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Biomedical subjects

J Klozar

Publications and source records attributed to J Klozar.

13 recordsLinked to original sources
PubMed2005

HPV and other risk factors of oral cavity/oropharyngeal cancer in the Czech Republic.

OBJECTIVE: An association between high-risk human papillomavirus (HR HPV) infection and a risk of development of a subgroup of head and neck cancers has been proposed recently. The main risk factors of oral and oropharyngal cancer observed in our population are smoking and alcohol consumption. The incidence of oral/oropharyngeal tumours in the Czech Republic is relatively high and there are no data available about the prevalence of HPV DNA presence in these tumours. MATERIALS AND METHODS: Eighty patients with a primary oropharyngeal cancer were enrolled. The presence of HPV DNA has been evaluated by polymerase chain reaction in 68 cases from which the tumour tissue and demographical and clinical data were available. The typing of HPV was performed by nucleotide DNA sequencing. RESULTS: The HPV DNA was detected in 51.5% of samples tested. Among the HPV DNA positive tumours, 80% contained HPV16. In the analysed group there were 54 men and 14 women. The prevalence of HPV DNA was lower in oral (25%) than in oropharyngeal (57%) tumours, and higher in never smokers (100%) and never drinkers (68.8%). HPV DNA presence was not related to gender, age, number of lifetime sexual partners or practice of oral-genital sex, size of tumour or presence of regional metastases. CONCLUSIONS: The difference in the prevalence of HPV DNA positive tumours between cases of oral cavity and oropharyngeal carcinoma exposed and not exposed to tobacco or alcohol support the theory that HPV DNA positive tumours form an aetiologically distinct subgroup of head and neck tumours.

Adult↗
PubMed2001

Subjective functional results 1 year after surgery and postoperative radiation for oropharyngeal carcinoma.

This study was conducted to find out what factors most influenced functional results and patient satisfaction at 1 year after treatment in a homogeneous group of patients who had undergone surgery and postoperative radiotherapy for the treatment of oropharyngeal carcinoma. Further aims were to find out the relation between the overall and specific disease-related results and to compare the two questionnaires used. The study group consisted of 102 patients, 23 women and 79 men, with an age range of 41-77 years (mean 45.7 years). Two questionnaires were used for evaluation. The University of Washington head and neck quality of life questionnaire (UW-QOL) includes information about nine disease-specific domains and three questions on general quality of life. The second questionnaire used was the performance status scale for head and neck cancer patients (PSS), containing information about three disease-specific domains. Functional results were influenced by the size of tumor and by the surgical method used. Results worsened with increasing T stage. The best results were found after pharyngotomy without mandibulotomy, worse results, following temporary mandibulotomy with osteosynthesis, and the poorest results were found in the group of patients who had undergone composite resection. Neither age and sex of the patients nor the course of healing influenced the functional results. All results were significantly correlated to one another. The general parameters were also closely related to specific domains. An important correlation was found between the parameters in the two questionnaires.

Activities of Daily Living↗
PubMed2000

Prevalence of the sleep apnea syndrome in acromegaly population.

The prevalence of sleep apnea syndrome (SAS) in acromegaly is high. Consequences of SAS are serious and are associated with increased morbidity and mortality. The aim of this study was to assess the relative frequency and predictive factors for SAS in a group of patients with acromegaly (n=55). The presence of SAS was evaluated using the Polymesam device. Hormonal and clinical examination consisted of assessment of growth hormone, insulin-like growth factor I plasma levels, body mass index (BMI), neck circumference, age, sex, treatment modes of acromegaly and ear, nose and throat (ENT) examination. The relative frequency of SAS in our group of patients with acromegaly was 75%. Independent predictors of SAS were: increased activity of acromegaly, higher age and neck circumference. No association between SAS and BMI and ENT findings was observed. The role of gender was controversial.

Acromegaly↗
PubMed1997

Laryngeal papilloma--precancerous condition?

In a group of 179 patients treated for recurrent laryngeal papillomatosis 668 surgeries were performed in the years 1982-1995 in the Department of Otorhinolaryngology, Head and Neck Surgery in Prague. The group was divided into 77 patients with a juvenile form of papillomatosis and 102 patients with an adult form. The adult form was then divided into a multiple (65 patients) and solitary form (37 patients). Three patients with a juvenile form of papillomatosis were irradiated in advance. None of these patients developed a carcinoma. There were 3 cases (1.7%) of carcinoma in the whole group of patients with histologically verified papillomas during repeated previous surgeries. All 3 patients with malignancy had an adult form of papillomatosis, two with a multiple form and one with a solitary form. The intervals between the first treatment for papilloma and the diagnosis of carcinoma was 8, 3 and 2 years.The rates of malignant transformation of papillomas vary in the literature. We suppose, that because of the generally long interval between the diagnosis of papilloma and that of carcinoma, to make a final conclusion of a certain ratio is very difficult. We envisage that in our group of patients with papillomatosis new cases of carcinoma will occur in the future.

Adult↗
PubMed1993

[The sleep apnea syndrome. Basic diagnostic and therapeutic possibilities].

The sleep apnoea syndrome (SAS) involves impaired regular breathing during sleep. It causes poor quality sleep and thus subsequent somnolence in daytime, it leads to periodic oxygen desaturation and has serious cardiovascular consequences. The authors describe methods used for the diagnosis and quantification of the intensity of SAS which they used (all-night extended polysomnography, ambulatory equipment MESAM 4 and afternoon polysomnography) and they list also the main therapeutic procedures used in SAS.

Humans↗
PubMed1989

[Complications of CO2 laser surgery in the head and neck].

The authors analyzed data in the literature on complications of laser surgery in otolaryngology. Subsequently they analyse and describe in detail the complications they observed and which they encountered after 611 laser operations. None of the described complications caused permanent damage of the patient or the attending staff. When the recommended safety provisions are respected, the authors consider laser surgery a safe surgical method.

Adolescent↗
PubMed1989

[Treatment of benign laryngeal diseases using a CO2 laser].

CO2 laser surgery is becoming a part of larynx surgery. The authors inform about their experience in benign larynx tumours treatment. They present analysis of concrete therapeutic procedures in individual larynx affections. They conclude that laser surgery is an advantegous method for benign larynx tumours treatment.

Humans↗
PubMed1989

[Inverted papillomas].

Inverted papilloma is a relatively rare benign tumour of nasal mucosa and paranasal sinuses which approx. in 15% is connected with malignancy. The morphology, occurrence, etiology and biological behaviour of this tumour are dealt with. A group of 8 patients is presented. The significance of nasal polyps routine histologic investigation for early detection of these tumours is stressed. Various treatment possibilities are discussed and a therapeutic procedure based on radical surgery is suggested.

Adult↗