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Biomedical subjects

J Juskowa

Publications and source records attributed to J Juskowa.

At least 37 records · Page 2Linked to original sources
PubMed1978

Study of antibody dependent cellular cytotoxicity (ADCC). III. Preliminary findings concerning the influence of immunosuppressive drugs.

The present studies were undertaken to characterize cytotoxic activity of lymphocyte-(ADCC) in the course of primary glomerulonephritis and to evaluate the influence of some of the immunosuppressive drugs on lymphocytes of examined patients. 18 patients were studied; 12 of them were treated by combined therapy with prednisone, azathioprine and chlorambucil. Results were analyzed on the basis of healthy individuals ADCC activity. In the 11 treated patients significant decrease of ADCC activity was observed while non-treated group exhibited as high activity as healthy individuals. Which of given drugs is responsible for the decreased ADCC activity, remains questionable and is currently under the study.

Adult↗
PubMedDate not supplied

Physical rehabilitation and risk of atherosclerosis after successful kidney transplantation.

Regular physical activity is usually associated with significant health benefits, but therapeutic exercise is seldom routine in renal transplant recipients. We report a randomized clinical trial of exercise training after renal transplantation. Sixty-nine patients were randomly recruited on the first or second day after kidney transplantation into two groups: exercise intervention (PT) and standard care (CT) as controls. The exercise training program consisted of tailored exercises to be performed under a physiotherapist's supervision for 15 to 30 minutes every second hospital day. At that time, biochemical markers of graft function were assessed including specific tests for atherosclerosis. Repeated measures analysis of variance was performed to determine differences between the two groups. We found an inverse correlation between total homocysteine as well as interleukin-18 (IL:18) levels and muscle strength of the upper limbs (r = -.78, P < .0001). There was a positive correlation between muscle strength and improved graft function in the PT group versus CT groups (r = .05; P < .05). Hyperhomocysteinemia and high IL-18 expression in renal allograft recipients may be independent markers of early atherosclerosis development.

Adult↗