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Biomedical subjects

J K Wing

Publications and source records attributed to J K Wing.

At least 73 records · Page 4Linked to original sources
PubMed1975

The ethics of clinical trials.

In summary, the discussion by Professors Helmchen and Müller-Oerlinghausen of the morality of clinical trials has emphasized a point that is frequently overlooked. It is an essential to consider those situations in which it might be unethical not to conduct a trial as it is to be concerned about the ways in which trials might restrict the rights of the individuals taking part in them. They and I have dealt mainly with the first of these two issues because it has been relatively neglected. The second is, of course, equally important and has rightly received much attention. Both matters deserve further public discussion.

Clinical Trials as Topic↗
PubMed1975

[Evaluation of the public health services concerned with the treatment of schizophrenic patients: an epidemiological approach].

Diagnostical problems are of importance for the organization of mental health services. The WHO data show that criteria for diagnosing schizophrenia are rather broader in Moscow than in London and this must be borne in mind, when comparing services. The rehabilitation system is more thorough in Moscow and Leningrad than in the U. K. So far as the central syndromes of schizophrenia are concerned the basic approach in two countries is practically similar. Both assume an interaction between a biological abnormality which is liable to be chronically handicapping and a social environment.

Delivery of Health Care↗
PubMed1974

Psychiatry in the Soviet Union.

The services for chronically handicapped people with psychiatric disorders in the Soviet Union are described. The system is based upon a network of community units, each of which includes a day centre, a follow-up clinic, and a sheltered workshop. British services could profitably learn from the experience of these units. The diagnostic system used by many Soviet psychiatrists is different from that incorporated in the International Classification of Diseases. In particular, the term "schizophrenia" is used to describe conditions which British psychiatrists would label in other ways.This clinical difference partly explains the different concept of "criminal responsibility," but another large component of the difference is political rather than medical. There are also variations from British practice in certain juridical procedures. These differences together make Soviet psychiatric practice in the case of political dissenters unacceptable to most British psychiatrists. It is too soon to say that frank discussions of these matters could not lead to improvement. British and Soviet psychiatrists still have something to learn from each other.

Alcoholism↗
PubMed1973

Outpatient maintenance of chronic schizophrenic patients with long-acting fluphenazine: double-blind placebo trial. Report to the Medical Research Council Committee on Clinical Trials in Psychiatry.

A double-blind placebo trial of fluphenazine decanoate, a long-acting phenothiazine, was carried out to determine its value in maintenance therapy of chronic schizophrenic outpatients already established on the drug for a minimum period of eight weeks. In low doses it was significantly more effective than placebo in preventing relapse and admission to hospital. Relapse was accompanied by a resurgence of specifically schizophrenic symptoms and by an increase in abnormalities described by the relatives. There was no difference between the experimental and control groups in the treatment required for depression. The group on active medication required more treatment for Parkinsonism, but this difference did not reach statistical significance.In the context of a well-run special clinic for outpatient follow-up of chronic schizophrenic patients these results confirm the usefulness of long-acting fluphenazine. By inference, the benefit of this treatment highlights the need for adequate community services to deal with the residual chronic disabilities which are characteristic of these patients.

Adolescent↗
PubMed1971

Trial of maintenance therapy in schizophrenia.

A double-blind, placebo-controlled trial was carried out to determine the value of maintenance therapy with phenothiazines in a population of outpatients who had recently recovered from an acute episode of schizophrenia. The drug was shown to be significantly more effective than the placebo in preventing relapse. The relationship of the trial patients to the population from which they were selected was defined in terms of clinical, historical, and social data. Maintenance therapy seems of little value in patients with a good prognosis and in the severely ill, but it is of value in the indeterminate group between these two extremes.

Acute Disease↗