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Biomedical subjects

J Kanto

Publications and source records attributed to J Kanto.

At least 235 records · Page 13Linked to original sources
PubMed1975

Morphine concentrations in plasma after intramuscular administration.

Plasma morphine concentrations were measured by a radioimmunoassay technique following the intramuscular administration of morphine 0.2 mg/kg body weight as a preoperative medication. The highest plasma concentrations were obtained about one hour after the administration of the drug and there was a sevenfold variation in these concentrations between individuals. For 24 hr following a single intramuscular injection, there was measurable quantities of morphine or its metabolites in the plasma. In healthy patients who were undergoing a therapeutic abortion, there was no correlation between pain relief and the plasma concentration of morphine.

Abortion, Therapeutic↗
PubMed1975

Plasma concentrations of diazepam and its metabolites after peroral, intramuscular, and rectal administration. Correlation between plasma concentration and sedatory effect of diazepam.

Plasma levels of diazepam, N-demethyldiazepam and free oxazepam were measured gaschromatographically in ten healthy volunteers after 5 mg of diazepam perorally, intramuscularly and rectally (with three different kinds of suppositories). The best absorption of diazepam was found after peroral administration. After an intramuscular injection a delayed absorption with low plasma concentrations of diazepam was found. The basal component of a diazepam suppository seems to have a great effect on the rectal absorption of diazepam. Two of the three different kinds of diazepam suppositories caused higher plasma diazepam concentrations than the intramuscular injection of the drug. There were no great differences in the amount of the metabolites of diazepam after different kinds of administration. The subjective sedatory effect of diazepam lasted approximately as long as the fast distribution of diazepam from plasma took place. A very highly significant correlation between plasma concentration and subjective sedatory effect of diazepam after a single dose was found.

Administration, Oral↗