Biomedical subjects
Publications and source records attributed to J Kleeberg.
Goethe described at his first Italian journey in 1786, a disease of lombardic peasants which without doubt, unknown in Germany, was Pellagra. He suspected, based on his observations, that with high probability a wrong or deficient nutrition might be the cause of this illness.
The colour reaction of di-methyl-amido-benzaldehyde with metabolites in urine (especially with urobilinogen), discovered and published by Paul Ehrlich 80 years ago has lost nothing of its significance as a simple, practical, quick, qualitative test. It provides a diagnostic means in liver diseases, hemolytic processes, occlusion of the common bile duct, carcinoid and porphyrinopathies--of course, within the framework of the whole clinical picture. Despite the technical simplicity of the test, certain rules have to be adhered to. Ehrlich's aldehyde reagent has also won importance in chromatography. The modern test-strip technique permits an easy and rapid examination for urobilinogen (and bilirubin).
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Human uric acid acid renal stones are easily distinguished from other urinary calculi by their globular or spherical shape, their colour and their hardness. Investigations of uric acid crystals grown in the presence of a variety of pigments indicate that a disordered layer structure of the uric acid dihydrate is responsible for the colour of such crystals, caused by the inclusion of pigment molecules into the crystal lattice. This in turn may help to explain the other special properties of uric acid stones.
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