Biomedical subjects

J Kesselring

Publications and source records attributed to J Kesselring.

57 records · Page 4Linked to original sources

PubMed1983

Lethality of pentazocine and tripelennamine combinations in mice housed individually and in groups.

Lethality of 80 mg/kg pentazocine alone; 40 mg/kg tripelennamine alone; 20 mg/kg tripelennamine in combination with 40, 60, and 80 mg/kg pentazocine; and 40 mg/kg tripelennamine in combination with 10, 20, and 40 mg/kg pentazocine was determined in mice housed individually and in groups. Results indicate that the lethality of pentazocine and tripelennamine combinations in mice is (1) dose-dependent, (2) potentiated relative to either drug alone, and (3) greater in group-housed than in individually-housed animals.

Animals↗

PubMedDate not supplied

Respiratory function in chronic hemiplegia.

Dynamic spirometry was examined in 23 non-smoking hemiplegic patients after the acute phase. The decrease of slow inspiratory forced capacity is related to motor impairment and does not vary with time. The forced inspiratory and expiratory vital capacities are similar to the slow inspiratory vital capacity in the first 6 months of the disease, but significantly decrease later independent of the motor impairment. The peak expiratory flow is highly variable but is clearly decreased, and is related to motor impairment. These results point to a restrictive respiratory syndrome due to mechanical limitation of thorax excursions caused by weakness, hypotonicity, and incoordination of the trunk musculature. The importance of long-term physiotherapy of the trunk is emphasized.

Adult↗

PubMedDate not supplied

Severe traumatic brain injury--epidemiology and outcome after 3 years.

In 1987 80 patients living in the region of St Gallen, Switzerland, suffered from head injury with neuroradiologically visible intracranial lesions (annual incidence 20/100,000). One-quarter died during the first month after injury, and six others during the following 3 years. All except three of the 45 survivors interviewed and examined after 3 years had symptoms and functional impairment related to injury: neuropsychological (78%), behavioural (58%), neurological (53%), and related to bone or soft tissue trauma (36%). Half of the patients suffered from headache. Although these impairments caused little disability--only 5% of the patients had a Glasgow Outcome Score of 2 or 3--handicap in social life was reported in half of them and only 13 of 29 working before the accident were able to resume their former work. The consequences for long-term management of these patients are discussed.

Adolescent↗