The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor with intrinsic tyrosine kinase activity. The IRR shares large homology with the insulin and the insulin-like growth factor-1 (IGF-I) receptor with regard to amino acid sequence and protein structure. So far, only a partial human sequence containing the complete 3' end has been reported, although the full-length human IRR cDNA had been used for transfection studies and functional analysis of the receptor. We have isolated a full-length human IRR cDNA and report on the 5' translated and untranslated region of the human IRR gene. The full length IRR sequence contains 4150 bases and shares a high degree of homology with the guinea pig IRR cDNA sequence and rat IRR sequences that had been reported earlier on by others. Sequencing of the IRR cDNA revealed that the human IRR cDNA contains 341 bases corresponding to the IRR 5' end in addition to the bases that had been reported on before. Also, this sequence contains the start codon of translation. The full length cDNA for the human IRR can now be used for functional expression studies and to elucidate the nature of the ligand for this receptor type.

Cloning, Molecular↗

PubMedDate not supplied

[Size of wound area and frequency of alveolitis after tooth extraction].

Electron spin resonance was used to measure out 160 tooth root surfaces. These data represent a measure for wound area sizes after tooth extractions. A comparison of these values with clinical data results in a correlation between the size of wound area and the frequency of inflammatory healing disorders after tooth extractions.

Dry Socket↗

PubMedDate not supplied

[Relation of alveolitis after tooth extraction and extraction trauma].

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Adult↗

PubMedDate not supplied

[Prognosis in sarcoma of the jaw].

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Humans↗