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Biomedical subjects

J Kang

Publications and source records attributed to J Kang.

At least 235 records · Page 13Linked to original sources
PubMed1993

[Postprandial hypotension in Parkinson's disease--the incidence and risk factor].

To clarify the incidence and risk factor of postprandial hypotension (PPH) in Parkinson's disease, a 75g oral glucose tolerance test (OGTT) was carried out in 23 patients (Hoehn-Yahr score II in 2, III in 18 and IV in 3) without postprandial symptoms. We defined the patients whose systolic blood pressure fell more than 20 mmHg during the 75g OGTT as group I and less than 20 mmHg as group II. In 14 patients with Parkinson's disease (61%), the systolic blood pressure fell more than 20 mmHg without symptoms. There were no significant differences in in age, disease duration, clinical stage or antiparkinsonian drug between groups I and II. However, the baseline systolic and diastolic blood pressures were significantly higher in group I than in group II. In group I patients, the maximum decrease in systolic blood pressure was seen after more than 60 minutes and serum insulin response was higher than in group II patients from 60 to 120 min. Systolic blood pressure declined accompanied by the rise of insulin. These results suggest that PPH occurs at high incidence in patients with moderately severe Parkinson's disease, and that high baseline blood pressure and abnormally high insulin response to glucose load may play a role, while medications for Parkinson's disease may not.

Aged↗
PubMed1993

[A comparative trial of hemodynamics and pulmonary function in patients with chronic lung disease complicated with or without pulmonary hypertension during exercise].

In order to determine the hemodynamics and pulmonary function during exercise, 20 patients with chronic lung disease complicated with (group A) or without (group B) pulmonary hypertension were studied. FEV1% in group A was lower than that in group B at rest, the increase in VE, VO2, O2-pulse in patients with pulmonary hypertension were lower than in patients without it during exercise. We speculated that exercise ability in patients with chronic lung disease may be effected by not only ventilation but also increased pulmonary arterial pressure.

Aged↗
PubMed1993

[Effects of tetrandrine on pulmonary hypertension in patients with chronic obstructive pulmonary disease].

Tetrandrine were given to nine patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease and the effects of central hemodynamics and blood gases were studied. 60 minutes after the administration of the medicine, total pulmonary vascular resistance (TPVR) and pulmonary artery mean pressure (mPAP) were reduced by 23% (from 59.2 KPa.s/L to 45.6k Pa.s/L (1 kPa = 7.5 mmHg, P < 0.05) and 15% (from 4.0 kPa to 3.4 kPa, P < 0.05) respectively. Systemic artery mean pressure (mSAP) only decreased by 4.9%. There were no significant differences between the values of cardiac output (co), PaO2, SaO2 before and after the administration of tetrandrine.

Alkaloids↗
PubMed1992

Long term expression of IL-4 in vivo using retroviral-mediated gene transfer.

Th cell subsets regulate immune responses by cell-cell interaction and secretion of cytokines. IL-4 is one of the cytokines secreted by Th cells important for cellular and humoral, particularly IgG1 and IgE responses. To study the role of IL-4 in T cell development and regulation of immune responses in vivo, low IgE-responder C57BL/6 mice were reconstituted with bone marrow cells that had been infected with recombinant retrovirus expressing a high level of IL-4. The reconstituted mice expressed retroviral IL-4 transcripts (9/10) even 8 mo postreconstitution. Physiologically significant levels of IL-4 were detected in the majority of the provirus-positive animals tested (5/8). Ectopic expression of exogenous IL-4 in hematopoietic cells had dramatic effects on T cell development resulting in changes in CD4:CD8 ratios. Moreover, the levels of serum IgG1 and, with antigenic stimulation, IgE were also increased. These results demonstrate that the retrovirus gene transfer system can be used to study the effects of ectopic cytokine gene expression in vivo on Ig isotype regulation and T helper cell subset differentiation.

Animals↗
PubMed1992

Modulation of net outward current in cultured neurons by angiotensin II: involvement of AT1 and AT2 receptors.

In this study we have used whole-cell, voltage-clamp procedures to determine the effects of angiotensin II (AII) on net outward current (I(no)) in neurons co-cultured from the hypothalamus and brainstem of 1-day-old rats. Ino is the sum of all inward and outward membrane currents (minus Na+, which is blocked by tetrodotoxin) which occur during the repolarization phase of the action potential. We have determined that AII elicits two separate effects on I(no) in cultured neurons. AII caused a reversible and concentration (0.1 nM-10 microM)-dependent increase in I(no). This effect is inhibited by the AT2 receptor-selective antagonists, PD123177 and PD123319 (both 100 nM), but not by the AT1-selective receptor blocker, DuP753 (Losartan; 100 nM), and so it is mediated by AT2 receptors. In a smaller number of neurons AII induced a reversible and concentration (0.01 nM-10 microM)-dependent decrease in I(no) that was blocked by Losartan (100 nM) but not by PD123177 (100 nM). Thus the decrease in I(no) is mediated by AT1 receptors. Additionally, some neurons displayed both AT1- and AT2 receptor-mediated effects on I(no). Our results demonstrate two distinct actions of AII on membrane ionic currents in cultured neurons, effects that are mediated by different AII receptor subtypes.

Action Potentials↗
PubMed1992

Ectopic lymphokine gene expression in human peripheral blood lymphocytes in vivo.

An animal model to study the effects of ectopic expression of cytokines involved in cell growth and differentiation has been established. Retrovirus vectors containing the human interleukin 6 cDNA were used to produce high titer virus-producing lines. Human peripheral blood lymphocytes (hPBLs) were successfully infected with the retrovirus and engrafted into severe combined immunodeficient mice. The majority of the animals were engrafted with hPBLs, as determined by the presence of human glucose phosphate isomerase. Furthermore, six of seven mice engrafted with hPBLs infected with high titer virus and detectable hPBLs present in the spleen expressed the retroviral human interleukin 6 gene. Importantly, human interleukin 6 protein was expressed at physiologically significant levels in these mice. These results demonstrate that models for human disease and immunotherapy involving retrovirus-mediated gene transfer into human cells can be developed in mice.

Animals↗
PubMed1992

Identification of cDNAs encoding two novel rat pancreatic serine proteases.

Serine proteases (SPs) are a family of physiologically important and versatile enzymes. We designed degenerated oligodeoxyribonucleotide primers derived from the consensus amino acid aa sequences of the active site of mammalian SPs, to selectively amplify in a polymerase chain reaction (PCR) cDNA fragments coding for SPs. We used poly(A)+ RNA from rat pancreas to obtain the cDNA. Two of the amplified cDNA fragments encode novel SPs. The full-length nucleotide sequence of both cDNAs was also obtained by PCR. The high degree of homology to trypsins and elastases suggests that the cDNAs encode a trypsin-like and an elastase-like SP, respectively. Both mRNAs were also found to occur, to a lesser extent, in spleen, as was the case for the mRNAs of other rat pancreatic SPs.

Amino Acid Sequence↗
PubMed1992

[A case of pontine hemorrhage showing hemiasomatognosia].

We reported a case of pontine hemorrhage showing hemiasomatognosia. A 74-year-old, right-handed man was admitted to our hospital complaining of numbness of left upper and lower extremities. Neurological examination revealed marked disturbance of superficial and deep sensation of left half of his body without hemiparesis and consciousness disturbance. Neuropsychologically, he had experience of having lost the perception of his left upper limb, which was referred to "conscious hemiasomatognosia" by Frederiks. Brain CT and MRI showed a pontine hematoma involving the right medial lemniscus, the right spinothalamic tract and the right medial longitudinal fasciculus. One week after the onset, hemiasomatognosia disappeared with improvement of sensory disturbance. These indicate that this form of hemiasomatognosia may be associated with transient blockage of somesthetic input.

Aged↗
PubMed1992

The effects of okadaic acid and calyculin A on thrombin induced platelet reaction.

Okadaic acid and calyculin A, specific and cell permeable inhibitors of protein phosphatase 1 and 2A, inhibited aggregation, secretion and delta [Ca++]i in thrombin stimulated platelets. The inhibitory effect of calyculin A (IC50: 3.6-4.8nM) was about two hundred times more potent than that of okadaic acid (IC50: 0.8-1.3 microM), which is consistent with the difference of the reported Ki values for protein phosphatase 1. These phosphatase inhibitors and PGI2 synergistically enhanced the phosphorylation of 50kDa protein (P50), which is solely related to the inhibition of platelet reaction. These results indicate that serine/threonine protein phosphatase 1 might play a role in platelet activation.

Adenosine Triphosphate↗
PubMed1992

[Alteration of atrial natriuretic peptide in progressive muscular dystrophy with congestive heart failure].

We measured plasma levels of atrial natriuretic peptide (ANP) in 9 patients of Duchenne muscular dystrophy (DMD) and 3 patients of Becker muscular dystrophy with congestive heart failure (CHF). Administration of digitalis, catecholamine and angiotensin converting enzyme inhibitor resulted in decrease of ANP levels as well as improvement of clinical symptoms of CHF and cardiomegaly. Four DMD patients whose ANP levels were more than 200 pg/ml after the treatment of CHF showed poor prognosis. These results suggest that ANP is a useful marker for the treatment of CHF in progressive muscular dystrophy.

Adolescent↗