'over-provided' region are defined and delved into by author, who asserts that even with existing human ingenuity the solutions will take time and painstaking planning.

Health Resources↗

PubMed1979