Search PubMed⌕ Search

Biomedical subjects

J K Behrens

Publications and source records attributed to J K Behrens.

7 recordsLinked to original sources

[Treatment of cancer pain with continuous opioid via spinal catheters].

Continuous intrathecal morphine treatment of cancer pain is reviewed on the basis of a literature search. Clinical, pharmacological and technical aspects are described, and the indications and potential complications are discussed. Three case histories illustrate the practical conduct and problems. The authors conclude that continuous intrathecal morphine treatment offers significant therapeutical advantages, when pain relief is not provided by conventional methods.

Analgesia, Patient-Controlled↗

Quantitative assessment of corneal astigmatic surgery: expanding the polar values concept.

The purpose of astigmatic corneal surgery is to flatten the steeper meridian of the preoperative cylinder, to steepen the flatter meridian, or both. Therefore, it may be useful to quantitate the surgical effect by calculating the equivalent dioptric value of the postoperative cylinder in these principal meridians. In this study, the dioptric value projected on the preoperatively steeper meridian is termed the with-the-power (WTP) component, the portion projected on the flatter meridian, the against-the-power (ATP) component. Consider a preoperative net astigmatism of the power N in the meridian a. After astigmatic corneal surgery, the postoperative corneal cylinder is M in the meridian b. For the postoperative cylinder, the WTP component = M x sin2([b + 90]-a). The ATP component = M x cos2([b + 90]-a). The astigmatic polar value is defined as the difference between these magnitudes: AKP = M x (sin2[(b + 90)-a] - cos2[(b + 90)-a]). By calculating the astigmatic polar value, the surgeon immediately knows the outcome of the surgical procedure (i.e., whether the preoperative astigmatism has been undercorrected, overcorrected, or perfectly corrected). We describe the theory behind this new formula and discuss its applications and limitations.

Astigmatism↗

ACE inhibitor premedication attenuates sympathetic responses during surgery.

We studied cardiovascular and catecholamine responses for 3 days in three groups of patients undergoing abdominal hysterectomy. The night before surgery and again 2 h before induction of anaesthesia, patients received the ACE inhibitor, ramipril, the beta 1 blocker, metoprolol, or placebo. In the actively treated groups, mean diastolic pressure was reduced during surgery and increases in heart rate and arterial pressure after surgical incision were attenuated. During operation, stroke volume (SV) and cardiac output (CO) were significantly higher in the ramipril group. In contrast, beta 1, adrenergic block caused no significant changes in SV or CO. The concentration of noradrenaline in plasma and urine indicated that ACE inhibition caused attenuated release of noradrenaline. The results support the concept that angiotensin II facilitates release of noradrenaline from sympathetic nerves and that ACE inhibition inhibits this release.

Adult↗

Calcium acetate versus calcium carbonate as phosphorus binders in patients on chronic haemodialysis: a controlled study.

The first reported double-blind cross-over comparison between the phosphorus binders calcium carbonate and calcium acetate was undertaken in 15 stable patients on chronic maintenance haemodialysis. Detailed registration of diet and analysis of the protein catabolic rate suggested an unchanged phosphorus intake during the study. It was found that predialytic serum phosphate concentration was significantly decreased by 0.11 mmol/l (0.34 mg/dl) (P = 0.021, 95% confidence limits 0.02-0.21 mmol/l; 0.06-0.65 mg/dl) during calcium acetate treatment. The calcium phosphate product was insignificantly decreased during treatment with calcium acetate whereas we could not exclude the possibility that calcium concentration had increased.

Acetates↗

The influence of a solid and liquid bolus on food-stimulated gastroesophageal reflux.

Using a radiological method to demonstrate food-stimulated gastroesophageal reflux (GER), a comparative study was carried out employing a solid, already validated bolus versus a liquid one. One hundred and four consecutive patients received both a solid and a liquid bolus in randomized order. GER was observed in 37 (35.6%) patients receiving the solid bolus versus 28 (26.9%) with the liquid one. This means that the solid bolus provokes significantly more reflux (P less than 0.02). GER, grade II (reflux above the level of the carina), occurred equally often as a result of both types of bolus, however. The study suggests that significant, food-stimulated GER is independent of the consistency of the foodstuffs and may be detected employing a liquid bolus. This result might be used in the examination of infants for GER, using milk as a food stimulus.

Adult↗

Correlation between polar values and vector analysis.

PURPOSE: To evaluate the possible correlation between polar value and vector analysis assessment of surgically induced astigmatism. SETTING: Department of Ophthalmology, Aalborg Sygehus Syd, Denmark. METHODS: The correlation between polar values and vector analysis was evaluated by simple mathematical and optical methods using accepted principles of trigonometry and first-order optics. RESULTS: Vector analysis and polar values report different aspects of surgically induced astigmatism. Vector analysis describes the total astigmatic change, characterized by both astigmatic magnitude and direction, while the polar value method produces a single, reduced figure that reports flattening or steepening in preselected directions, usually the plane of the surgical meridian. There is a simple Pythagorean correlation between vector analysis and two polar values separated by an arch of 45 degrees. CONCLUSION: The polar value calculated in the surgical meridian indicates the power or the efficacy of the surgical procedure. The polar value calculated in a plane inclined 45 degrees to the surgical meridian indicates the degree of cylinder rotation induced by surgery. These two polar values can be used to obtain other relevant data such as magnitude, direction, and sphere of an induced cylinder. Consistent use of these methods will enable surgeons to control and in many cases reduce preoperative astigmatism.

Astigmatism↗