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Biomedical subjects

J Kanka

Publications and source records attributed to J Kanka.

At least 73 records · Page 4Linked to original sources
PubMed1984

Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. I. Epidemiological characteristics.

To determine the risk associated with previous herpes simplex type-2 (HSV-2) infection and possibly other virus infections, a prospective study of cervical neoplasia in more than 10,000 women was performed in the 1975-1983 period. The subjects were selected at random from an alphabetical listing of eligible women living in one district of Prague. At enrollment colposcopy and cervical cytology were performed, a blood sample was taken and data regarding education, socio-economic status, personal habits and sexual and reproduction-associated attributes were obtained from each woman. A total of 10,683 women were enrolled; a complete set of data was obtained in 10,389 women. Women with normal or non-significant findings were invited for further colposcopical and cytological investigations after 2 years and 4 years, the other women were followed at 3- to 6-monthly intervals. In women with highly significant findings, histological investigation was performed. The total of 150 cases of moderate to severe dysplasia (i.e. cervical intraepithelial neoplasia, grade II, CIN II), 83 cases of carcinoma in situ (CIN III) and 21 cases of invasive carcinoma (INCA) were detected. More than 60% of the patients were ill at enrollment, the other cases developed in subjects with originally slightly suspicious (27 CIN II, 17 CIN III, 3 INCA) or negative findings (30 CIN II, 12 CIN III, 3 INCA). Analysis of the data indicated significantly positive correlation of one or more of these clinical conditions with a number of sexual and reproduction-related attributes of which early age at first intercourse was most consistent. Among the other attributes, the smoking habit was associated with the highest risk of developing the disease. A negative correlation of cervical neoplasia with several attributes was demonstrated; of these diathermoelectrocoagulation of the ectopic epithelium and transformation zone of cervix was the most important single protective factor. On the basis of these findings, control subjects were selected for serological studies.

Adult↗
PubMed1984

Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. II. Herpes simplex type-2 antibody presence in sera taken at enrollment.

Sera obtained at enrollment in the study from patients suffering from moderate to sever dysplasia (cervical intraepithelial neoplasia grade II), carcinoma in situ (cervical intraepithelial neoplasia grade III) and invasive carcinoma, or developing any of these conditions in the course of the prospective study, and from control subjects, were examined for herpes simplex type-2 (HSV-2) antibody presence. The controls were matched with the patients by age, age at first intercourse, number of sexual partners, smoking habits and history of diathermoelectrocoagulation of the ectopic epithelium and transformation zone of cervix. Only those subjects were selected as controls who remained free of pathological colposcopical and cytological findings throughout the observation period, i.e. for at least 4 years after their serum sample was obtained. The microneutralization test (MNT) and type-2-specific solid-phase radioimmunoassay (SPRIA) were used as serological tests. No difference in the prevalence of HSV-2 antibody between the patients and controls was revealed by either test. Various combinations of the results from the two tests also failed to show any difference between patients and controls. Moreover, no significant differences were observed in the prevalence of HSV-2 antibody between patients suffering from the various pathological conditions and those diagnosed at enrollment and later in the course of the study. These results do not provide any support for the hypothesis of the involvement of HSV-2 in cervical neoplasia.

Animals↗
PubMed1983

Effects of exercise on serum cortisol and thyroid hormones.

Serum levels of hydrocortisone, T4, T3 and rT3 were estimated before and after exercise. In group A, untrained young subjects had to cope with a submaximal, fractionated load on a bicycle ergometer. T3 increased, rT3 and cortisol decreased, T4 remained unchanged. Sportsmen in group B accomplished a 10 or 15 km run as a part of their regular training. A rise of cortisol and rT3 was observed, T3 remained unchanged and T4 decreased. In better trained sportsmen the initial level of serum T3 exceeded the upper border of normal values (3.3 nmol/l) and the terminal values of cortisol reached a higher value than in the less trained subjects. It is suggested that the mobilization of fuel from energy stores and the oxidative processes are better regulated in trained sportsmen than in untrained subjects. A sign of the best adjustment to a long run was accompanied by an initial serum T3 above the normal borderline and by a great increase of cortisol after the run.

Adult↗
PubMed1979

Measurement of tissue impedance in the prevention of carcinoma of the uterine cervix.

The authors tested the possibilities of an apparatus for the assessment of tissue impedance -- DIACA LDN 200 -- in routine prevention of carcinoma of the uterine cervix. They found that by assessment of the impedance it is possible to differentiate normal squamous epithelium from calumnar epithelium and pathological epithelium. The latter two cannot be differentiated reliably by the apparatus. Therefore DIACA is not suited as a single method for the detection of precancerous conditions but in combination with colposcopy it may provide reliable services. In the discussion the authors reflect where to include most aptly the above method in the complex of prevention of carcinoma of the uterine cervix. Recently a new apparatus, DIACA LDN 200, was introduced on the market which can be used to measure tissue impedance. This apparatus proved useful in the detection of precancerous conditions and early carcinoma of the intestine (1, 2, 3). The basic idea links up with the work of Zwinger and Vrana (5, 6, 7) which some time ago aroused considerable attention but never was introduced in practice on a major scale. It is therefore of interest to test whether measurement of tissue impedance by means of this apparatus can be used in gynaecology and whether we may count on this method as a screening procedure in the prevention of carcinoma of the cervix.

Colposcopy↗
PubMed1977

Immunological response of patients with tumors of the urogenital tract: a follow-up of cell-mediated antitumor immunity by the LAI test.

Antigen-induced inhibition of leukocyte adherence is a suitable method providing information on immunological response of the tumor bearers. Leukocytes from patients' blood were tested by an in vitro method to detect cell-mediated antitumor immunity. Positive reactions of leukocytes to the specific antigen were found in carcinoma of the uterine cervix, vulva and ovary in 13 patients. The modified LAI test evaluated on the basis of free cells in Eagle's medium using the specific antigen is a simplified reversed method which, however, keeps the specificity.

Female↗