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Biomedical subjects

J K Trinkle

Publications and source records attributed to J K Trinkle.

At least 55 records · Page 3Linked to original sources
PubMed1983

Comparison of flow differences among venous cannulas.

1. Double caval cannulas with snares provide maximum venous decompression, especially of the superior vena cava. Decompression of the right side of the heart is passive and in the heart being perfused requires venting of the right atrium by release of tapes or atrial suction. 2. Double caval cannulas without snares provide good and consistent venous and atrial decompression. The ventricle is decompressed well except when the perfused heart is in the circumflex position. 3. A large single cannula (e.g., USCI 40F) can decompress both the venous system and right side of the heart, although venous and atrial drainage are much less efficient when the heart is in the circumflex position. 4. The Sarns 51F cavoatrial cannula decompressed the venous system as efficiently as the double caval cannulas. In fact, decompression of the atrium and ventricle were consistently much better with the cavoatrial cannula than with any of the other methods. 5. Efficient venous and myocardial decompression using the 51F cavoatrial cannula requires the atrial drainage ports to be positioned in the upper middle section of the atrium. Clinically, the cannula position is correct when both the single and double marking bands on the cannula are outside the atrium.

Animals↗
PubMed1982

Comparison of roller pump versus pressurized bag administration of potassium cardioplegic solution.

We sought to determine the relative efficacy of administering cardioplegia by the pressurized bag versus roller pump technique. Fourteen dogs were placed on cardiopulmonary bypass at 30 degrees C and subjected to 2 hours of cardioplegic arrest. Group 1 (7 dogs) was administered cardioplegic solution from a plastic bag under pressure into the ascending aorta every 20 minutes for the 2-hour period, and Group 2 (7 dogs) was given cardioplegia by means of a roller pump. Myocardial temperature decreased in Group 1 to 13.4 degrees C following administration of the cardioplegic solution, and to 13.1 degrees C in Group 2 (not significant). These temperatures were reached in 3.0 minutes in Group 1 and 1.9 minutes in Group 2 (p less than 0.03). Aortic root pressures during cardioplegic infusion were 31 +/- 2 mm Hg in Group 1 versus 46 +/- 2 mm Hg in Group 2 (p less than 0.01). No significant differences between groups were noted in myocardial distribution of cardioplegia, myocardial blood flow or metabolism, or left ventricular hemodynamics. We conclude that both methods of administering cardioplegia lowered myocardial temperature adequately and protected the myocardium for a period of 2 hours in these normal hearts. The roller pump method facilitated faster cooling and produced significantly higher aortic perfusion pressures, however, which may be important in hearts with coronary stenosis.

Adenosine Triphosphate↗
PubMed1981

Management of transmediastinal gunshot wounds.

Gunshot wounds that transverse the mediastinum are major management problems for two primary reasons: (1) multiple injuries to vital structures are common and (2) the operative approach to control hemorrhage may not afford the optimum exposure to repair the various injuries encountered. We devised a management plan whereby patients in hemodynamically unstable condition underwent immediate operation and patients in stable condition underwent a rapid work-up to evaluate the organs at risk for injury including angiography, esophagoscopy, esophagography, bronchoscopy, and pericardial exploratory surgery while under local anesthesia. A total of 76 patients were treated. Thirty-three patients in unstable condition underwent immediate thoracotomy for hemorrhage or shock or median sternotomy for cardiac tamponade. Multiple organs were injured (average 2.7) and the mortality rate was high (12 of 33) because of the severity of the injuries. Twenty-seven of 43 patients in stable condition required operation after the systematic evaluation disclosed injuries to the great vessels (11), esophagus (9), trachea and bronchi (6), and heart (6). Three patients died of delayed complications (6.9%). The 16 patients who were in stable conditions and had no demonstrable injury were closely followed without operation with one complication and one death from an associated abdominal injury. A management plan for this difficult subset of patients with penetrating thoracic trauma is detailed.

Adult↗
PubMed1981

Does lower systemic temperature enhance cardioplegic myocardial protection?

This study was performed to determine if systemic temperature affects the rate of cooling and rewarming of the myocardium between infusions of cold potassium cardioplegic solution and if it alters the degree of myocardial protection. Twenty-one dogs underwent cardiopulmonary bypass and 3 hours of ischemic arrest produced by infusing 0 degrees to 4 degrees C potassium cardioplegic solution every 20 minutes. The animals were perfused at different systemic temperatures--Group A, 23 degrees C; Group B, 30 degrees, C; and Group C, 37 degrees C. Myocardial temperature decreased to 11 degrees C in Groups A and B as compared with 13 degrees C in Group C immediately after infusion of the potassium cardioplegic solution (p < 0.0007). Myocardial temperature increased to 19 degrees, 21 degrees, and 26 degrees C in Groups A, B, and C (p < 0.000005) 20 minutes after infusion. Myocardial adenosine triphosphate (ATP) concentration significantly decreased, from 6.69 to 3.56 mumoles/gm (p < 0.0003) in Group B and from 4.99 to 2.80 (p < 0.005) in Group C at the end of 3 hours of cardioplegic arrest. Myocardial glycogen levels also significantly decreased, from 1.156 to 446 mg% (p < 0.003) in Group B and from 811 to 439 mg% (p < 0.04) in Group C. Myocardial ATP and glycogen did not decrease significantly in Group A during the period of arrest. Myocardial lactate values increased more in Groups B and C during the arrest period than in Group A. 12.6 versus 6.5 mumoles/gm (p < 0.03). Moderate systemic hypothermia, therefore, appears to enhance the myocardial protection of potassium cardioplegia.

Adenosine Triphosphate↗
PubMed1981

Carcinoma of the esophagus. An aggressive one-stage palliative approach.

We reviewed the records of 44 consecutive patients with advanced esophageal carcinoma treated at either a Veterans Administration or a city-country hospital. The patients, 38 men and six women, ranged in age from 27 to 72 years and had been referred for operative management. The average duration of dysphagia was 5 months. All patients underwent a one-stage esophagogastrectomy with esophagogastrostomy. The last 34 patients also had a modified fundoplication. Lesions at the gastroesophageal junction were approached via a low left thoracotomy and the others via a simultaneous right thoracotomy and laparotomy. All patients had preoperative enteral or parenteral hyperalimentation. Seven patients died within 30 days after operation (operative mortality 16%). Twenty-six patients lived from 3 to 28 months postoperatively (average 11.5 months). Eleven are alive at present (average 10 months). Postoperative complications were as follows: anastomotic leak, three patients (two died); respiratory failure, four (two died); stricture, three; myocardial infarction, two (two died); cholecystitis, one; and pulmonary embolus, one (patient died). Thirty-four patients had modified fundoplication, and an inconsequential anastomotic leak developed in one. In contrast, two of the 10 patients who did not have modified fundoplication died as a result of anastomotic leak. Preoperative hospital stay ranged from 10 to 28 days (average 18); postoperative stay ranged from 10 to 40 days (average 16). Except for the three patients in whom stricture developed, all patients (92%) had continuous relief of dysphagia. We conclude that one-stage esophagogastrectomy with esophagogastrostomy is applicable in most cases and is associated with both satisfactory long-term palliation and a reasonable period of hospitalization. The addition of a modified fundoplication results in a relatively low rate of anastomotic leak.

Adenocarcinoma↗
PubMed1981

Objective evaluation of the efficacy of various venous cannulas.

Six venous cannulas (USCI No. 32, USCI No. 40, USCI No. 44, Sarns No. 40, Sarns two-stage cavoatrial, and Ferguson Argyle No. 40) were tested for efficiency of venous flow during cardiopulmonary bypass, with and without aortic cross-clamping. Each cannula was tested six times in dog models (twice in each of three dogs) and the data were averaged. The tip of the cavoatrial Sarns catheter was positioned as recommended. Two No. 32 USCI caval cannulas were placed either with or without caval snaring. The other cannulas were placed in the right atrium. Arterial flow was constant at 80 ml/kg/min, and aortic pressure averaged 84 mm Hg. Central venous pressure and the right ventricle excluded from the pulmonary artery so that blood which was not drained via the venous cannula was measured. Each single atrial cannula decompressed the right atrium (right atrial pressure 0 to 1 mm Hg) better than two caval cannulas (right atrial pressure 0 to 2 mm Hg). Caval snaring did not empty the right atrium (right atrial pressure 2 to 5 mm Hg) as well as any single cannula. The cavoatrial Sarns catheter did not empty the right atrium as well (right atrial pressure 2 to 4 mm Hg), but drained blood from the inferior vena cava (central venous pressure 0 mm Hg) better than other atrial cannulas (central venous pressure 1 to 5 mm Hg). All of the atrial cannulas performed equally well. The right ventricular vent flow varied between 63 and 70 ml/min with each of the atrial cannulas but rose to 85 ml/min with the cavoatrial Sarns catheter and 190 and 74 ml/min during caval cannulation with and without snaring, respectively. Aortic cross-clamping eliminated coronary sinus flow and decreased right ventricular vent flow. Therefore, a single atrial cannula is more efficient in draining blood from the right side of the heart than are two caval or a cavoatrial cannula. This advantage is negated by aortic cross-clamping.

Animals↗
PubMed1980

Does cardioplegic arrest compromise long-term left ventricular function?

This study was undertaken to evaluate the chronic, long-term effect of global ischemia produced by cold potassium cardioplegia during cardiopulmonary bypass. Fifteen dogs underwent either control thoracotomy and chronic instrumentation(Group A) or cardiopulmonary bypass and 60 minutes of cold cardioplegic arrest (Group B). With the dogs conscious, hemodynamic variables and left ventricular studies were recorded weekly for 12 weeks postoperatively, both at rest and during volume overload with saline solution. At rest, the heart rate in Group B was 18% higher and stroke volume was 14% lower than Group A. With volume overload, cardiac output and maximum rate of rise of left ventricular pressure in Group B rose only from 3.7 +/- 0.6 to 7.1 +/- 0.8 liters per minute and 2,410 +/- 220 to 2,730 +/- 130 mm Hg per second, respectively, compared with 3.9 +/- 0.6 to 10.4 +/- 0.8 liters per minute and 2,740 +/- 230 to 3,890 +/- 350 mm Hg, respectively, in Group A (p less than 0.01). In Group B, the other variables reached a plateau sooner than in Group A (48 versus 110 seconds). The left ventricular function curve showed a mild decrease in functional capacity and depressed contractility. Therefore, one hour of cardioplegic cardiac arrest caused no depression of function at rest. Mild depression of left ventricular function was demonstrated up to 7 weeks postoperatively during acute volume overload.

Animals↗
PubMed1979

Diagnosis and management of major tracheobronchial injuries.

From 1968 to 1978, 14 patients were treated for major tracheal or bronchial injury. Five injuries resulted from blunt trauma and nine from penetrating injury. Of the 5 patients with injury due to blunt trauma, three had avulsions of the right main bronchus from the trachea. In 2 of them, the injury was associated with stellate tears of the distal trachea and bronchus. The simple avulsion was repaired by a primary anastomosis of the right main bronchus to the distal trachea. For the other 2 patients, treatment consisted of right pneumonectomy. The remaining 2 patients in this group had complete transection of the trachea and underwent primary repair. Of the 9 patients with a penetrating injury, 4 had lacerations of the cervical trachea which were treated with neck exploration and tracheostomy. Three patients with partial transections of the cervical or upper mediastinal trachea were treated by primary closure. The other 2 patients had gunshot wounds to the distal right lateral trachea, which were treated by right thoracotomy and primary closure. There were no deaths, and the subsequent course was generally good in all patients.

Adolescent↗
PubMed1979

Effect of therapeutic-dose irradiation on left ventricular function in conscious dogs.

Every week, 8 conscious, chronically instrumented dogs underwent left ventricular (LV) function studies before, during, and after cardiac irradiation with cobalt 60 (myocardial dose of 5,000 rads at 200 rads per day through a 5 X 5 cm port). During the weekly LV function studies, left atrial pressures were raised by rapid infusion of balanced saline solution. Heart rate, aortic pressures, left and right atrial pressures, LV pressure, left ventricular end-diastolic pressure (LVEDP), and maximum rate of rise of LV pressure were recorded. Electrocardiograms were made. Cardiac outputs were obtained by thermodilution. Stroke volume, LV stroke work, and LV minute work were calculated. LV function curves were constructed each week. All dogs lost weight and became irritable after approximately 800 rads. The electrocardiograms showed signs of myocardial injury after 1,200 rads. All variables were slightly depressed during the first 8 weeks following irradiation. At the eleventh week, both left atrial pressure and LVEDP increased significantly and LV function declined. There was also clinical evidence of LV failure at rest and after volume loading. This study documents that external cardiac irradiation, in a therapeutic dose and schedule range, causes depression of LV function. These functional changes were partially reversed when the follow-up study was continued to six months after irradiation.

Animals↗
PubMed1979

Affairs of the wounded heart: penetrating cardiac wounds.

During the 10-year period ending 1 March 1978, 100 consecutive patients with penetrating cardiac wounds entered the Bexar County Hospital with some sign of life. The early and late mortality rate, 11%, declined to 8% during the last 4 years. Noncardiac injuries were responsible for six of the eleven deaths. Complications occurred in 17. The most frequently injured chambers were the right ventricle (46) and left ventricle (30). Sixty-nine patients had stab wounds and 26 had gunshot wounds. Pericardiocentesis was falsely positive or negative in 12 of 47 patients. Two distinct syndromes were apparent, hemorrhagic shock and cardiac tamponade. Patients with shock had immediate thoracotomy. Patients with suspected tamponade had a subxiphoid pericardial window, under local or light general anesthesia, for diagnosis and decompression before endotracheal intubation and sternotomy. Most wounds were repaired by direct suture. Cardiopulmonary bypass and thoracotomy before arrival in the operating room were rarely indicated.

Cardiac Tamponade↗
PubMed1979

Effects of aortic balloon pumping during cardiopulmonary bypass on myocardial perfusion, metabolism, and contractility.

This study was undertaken to determine if the production of pulsatile flow by the intra-aortic balloon pump during cardiopulmonary bypass has any beneficial effect on coronary flow, regional myocardial flow, myocardial metabolism, and left ventricular function. Thirty-six conditioned dogs were subjected to one hour of total normothermic cardiopulmonary bypass. They were divided into the following five groups: (1) controls, beating heart and femoral inflow; (2) balloon, beating heart, and femoral inflow; (3) balloon, beating heart, and aortic inflow; (4) control, fibrillating heart and femoral inflow; and (5) balloon, fibrillating heart, and femoral inflow. Total coronary flow, left ventricular flow, coronary sinus flow, and the endocardial-to-epicardial flow ratio increased in group 3. This increase in flow may have been in part due to increased resistance to flow in the descending aorta by the balloon. No differences in flow were noted in the other groups, all of which were perfused via the femoral artery. No significant differences in myocardial metabolism or left ventricular contractility could be demonstrated between balloon-treated and control groups in these normal hearts.

Adenosine Triphosphate↗
PubMed1979

Lung bacterial clearance following pulmonary contusion.

Bacterial infections frequently,complicate pulmonary contusion and are the leading cause of death in such patients. This study evaluated the effects of pulmonary contusion alone and contusion associated with other factors on the ability to clear aerosolized bacteria from the lung. Lung bacterial clearance of Staphylococcus aureus and Klebsiella pneumoniae was studied in animals with isolated pulmonary contusion, or contusion associated with blood loss, rapid crystalloid infusion, or steroid administration. An isolated pulmonary contusion produced no impairment of the ability of the contused lung to clear either gram-negative or gram-positive organisms. The addition of acute blood loss and crystalloid infusion resulted in decreased clearance from the contused lung; steroid administration caused a marked depression in lung bacterial clearance from the noninjured lung as well. The canine model described allowed for study of regional differences in bacterial clearance. The data presented support several conclusions; (1) the contused lung is not more susceptible to bacterial infection than the normal lung: (2) acute blood loss renders the contused lung less able to clear bacteria; (3) crystalloid infusion markedly depresses lung bacterial clearance; and (4) steroids have a deleterious antibacterial effect on both contused and noncontused lungs.

Aerosols↗
PubMed1979

Effects of systemic hypothermia on myocardial metabolism and coronary blood flow in the fibrillating heart.

Ventricular fibrillation during normothermic cardiopulmonary bypass is deleterious to the myocardium. This study was undertaken to determine if moderate systemic hypothermia would protect the myocardium during ventricular fibrillation. Fourteen mongrel dogs were subjected to 1 hour, 15 minutes of total cardiopulmonary bypass. Ventricular fibrillation was induced by a continuous electrical alternating current applied at the beginning of bypass and lasting for 1 hour. Six animals were maintained at normothermia (Group I), and eight were cooled to 30 degrees C. for 1 hour (Group II). The hypothermic group (Group II) demonstrated lower myocardial oxygen consumption and metabolism, decreased coronary blood flow, and less myocardial lactate production during ventricular fibrillation than did Group I. It is concluded that hypothermia does offer some protection, although not complete, against the deleterious effects of ventricular fibrillation described previously.

Adenosine Triphosphate↗