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Biomedical subjects

J Körner

Publications and source records attributed to J Körner.

11 recordsLinked to original sources
PubMed1992

Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder.

Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.

Alleles↗
PubMed1990

RFLP alleles at the tyrosine hydroxylase locus: no association found to affective disorders.

Affective disorders are usually referred to as being inherited multifactorially. The contribution of a gene locus in illnesses displaying multifactorial inheritance may be assessed by searching for associations of alleles to the illness. The tyrosine hydroxylase gene encodes the rate-limiting enzyme in the synthesis of catecholamines and might be a candidate for causing the manic-depressive phenotype. Therefore, we tested 88 patients with affective disorders and 99 healthy control persons for association of restriction fragment length polymorphism (RFLP) alleles at the tyrosine hydroxylase locus. The comparison of allele or genotype frequencies did not reveal any significant differences between the two groups.

Adolescent↗
PubMed1989

[Norrie syndrome: identification of carriers by segregation analysis with flanking DNA markers].

Norrie disease is an X-linked recessive disorder. Affected males present with congenital blindness. Additionally, hearing loss and psychotic behavior may occur at any time. Since carriers are clinically healthy, they can only be identified by genetic means. Daughters of carriers or sisters of affected males have an à priori 50% risk of being carriers themselves. Close linkage has been found between the Norrie disease locus (NDP) and the DNA locus DXS7 mapped to Xp11.3. For genetic counselling, this linkage relationship allows carriers of the disease to be identified in informative families. We describe a large pedigree with Norrie disease. Segregation analysis was carried out with DXS7 and a second flanking marker, DXS255, both linked to NDP. In this way, three females at risk were identified who had a high probability of being carriers for Norrie disease.

Adult↗
PubMed1989

[Critique of the "therapeutic ego split"].

The technical relevance of the concept of a therapeutic ego split is rigorously examined. In the author's view, the distinction between a neurotic transference and a non-neurotic working alliance serves the therapist as a defense against anxiety rather than as a clarification of his intricate involvement with the patient.

Ego↗
PubMed1987

[Spontaneous liver rupture in eclampsia].

We report on a case of a 34-year old nullipara who suffered from rupture of the liver during eclampsia and survived despite most serious complications. Most cases of rupture of a non-traumatic subcapsular haematoma of the liver during pregnancy are associated with symptoms of pre-eclampsia. The pathogenesis of this severe complication as well as diagnostic imaging and surgical treatment are discussed. The classical trias of pre-eclampsia, epigastric pain and sudden circulary collapse may vary considerably. Since early diagnosis is crucial for maternal and foetal outcome, a subcapsular haematoma of the liver should be considered in women during pregnancy and childbed presenting with pre-eclampsia and upper abdominal pain. Here ultrasonographic imaging is a valuable and readily available diagnostic tool for the obstetrician.

Adult↗
PubMed1986

Determination of tenoxicam in human plasma by high-performance liquid chromatography.

A high-performance liquid chromatographic method for the determination of tenoxicam in plasma has been developed. Tenoxicam was extracted from buffered plasma (pH 3 or 4, respectively) with dichloromethane and the evaporated extracts were analysed on a C18 reversed-phase column using a methanol-phosphate buffer mobile phase and with UV detection at 371 nm. The detection limit was 20 ng/ml using a 0.5-ml sample. The method is selective with respect to the 5'-hydroxy metabolite, which is present in plasma after multiple administration of tenoxicam; this metabolite may also be determined using this procedure.

Anti-Inflammatory Agents, Non-Steroidal↗