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Biomedical subjects

J Karchmar

Publications and source records attributed to J Karchmar.

6 recordsLinked to original sources
PubMed1986

Treatment of cervical intraepithelial neoplasia with electrocautery: a report of 776 cases.

From 1973 to 1984, 776 patients with cervical intraepithelial neoplasia were treated with outpatient electrocautery (hot cautery) without anesthesia. Of these, 726 (94%) were available for follow-up in 3 to 6 months. An initial cure rate with one treatment of 89% to 90% was achieved. Cure rates were similar for all degrees of dysplasia, including carcinoma in situ. There were no complications. All patients with failure of the initial treatment who returned for further outpatient management were eventually cured with use of electrocautery. Long-term follow-up rates ranged from 75% at 1 year to 46% at 5 years. There were few late recurrences, most of which were treated again (successfully) with electrocautery. Electrocautery produces cure rates similar to those for other forms of conservative management and may be the most cost-effective method of management of cervical intraepithelial neoplasia.

Ambulatory Surgical Procedures↗
PubMed1978

Intrapartum fetal asphyxia: a preliminary report in regard to long-term morbidity.

This is a preliminary report of a prospective follow-up study of 42 infants who had episodes of intrapartum fetal asphyxia at delivery identified by an acid-base assessment and a control group of 69 babies who had no evidence of intrapartum fetal asphyxia. The newborn infants were mature at delivery. There were no major neurologic disabilities in the asphyxia group. The pattern of physical growth and the mental and physical development indices of the babies of the asphyxia group were similar to those of the control group babies at 12 months of age. Results have not as yet indicated that the mature fetus with at least a terminal episode of asphyxia will exhibit evidence of handicap due to central nervous system injury.

Asphyxia Neonatorum↗
PubMed1978

Intrauterine growth retardation: a preliminary report of long-term morbidity.

This is a preliminary report of a prospective follow-up study of 88 intrauterine growth-retarded (IUGR) babies and a control group of 97 babies with weights appropriate for gestational age. The characteristic clinical features of IUGR pregnancies were observed in the obstetric patients of the IUGR group. The babies of the IUGR group have a phase of accelerated growth during the 3 months following delivery although they continue to be smaller than the babies of the control group at 12 months of age. No major neurologic abnormalities have been noted in the IUGR babies although behavioral differences were observed during the neonatal period and at 12 months of age. There were lower mental and physical development indices at 12 months of age which were due to the IUGR babies of lowest birth weight and those with a low maternal urinary estrogen index.

Asphyxia Neonatorum↗
PubMed1977

Intrapartum fetal asphyxia: clinical characteristics, diagnosis, and significance in relation to pattern of development.

The clinical and fetal heart rates and acid-base characteristics and their sequelae have been reviewed in 587 patients. The relevant clinical factors in the asphyxia group were the preterm fetus, the intrauterine growth retarded fetus, maternal toxemia, and midforceps delivery. The duration of the developing metabolic acidosis in the asphyxia group ranged from terminal to the last two hours of labor. Marked patterns of total decelerations and moderate and marked patterns of late decelerations are of predictive value in the diagnosis of intrapartum fetal asphyxia with a trend to an increased incidence in the longer duration categories, between four and two hours prior to delivery, and a significant increase in all categories during the last two hours of labor. The significance of intrapartum fetal asphyxia to the newborn infant is evident from the low Apgar scores, increased incidence of moderate and severe respiratory distress syndrome, and central nervous system complications in the asphixia group in relation to the normal group.

Acid-Base Equilibrium↗