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Biomedical subjects

J Kangas

Publications and source records attributed to J Kangas.

At least 37 records · Page 2Linked to original sources
PubMed1995

The effect of fiber length on the dissolution by macrophages of rockwool and glasswool fibers.

The effect of fiber length on the dissolution of experimental rockwool and commercial glasswood fibers in rat alveolar macrophage (AM) culture and in mere culture medium was studied. The ultrastructure of macrophages after their exposure to fibers and the suitability of macrophage-type cell line P388D1 culture in dissolution studies were also explored. The fiber samples included short (ground) and long (untreated) rockwool and glasswool fibers. The fibers were incubated in rat AM cultures, in P388D1 culture, or in mere culture medium for 4 or 8 days. The dissolution of the fibers was determined by measuring the amounts of silicon (Si), iron (Fe), and aluminum (Al) in the medium. There were no differences in the diameter of the fibers, but a clear difference existed in the length of the short and long fibers. The dissolution of Si, Fe, and Al was more pronounced from experimental rockwool than from commercial glasswool fibers. The dissolution of Si was always greater in mere culture medium than in rat AM culture. Moreover, the dissolution of Si was greater from the long fibers than from the short ones. On the contrary, the dissolution of Fe and Al in AM culture exceeded that in mere culture medium. The dissolution of Si, Fe, and Al from both fibers in P388D1 culture was similar to their dissolution in rat AM culture. The fibers were also effectively phagocytized by the macrophages. The present results together suggest that the intracellular and the extracellular dissolutions of man-made vitreous fibers differ from each other.

Aluminum↗
PubMed1994

Spectral pattern recognition of improved voice quality.

The self-organizing map (a neural network) was applied to the spectral pattern recognition of voice quality in 34 subjects: 15 patients operated on because of insufficient glottal closure and 19 subjects not treated for voice disorders. The voice samples, segments of sustained /a/, were perceptually rated by six experts. A self-organized acoustic feature map was first computed from tokens of /a/ and then used for the analysis of the samples. The locations of the samples on the map were determined and the distances from a normal reference were compared with the perceptual ratings. The map locations corresponded to the degree of audible disorder: the samples judged as normal were overlapping or close to the normal reference, whereas the samples judged as dysphonic were located further away from it. The comparison of pre- and postoperative samples of the patients showed that the perceived improvement of voice quality was also detected by the map.

Adult↗
PubMed1994

Workers' exposure to airborne bacteria and endotoxins at industrial wastewater treatment plants.

A study of sewage workers' exposure to airborne culturable bacteria and inhaled endotoxins was performed at nine waste-water treatment plants that treat mainly industrial effluents. Airborne endotoxins were collected on glass fiber filters and analyzed using a chromogenic limulus assay. Endotoxin concentrations measured in the immediate vicinity of the waste-water treatment process varied from 0.1 to 350 ng/m3. The eight-hour time weighted average concentrations of endotoxin to which workers were exposed exceeded the suggested exposure limit (30 ng/m3 endotoxin) at four of the plants. Air samples of culturable bacteria concentrations varied between 10 and 10(5) colony-forming units/m3. Of the particles carrying culturable bacteria, 88% had an aerodynamic diameter of less than 4.7 microns. The most common genera of airborne gram-negative bacteria were acinetobacter, citrobacter, enterobacter, klebsiella, and pseudomonas. High levels of exposure to bacteria and bacterial endotoxin usually were related to certain phases of the treatment process. The microbiological contamination of air was highest near the inlets where incoming wastewater entered the basins, in the sludge treatment area, and inside the biofilter tower. In these spaces it is necessary to control and reduce exposure to airborne bacteria and endotoxin at wastewater plants.

Air Microbiology↗
PubMed1993

Volatile metabolites in occupational exposure to organic sulfur compounds.

Dimethyl sulfide in breath was determined by the gas chromatographic method in 14 persons exposed to organic reduced sulfur compounds in sulfate pulp mills. Dimethyl sulfide concentrations in breath (range 0.04-0.69 cm3/m3 were compared to the combined workplace concentrations of methyl mercaptan, dimethyl sulfide and dimethyl disulfide. This method of analysis proved to be a practical noninvasive way to assess recent exposure, and therefore it should be applicable to workplaces contaminated with organic sulfur compounds in the pulp industry.

Air Pollutants, Occupational↗
PubMed1993

Exposure of sprayers and plant handlers to mevinphos in Finnish greenhouses.

The exposure of sprayers and plant handlers to mevinphos, a toxic organophosphate insecticide, was evaluated in eight flower-growing greenhouses. The purpose was to assess an appropriate re-entry interval for mevinphos after its application in greenhouses. Inhalational and dermal exposure was measured during two days after application by measuring mevinphos in the greenhouse air and on the foliage. Workers' dermal exposure was measured with patch and handwash samples. The method of application considerably affected the levels of mevinphos in greenhouse air and on the foliage. The occupational exposure was measured with patch and handwash samples. The method of application considerably affected the levels of mevinphos in greenhouse air and on the foliage. The occupational exposure limit for mevinphos in Finland (100 micrograms/m3) was exceeded during the use of nonthermal foggers. Usually, however, the concentration of mevinphos in the breathing zone of the workers was below 10 micrograms/m3 9-12 hr after application. Mevinphos disappeared rapidly from greenhouse air and from the foliage after application, with a half-life of 9.2 hr. These data provide evidence that the main route of exposure to mevinphos is dermal, a conclusion supported by the excellent correlation between dermal exposure and the amount of mevinphos on the foliage. The calculated re-entry interval for mevinphos was approximately 4.5 hr. However, that interval is likely to be too short in practice because the risk of dermal exposure is considerable for more than 10 hr after the application of mevinphos.

Adult↗
PubMed1993

Self-organized acoustic feature map in detection of fricative-vowel coarticulation.

The self-organizing map, a neural network algorithm of Kohonen, was used for the detection of coarticulatory variation of fricative [s] preceding vowels [a:], [i:], and [u:]. The results were compared with the psychoacoustic classification of the same samples to find out whether the map had extracted perceptually meaningful features of [s]. The map distinguished samples of [s] in front of [u:] from those in front of [a:] or [i:] throughout the fricative duration. Samples of [s] preceding [a:] and [i:] were distinguished from each other only just before (about 40 ms) the vowel onset. The results agreed with the perceptual classifications. Most judgments (82%) of [s] in front of [u:] were correct, and this variant of [s] was recognized from the first and second halves of segmented fricatives equally well. Samples of [s] in front of [a:] and [i:] were distinguished from each other less accurately. When halves of segmented [s] were perceptually judged, the differentiation between the following [a] and [i] was possible only on the basis of the second half of the fricative. The results demonstrate that the self-organizing map is a useful tool for the extraction of intersubject regularities in speech spectra. The map also provides an easily understandable, on-line, visualization of speech that can be used as feedback in therapy and education.

Acoustic Stimulation↗
PubMed1993

Acoustic pattern recognition of fricative-vowel coarticulation by the self-organizing map.

Word-initial samples of fricative [s] preceding vowels [a:], [ae:], [e:], [i:], [u:], [o:], and [y:] in Finnish words were studied with the self-organizing map. An acoustic map was first calculated from speech samples of women without speech disorders, and then the [s] samples were measured on this map. In all 10 subjects the [s] samples preceding the rounded vowels [u:] and [o:] clearly differed from the samples in front of unrounded [a:], [ae:], [e:], and [i:]. The coarticulatory phenomena observed on the map were due to changes in the composition and stability of the fricative spectrum.

Adult↗
PubMed1993

Acoustic pattern recognition of /s/ misarticulation by the self-organizing map.

The [s] samples of 11 women, psychoacoustically classified as acceptable/unacceptable, were studied with the self-organizing map, the neural network algorithm of Kohonen. The measurement map had been previously computed with nondisordered speech samples. Fifteen-component spectral vectors, analyzed with the map, were calculated from short-time FFT spectra at 10-ms intervals. The degree of audible acceptability correlated with the location of the sample on the map. Spectral model vectors in different map locations depicted distinguishing spectral features in the [s] samples analyzed. The results demonstrate that self-organized maps are suitable for the extraction and measurement of acoustic features underlying psychoacoustic classifications, and for on-line visual imaging of speech.

Adolescent↗
PubMed1992

Dysphonia detected by pattern recognition of spectral composition.

The vowel [a:] in a test word, judged normal or dysphonic, was examined with the Self-Organizing Map; the artificial neural network algorithm of Kohonen. The algorithm produces two-dimensional representations (maps) of speech. Input to the acoustic maps consisted of 15-component spectral vectors calculated at 9.83-msec intervals from short-time power spectra. The male and female maps were first calculated from the speech of healthy subjects and then the [a:] samples (15 successive spectral vectors) were examined on the maps. The dysphonic voices deviated from the norm both in the composition of the short-time power spectra (characterized by the dislocation of the trajectory pattern on the map) and in the stability of the spectrum during the performance (characterized by the pattern of the trajectory on the map). Rough voices were distinguished from breathy ones by their patterns on the map. With the limited speech material, an index for the degree of pathology could not be determined. A self-organized acoustic map provides an on-line visual representation of voice and speech in an easily understandable form. The method is thus suitable not only for diagnostic but also for educational and therapeutic purposes.

Adolescent↗
PubMed1991

Occupational exposure of forest workers to glyphosate during brush saw spraying work.

The purpose of this study was to measure forest workers' exposure to the herbicide glyphosate during silvicultural clearing work done with brush saws equipped with pressurized herbicide sprayers. Both the exposed (study) group and the nonexposed (control) group contained five persons who were medically examined before and after their 1-week working period (including laboratory tests) for possible health effects. In addition, exposure to glyphosate was measured in the study group from samples taken from the workers' breathing zone and from urine samples collected during the afternoons of the workweek. The laboratory tests and urinary glyphosate analyses were repeated for the exposed group 3 weeks later, when the men had entirely stopped their work with the herbicide. Exposure to glyphosate through the workers' breathing zone was low. The highest value found was 15.7 micrograms/m3. In this study, a biological monitoring method was also developed to monitor the workers' exposure to glyphosate. Urine concentrations were under the gas chromatographic detection level of less than 0.1 ng/microL (less than 1.0 mumol/L). No major differences were noted, either in medical examinations or in the laboratory tests performed, between the exposed and control groups before and after the work period.

Adult↗
PubMed1988

Atrial natriuretic peptide (ANP) in rat gastrointestinal tract.

Acid extracts of rat stomach and small intestine contained 8.6 +/- 3.7 and 39 +/- 15 ng/g of immunoreactive atrial natriuretic peptide (ANP). When studied by gel filtration and reverse-phase high-performance liquid chromatography, the stomach immunoreactivity consisted of multiple components, whereas the small intestine contained mostly proANP and ANP 1-28-like material. These findings indicate that ANP may have a role in the physiology of the gastrointestinal tract, e.g. in the regulation of water and electrolyte absorption.

Animals↗
PubMed1988

Urinary atrazine metabolites as indicators for rat and human exposure to atrazine.

Rats were given atrazine (2-chloro-4-ethylamino-6-(isopropylamino)-s-triazine) in drinking water for 1 or 3 weeks at 0.1 (0.45 mM), 0.2 (0.9 mM) or 0.5 g/l (2.3 mM) concentrations of the commercial agent. They excreted at both time points as the principal metabolite 2-chloro-4-ethylamino-6-amino-s-trazine in a dose-dependent fashion. The same urine test was applied on 6 railway men engaged in the weeding operation of railway lines with known atrazine exposure measured with hygienic techniques in their breathing zone. The spectrum of their atrazine metabolites was comprised of fully N-dealkylated atrazine and 2-chloro-4-ethylamino-6-amino-s-triazine. The sum of the two urinary metabolites reflected quantitatively the exposure.

Administration, Oral↗
PubMed1987

Urinary thiosulphate as an indicator of exposure to hydrogen sulphide vapour.

Urinary thiosulphate analysed as its bromobimane complex by liquid chromatography revealed quantitatively a preceding hydrogen sulphide gas exposure. The highest thiosulphate concentrations were detected 15 h after the exposure. Controls without a contact to sulphides showed low excretion rates of thiosulphate so that exposures clearly below the fatal hydrogen sulphide gas concentrations could be detected. The urinalysis can therefore be used in the occupational health care as well as for forensic ends.

Air Pollutants, Occupational↗
PubMed1987

Total concentrations of dust in the air during farm work.

Total concentrations of dust in the air of work environments were measured on 20 Finnish farms during 1980-82. On 8 farms the main line of production was dairy farming, on 5 farms it was pig farming, on 4 farms poultry farming and on 3 farms grain production. Dust was measured by the gravimetric method according to the Finnish standard. Results were compared to the threshold limit value (TLV), which for inorganic dust is 10 mg/m3, and for organic dust 5 mg/m3. Mean concentrations of dust in the breathing zone exceeded the TLV for organic dust in all farm buildings, piggeries and poultry yards with coops having the highest mean concentrations, 12.6 mg/m3 and 12.8 mg/m3, respectively. Mean total concentrations of dust during seed dressing, harrowing, rolling and emptying the grain drier were 31.4, 14.0, 18.2 and 20.0 mg/m3, respectively. During sowing and haymaking, the total concentrations of dust were also high occasionally.

Agricultural Workers' Diseases↗
PubMed1987

Dust exposure in piggeries.

The aim of this study was to measure the total concentrations of dust in piggeries and to analyze the components of the dust. Dust samples were taken from 15 fattening pig and/or sow farms situated in southern Finland. Total concentrations of dust were measured by the gravimetric method; the organic portion of the total dust was determined by ashing, mass distribution determined by Cascade Centripeter sampler, count distribution by optical analyzer, and toxic metals of the total dust by atomic absorption spectrophotometer. The mean concentrations of total dust at stationary sampling sites were higher on fattening pig farms (9.4 +/- 1.7 mg/m3) (mean +/- SE) than on sow farms (5.2 +/- 1.2 mg/m3). The concentrations in the breathing zone were 8.6 +/- 2.7 mg/m3 and 7.9 +/- 3.2 mg/m3, respectively. The proportion of organic dust was about 90% in the dust of pig units. The mass median aerodynamic diameter of the dust particles in pig fattening units was 11 micron. Concentrations of toxic metals (nickel, cobalt, copper, zinc, chromium, cadmium) were very low.

Agricultural Workers' Diseases↗