Biomedical subjects
J Kirk
Publications and source records attributed to J Kirk.
Cumulative radiation effect. I. Fractionated treatment regimes.
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Superficial radiotherapy in acne vulgaris.
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Mitotic autoregulation of populations of normal and malignant cells.
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Cybernetics of the red-blood-cell and bone-marrow stem-cell system.
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Stress cycle analysis in the biocybernetic study of blood cell populations.
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The pericarditis of rheumatoid arthritis.
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A study of the interdependence of red cell and bone marrow stem cell populations.
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A mathematical analysis of red blood cell and bone marrow stem cell control mechamisms.
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Observations on the histology of the choledocho-duodenal junction and papilla duodeni, with particular reference to the ampulla of Vater and sphincter of Oddi.
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A Case of Megalo-duodenum with various Vascular Abnormalities.
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An examination of the relationship between dyslexia and offending in young people and the implications for the training system.
A screening study was undertaken which involved 50 young offenders, serving sentences of various lengths, all from the largest young offenders' institution in Scotland. All 50 were screened for dyslexia and a number received a more detailed follow-up assessment. The results of the screening showed that 25 of the young offenders (50%) were dyslexic to some degree. This finding has implications for professionals, particularly in respect of follow-up assessment and support, and for politicians in relation to issues such as school experience, prison education and staff training. These issues are discussed here in relation to the background and results of the study.
Voice changes: an initial manifestation of colonic perforation.
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Peptide contamination from cellulose dialysis membrane.
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Phenotypic characterization of immature lymphoid cells in human umbilical cord blood.
The antigenic phenotype of neonatal lymphoid cells isolated from umbilical cord blood was investigated using monoclonal antibodies and flow cytometry. Although the majority of cells expressed mature T or B cell differentiation antigens, small subpopulations of phenotypically immature lymphocytes were detected. A small proportion (mean 2.8%) of cells expressed the common acute lymphoblastic leukaemia antigen (CD-10), a significantly higher figure than that detected on adult peripheral blood lymphocytes. The cortical thymocyte antigen (CD-1) was detected on a very small subset of cord lymphoid cells, but was also present on adult lymphocytes at approximately the same frequency. The nuclear enzyme terminal deoxynucleotidyl transferase (TdT), a marker of early lymphoid differentiation, was detected by immunofluorescence on 0.031% of mononuclear cells in cytocentrifuge preparations, representing an approximate 10-fold increase in frequency over expression in childhood or adult blood. These circulating TdT+ cells were shown in double labelling experiments to predominantly express markers of B cell differentiation (CD-24, CD-10, MHC Class 2), although occasional cells co-expressing the T lineage marker CD-2 were also seen. These findings are consistent with the circulation of B cell precursors in neonatal blood. The nature of the CD-1+ cells is unclear, although the absence of CD-1+ TdT+ double labelled cells mitigates against the possible presence of immature thymus-processed lymphocytes in these samples.