Letter: The "thumb sign" and "little finger sign" in acute epiglottitis.
Explore the source record for details and available documents.
Acute Disease↗
Biomedical subjects
J K Podgore
Publications and source records attributed to J K Podgore.
Letter: Immunopotentiation by levamisol.
Explore the source record for details and available documents.
Animals↗
Letter: Techniques for recovery of B. pertussis on culture.
Explore the source record for details and available documents.
Bacteriological Techniques↗
Enhanced host defense mechanisms with levamisole in suckling rats.
Levamisole, a synthetically produced anthelminthic agent, was administered to suckling rats that were challenged with bacterial and viral pathogens. There was no in vitro antibacterial or antiviral effect of the drug. However, enhanced survival was demonstrated in those animals treated with levamisole and challenged with Staphylococcus aureus or herpes simplex virus. The mechanism for protection against the bacteria appears to be enhancement of the primary inflammatory response. The mechanism for protection against herpes simplex virus is not yet understood.
Animals↗
Enhancement of host defense mechanisms against gram-positive pyogenic coccal infections with levo-tetramisole (levamisole) in neonatal rats.
Explore the source record for details and available documents.
Animals↗
The rapid diagnosis of infectious mononucleosis using an ELISA that detects IgM antibody to a peptide component of Epstein-Barr virus nuclear antigen.
An enzyme-linked immunosorbent assay (ELISA) that detects IgM antibody to a peptide component of the Epstein-Barr virus (EBV) nuclear antigen (EBNA-1) was compared with a conventional rapid heterophil antibody method for the rapid diagnosis of infectious mononucleosis. Discrepancies between the two methods were further analyzed using an indirect immunofluorescence assay to detect antibodies to EBV antigens. We evaluated 298 cases of suspected infectious mononucleosis. The ELISA was very sensitive (98.7%) and able to detect some cases (seven (9%) of 75 confirmed positives) that were negative by the rapid heterophil antibody test, but confirmed by immunofluorescence. However, approximately 17% of all positive tests could not be confirmed by EBV-specific immunofluorescence; thus, the overall positive predictive value was 83%; negative predictive value was 99.5%; and specificity was 93%. The high rate of false-positive tests makes this rapid ELISA unsuitable for the diagnosis of infectious mononucleosis.
Adolescent↗