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Biomedical subjects

J Kanitakis

Publications and source records attributed to J Kanitakis.

At least 217 records · Page 12Linked to original sources
PubMed1984

HLA antigens in pityriasis versicolor.

The distribution of 30 HLA antigens was studied in 48 patients with Pityriasis Versicolor and 134 controls. No significant deviations were found in the patient group after correction for the number of antigens tested.

Cytotoxicity, Immunologic↗
PubMed1984

Immunohistologic study of cellular populations of histiocytofibromas ("dermatofibromas").

Histiocytofibromas (HF) are benign tumours of the skin, the cellular composition of which is not yet known with certainty. The immunohistologic characteristics of 5 lesions were studied by using monoclonal antibodies and an indirect immunofluorescence method. All tumours were found to contain HLA-DR(+) cells, and, to a minor degree, OKM1(+) cells. OKT6(+) cells were present in the epidermis overlying the tumours; however in the HF themselves, no OKT6(+) cells were found. The presence of HLA-DR(+) and OKM1(+) cells demonstrates that HF contain cells bearing antigenic characteristics of histiocytes but not of Langerhans' cells, and we feel that the term "histiocytofibroma" is a more accurate designation for these lesions than "dermatofibroma".

Antibodies, Monoclonal↗
PubMed1984

Unusual vascular tumour of the scalp in association with lymphoid aggregates: a variant of angiolymphoid hyperplasia?

A 51-year-old mason presented with a large tumour on his scalp which had developed over the previous 2 years. Histological examination showed the presence of large vessels with muscular coats some of which appeared to be venules and others arterioles. They had markedly swollen cuboidal endothelial cells and a surrounding mononuclear cell infiltrate which in areas formed lymphoid follicles some of which had germinal centers. There was no evidence of tissue or blood eosinophilia. The unusual clinical and histological features of this case are emphasized and the nosology of this rare condition is discussed.

Angiolymphoid Hyperplasia with Eosinophilia↗
PubMed1984

[Tubular apocrine adenoma: apropos of a case].

Tubular apocrine adenoma is a rare, benign apocrine tumour of the skin, histologically distinct from other epithelial proliferations, showing apocrine differentiation. A new case of this uncommon lesion is reported herein and a review of the literature concerning this tumour is made.

Adenoma↗
PubMed1984

[Calcified Malherbe epithelioma of an unusual histological type].

A case of calcifying epithelioma (of Malherbe) is reported, which seems to be developing on an epidermal cyst: microscopic examination shows a sudden transformation of the wall of the epidermal cyst into a calcifying epithelioma. This histological feature is very rare: only 2 similar cases have been reported in the literature until now.

Adult↗
PubMed1983

Anti-D47: a monoclonal antibody reacting with the secretory cells of human eccrine sweat glands.

Anti-D47 is a monoclonal antibody reacting with a surface antigen of human cortical thymocytes (different from the T6 antigen). It was prepared by immunization of mice with human thymocytes. The known cross-reactivity of monoclonal antibodies prepared against thymic cells with skin components prompted us to test anti-D47 on human skin as well as animal tissues. No labelling was observed on animal tissues. On human skin, anti-D47 was found to react with the secretory portion of eccrine sweat glands (ESG), i.e. with a cytoplasmic antigen of the secretory cells lining the deep portion of ESG glomeruli. No labelling was observed on apocrine sweat glands or on the excretory portion of ESG. Anti-D47 was also tested on histologically proven extramammary (vulvar) Paget's disease and basal cell epitheliomas: no staining of the neoplastic cells was observed. Anti-D47 appears to be an immunological marker of the secretory cells of human ESG and a new tool for the investigation of human sweat gland pathology.

Animals↗
PubMed1983

[Clear cell acanthoma. Ultrastructural and immunohistological study].

We report a new case of a clear-cell acanthoma with an unusual location (para-anal), which was studied by electronmicroscopic and immuno-histological methods, using monoclonal antibodies. The results of this study showed that: a) the inflammatory cellular infiltrate comprised a small number of T-suppressor/cytotoxic lymphocytes and a small number of Langerhans cells, b) Langerhans cells were present in the affected epidermis in reduced numbers (2.2 p. 100) when compared to normal epidermis (4-6 p. 100), c) there was a disorder of both keratinization and epidermal differentiation as was shown by the abnormal reactivity of the tumor to monoclonal antibodies KL1 and BL7, d) human papilloma viruses do not seem to be involved in the genesis of the tumour, e) tumoral cells did not show (secretory) eccrine differentiation, f) the pemphigus antigen was present in the intercellular space of the affected epidermis.

Anal Canal↗
PubMedDate not supplied

[Bullous paraneoplastic acrokeratosis].

BACKGROUND: Bullous lesions of acral distribution are an uncommon finding in Bazex's syndrome (acrokeratosis paraneoplastica). We report here one of these rare cases. PATIENTS AND METHODS: A 65 year-old-man, an alcoholic and a smoker, presented with characteristic lesions of Bazex's acrokeratosis paraneoplastica associated with a right cervical lymph node mass. An epidermoid carcinoma of sinus piriformis was then discovered. The acrokeratosis lesions worsened and spread to the knees, elbows, trunk and genitalia, with an erosive aspect, pain in the extremities, and tender, hemorrhagic bullous lesions on the toes and sides of the feet. Histological examination of a biopsy sample showed a subepidermal blister with numerous eosinophilic leucocytes. Direct immuno-fluorescence showed C3 deposits on dermal capillaries and IgA and IgM on colloid bodies in the papillary dermis. Blood eosinophilia and high levels of IgE were noted. Indirect immunofluorescence was negative for anti-epidermal and anti-basement membrane antibodies. Radiation and chemotherapy for the neoplasia resulted in healing of the bullous lesions and almost complete disappearance of keratotic squamous lesions with residual hyperpigmentation. DISCUSSION: Although bullous lesions are rare in Bazex's syndrome (acrokeratosis paraneoplastica), they were noted as early as 1968 by Degos et al. These acral bullae mimic autoimmune bullous disease. An immunological reaction is thought to occur with antigens of the dermal-epidermal junction and eosinophils appear to be involved.

Aged↗
PubMedDate not supplied

Vulvar cicatricial pemphigoid of childhood.

We report a 9-year-old girl with a vulvar autoimmune bullous dermatosis. A diagnosis of localized bullous pemphigoid or cicatricial pemphigoid was made on the basis of immunohistologic data. Since the lesions were unresponsive to topical corticosteroids but healed completely on dapsone at a dosage of 1.5 mg/kg/day, we favor the diagnosis of vulvar cicatricial pemphigoid. Only two such cases have been reported thus far. The diagnostic criteria and therapeutic modalities are discussed.

Child↗