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J Kaufmann

Publications and source records attributed to J Kaufmann.

At least 91 records · Page 5Linked to original sources
PubMed1979

[Demonstrations].

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Adrenal Cortex Hormones↗
PubMed1979

[Basaliomas after vaccination and infusion in basal cell nevus syndrome].

In a 31-year-old patient with a basal cell nevus syndrome two basal cell epitheliomas occurred through exogenous factors. The tumors appeared within 18 years after BCG vaccination and 3 years after an intravenous drip respectively. In basal cell nevus syndrome this course of development of basal cell carcinomas is seldom described.

Adult↗
PubMed1978

[Comparison of the epidermodysplasia verruciformis Lewandowsky-Lutz with the other Papova virus acanthomas by light and electron microscopy (author's transl)].

Based on histology and electron microscopy, a series of Papova virus acanthomas consisting of 300 common warts and Condylomata acuminata as well as primary efflorescences of 7 typical and 7 questionable cases of Epidermodysplasia verruciformis have been classified. Four cytological types expressing different cytopathogenic viral actions were established. Typ 4 ("basophilic foamy giant keratinocytes") seems to be specific for Epidermodysplasia verruciformis which thus can be differentiated histologically against ordinary warts (type 1-3).

Condylomata Acuminata↗
PubMed1978

SOluble and insoluble immune complex-platelet interactions in rheumatoid inflammation.

The interactions of soluble and insoluble immunoglobulin G (IgG) complexes with macromolecular rheumatoid factor (RF) and platelets were examined in an in vitro system permitting observation of platelet activities which may contribute to rheumatoid inflammation. Studies of the aggregation phenomenon by the nephalometric technique and by selective sedimentation of 51Cr-labelled platelets revealed no aggregation by platelets exposed to heat aggregated IgG (HAIgG) complexes or their RF precipitates in a plasma test system. Release of serotonin was demonstrated by the increasing radioactivity of platelet supernates to 45 min by 14C-serotonin labelled platelets exposed to insoluble IgG heat aggregates. Significantly less release was shown with saline, native IgG, and soluble IgG complexes. When RF was added to soluble HAIgG complexes, the resulting precipitate caused significantly higher release than controls. No concomitant release of the lysosomal enzyme beta-glucuronidase was detected. Thus, although soluble complexes do not cause significant release of biologically active amines, conversion of soluble complexes to insoluble immune precipitates by RF is associated with this activity which is independent of platelet aggregation and/or lyosomal enzyme release in our test system. Release of biologically active amines from platelets exposed to insoluble complexes may be important in the initiation and propagation of inflammation in rheumatoid arthritis.

Antigen-Antibody Complex↗
PubMed1977

[Therapy of androgenization symptoms: double blind study of an antiandrogen preparation (SH B 209 AB) against neogynon (author's transl)].

The antiandrogen-containing preparation SH B 209 AB was tested in comparison with an ovulation inhibitor with no antiandrogenic effect (Neogynon) in a randomized, double blind study conducted to determine the effects of both on androgenization symptoms. 88 patients took part in the study. In the majority of cases the duration of the treatment period was more than 6 months. It was shown that the therapy with the combination preparation containing cyproterone acetate was distinctly more successful in cases of acne and seborrhoea: not only acne in its various locations but also all forms of seborrhoea were more favourably influenced by the trial preparation. This difference was statistically significant (p less than 0.05). It was not possible to establish a significant difference between the two preparations in the case of hirsutism in its various locations from the limited number of cases observed. There were also no differences detected in hepatic tolerance. During treatment with both preparations all values measured were within the normal range.

Acne Vulgaris↗
PubMed1976

Immunoglobulin G complex interactions with rheumatoid factor and neutrophils: 51CrCl3 labelling and 14CO2 hexose monophosphate shunt studies.

The interactions of soluble and insoluble IgG complexes with macromolecular rheumatoid factor (RF) and neutrophils have been examined in an in vitro system allowing the separate assay of the biologic activities of these elements in the rheumatoid inflammatory process. Studies utilizing soluble and insoluble 51CrCl3 labelled human IgG complexes have demonstrated uptake of only the insoluble complexes by human neutrophils. A burst of hexose monophosphate shunt activity, as evidenced by increased oxidation of glucose-l-14C to 14CO2, has been shown to occur only when neutrophils are exposed to these insoluble complexes. High titer RF sera added to the insoluble complexes prior to their incubation with neutrophils did not affect either the uptake of the complexes or the magnitude of hexose monophosphate shunt activity. Native IgG and soluble IgG complexes were not taken up by the neutrophils and did not stimulate hexose monophosphate shunt activity in the presence or absence of rheumatoid sera. The addition of high titer RF sera to soluble IgG complexes produced precipitation of RF-IgG complexes which were capable of stimulating hexose monophosphate shunt activity in normal neutrophils. RF thus has been shown to change functionally inactive soluble complexes into functionally active insoluble complexes capable of stimulating normal neutrophils. Neutrophil stimulation by insoluble complexes may be important in the continuing inflammatory process occurring in the joints of patients with rheumatoid arthritis.

Arthritis, Rheumatoid↗
PubMed1976

Neutrophil and rheumatoid factor-Immunoglobulin G insoluble complex interactions: phagocytosis and sequelae.

Studies utilizing 51CrCl3 labelled human immunoglobulin G have demonstrated a quantitative, time-related increase in the uptake of insoluble rheumatoid factor-immunoglobulin G complexes by human neutrophils. A burst of hexose monophosphate shunt activity occurs when these complexes are phagocytized by neutrophils as evidenced by the increased oxidation of glucose-l-14C to 14CO2. Metabolic and electron micrographic studies suggest that a heat stable serum factor is needed for maximum complex uptake and shunt activity. Phagocytosis of complexes did not affect the adherence of neutrophils to nylon fiber columns, but did not produce selective release of lysosomal enzymes. This study has delineated in an in vitro system, functional and metabolic sequelae of neutrophil phagocytosis of insoluble rheumatoid factor-immunoglobulin G complexes, which may be important components of the inflammation occurring in the joints of patients with rheumatoid arthritis.

Glucuronidase↗
PubMed1975

In vivo uptake and metabolism of 3-h-5alpha-androstane-3alpha,17beta-diol and of 3-h-5alpha-androstane-3beta,17beta-diol by human prostatic hypertrophy.

Tritiated 5alpha-androstane-3alpha,17beta-diol (3alpha-diol) and 5alpha-androstane-3beta,17beta-diol (3beta-diol) respectively were administered to patients with benign prostatic hypertrophy (bph) undergoing prostatectomy. In prostate and skeletal muscle homogenates and in plasma the total radioactivity content as well as the formation of metabolites were measured. Histological examination of each ectomized prostate was performed to evaluate the cellular composition of the tissue. After 3alpha-diol injection, a higher uptake of radioactivity in the prostate was obtained than after 3beta-diol. Within 30 min the 3alpha-isomer was very efficiently converted to 5alpha-DHT, while most of the 3beta-isomer remained unchanged. There was, however, also after administration of the 3beta-diol a substantial biconversion to 5alpha-DHT as has been confirmed by recrystallization to constant specific radioactivity. Only after 3beta-diol epiandrosterone was detected in small but significant amounts. 3alpha-diol administration resulted in distinct concentrations of 3beta-diol, whereas the conversion of 3beta-diol to the 3alpha-isomer was insignificant. When comparing the histological composition of the prostatic tissue with the accumulation of radioactivity and the formation of metabolites only a weak correlation between glandular structure and radioactivity uptake after 3alpha-diol administration could be revealed.

Aged↗