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Biomedical subjects

J Kemp

Publications and source records attributed to J Kemp.

At least 73 records · Page 4Linked to original sources
PubMed1985

Excretion of doxepin and N-desmethyldoxepin in human milk.

Doxepin and N-desmethyldoxepin concentrations in plasma and breast milk from a lactating mother and in plasma from her infant were measured during an 8 week period using high performance liquid chromatography. Plasma concentrations ranged from 35-68 microgram l-1 for doxepin and 65-131 microgram l-1 for N-desmethyldoxepin. Mean pre-feed milk/plasma ratios were 1.08 and 1.02 for doxepin and N-desmethyldoxepin respectively and increased to 1.66 and 1.53 at the post-feed samples. Only N-desmethyldoxepin (15 microgram l-1) was detectable in the infant's plasma sampled after 43 days of maternal therapy.

Adult↗
PubMed1984

Nursing at night.

This paper presents a review of the literature on nightwork as it pertains to nursing in general hospitals. It is based upon some 250 articles, reports and books. Research into the effects of nightwork on females, who predominate in nursing, is very limited. Objective descriptions of nursing at night are also rare. The literature review develops three main themes: the problems faced by night and shiftworkers, the maintenance of a 24-hour nursing service in hospitals and activity on the hospital ward at night.

Female↗
PubMed1984

The use of the trimethyltin model of CNS neurotoxicity to study biochemical indices of neuropathological change in the rat.

Trimethyltin (TMT)-induced CNS neurotoxicity in the rat was used to study biochemical indices of neuropathological change. The parameters measured were DNA and the lysosomal enzymes beta-glucuronidase and beta-galactosidase. Three brain regions were investigated, hippocampus, medulla and cerebellum. Rats received 4 mg/kg TMT weekly for a maximum of 5 weeks. The largest changes were found in the hippocampus, with smaller changes in medulla and no changes in the cerebellum. In the hippocampus the beta-glucuronidase activity was increased after three weeks to a maximum of 264% of the mean control value, while the beta-galactosidase activity was reduced to 87% of the control value. The lysosomal enzyme changes were attributed to processes of astrocytic and microglial hypertrophy and neuronal cell loss. The neuronal cell loss was further substantiated by the gradual reduction in the level of DNA in the hippocampus. It was concluded that the TMT model of CNS neurotoxicity in the rat hippocampus was a useful tool for studying biochemical indices of neuropathological change.

Animals↗
PubMed1981

Ageing.

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Adaptation, Psychological↗
PubMed1980

Suppressor cells in vitro: differential effects of indomethacin and related compounds.

In vitro immune response systems known to involve suppressor cell regulation were examined for effects produced by the drug indomethacin and other compounds known to inhibit the cyclooxygenase pathway of arachidonic acid metabolism. In all cases tested where suppressor T cell activity is known to be the dominant inhibitory mechanism, suppression was not blocked by drug addition and was sometimes more pronounced. In the cases tested where suppression could be attributed to a non-T cell, most likely a macrophage-like cell (M0), suppression could be abolished by drug treatment. Indomethacin and related compounds may be useful analytical tools for separation of T cell vs. non-T cell mediated suppression.

Animals↗
PubMed1979

Immunoregulatory circuits among T cell sets: effect of mode of immunization on determining which Lyl T cell sets will be activated.

Lyl T cells are able to induce B cells to make antibody and also to induce a resting Lyl23 T cell set to exert potent feedback suppression. Which of these two pathways Lyl T cells take can be influenced by the mode of immunization. In particular, in vitro immunized Lyl T cells are more likely to induce suppression than are Lyl T cells immunized in vivo even when both populations deliver the same amount of help to purified B cells. The feedback suppression induced by the Lyl T cells immunized in vitro can be distinguished from suppression mediated by Ly2+ T cells; in the former case suppression is preceded by a precocious antibody response, whereas suppression mediated by Ly2+ T cells is apparent throughout the entire period of observation.

Animals↗