Biomedical subjects

J Kalivas

Publications and source records attributed to J Kalivas.

At least 19 recordsLinked to original sources

PubMed1995

Solar purpura appearing in a patient with polymorphous light eruption.

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Adult↗

PubMed1992

Retinoids: uses and abuses.

There is no doubt that modern retinoids are a two-edged sword. While they appear to normalize many abnormal biologic processes, i.e. modulate cellular differentiation and cellular proliferation, at the same time they can severely "abnormalize" other processes, i.e. embryonic organogenesis. Pharmaceutical ingenuity in separating their toxicity from their efficacy will determine their ultimate value to the therapist.

Cell Differentiation↗

PubMed1990

Urticaria: clinical efficacy of cetirizine in comparison with hydroxyzine and placebo.

Chronic urticaria is a problem for both physician and patient. In an effort to avoid the risks associated with corticosteroid treatment, many first-generation H1-receptor antagonists have been tried and found to induce undesirable levels of sedation when given in amounts sufficient to control urticaria. Cetirizine, a pharmacologically active oxidized metabolite of hydroxyzine, was developed to provide selective H1-receptor inhibition without depression of the central nervous system. In a 4-week, multicenter, double-blind, placebo-controlled safety and efficacy study, cetirizine, in a once-a-day dose (5 to 20 mg), was equivalent in efficacy to hydroxyzine in divided doses (25 to 75 mg/day). The incidence of somnolence in the cetirizine group was not significantly different from that of the placebo group. However, in the hydroxyzine group, the incidence of somnolence was significantly higher than that in the placebo group (p = 0.001). The results of this study demonstrate that cetirizine has a greater safety margin over the older parent drug hydroxyzine.

Adolescent↗

PubMed1989

Personality factors as predictors of therapeutic response to cryosurgery in patients with warts.

Fifty patients with warts were treated with cryotherapy and given a 100-item questionnaire, The Tennessee Self-Concept Scale, to complete. Responses from 42 patients on whom follow-up data were available were subjected to computer analysis. The answers to eight of the questions differed significantly between treatment cures (23) and treatment failures (19). Further analysis of two of the eight questions showed that it may be possible to use them to predict cryosurgical treatment success or failure in up to 100% of cases.

Adult↗

PubMed1988

Solar purpura.

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Adult↗

PubMed1985

Histoplasma panniculitis.

We encountered two cases of disseminated histoplasmosis with cutaneous involvement. The clinical and histopathologic findings were those of panniculitis. Primary pulmonary histoplasmosis typically induces a hypersensitivity panniculitis remote from the site of infection. In our cases of disseminated disease, however, the organisms were present in the skin and subcutaneous fat.

Adipose Tissue↗

PubMed1983

Doing battle with impulsive disorders.

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Aversive Therapy↗

PubMed1982

Technetium scanning in Kaposi's sarcoma and its simulators.

The clinical picture of ulcerated purple plaques on the legs often suggests several diagnoses: Kaposi's sarcoma, stasis dermatitis, atrophie blanche (livedoid vasculitis), and a poorly understood condition called acroangiodermatitis of Favre-Chaix (pseudo-Kaposi's sarcoma). Even the skin biopsy may not always be conclusive. We describe our experience with three patients with pseudo-Kaposi's sarcoma, one with "true" Kaposi's sarcoma and two with atrophie blanche. Clinical and histopathologic similarities among these three conditions pointed up the need for additional confirmatory studies, i.e., isotope scanning. The technetium scan was positive in both Kaposi's sarcoma and pseudo-Kaposi's sarcoma but negative in atrophie blanche.

Acrodermatitis↗

PubMed1980

Hereditary acrodermatitis enteropathica in an adult.

The condition of a 33-year-old woman who had a history of blisters following trauma on the hands, knees, and feet since 1 year of age previously had been diagnosed as epidermolysis bullosa. She also had psoriasiform plaques, a pustular crusted periorificial eruption, paronychia, alopecia, and photophobia. She had had minimal history of diarrhea. A markedly decreased serum zinc level was found, and treatment with zinc sulfate was instituted, resulting in clearing of all clinical manifestations. Since patients with hereditary acrodermatitis enteropathica may have minimal or no diarrhea and the correct diagnosis may be long delayed, the condition should not be considered strictly a disease of children.

Acrodermatitis↗

PubMed1980