Search PubMed⌕ Search

Biomedical subjects

J Jovanovic

Publications and source records attributed to J Jovanovic.

8 recordsLinked to original sources
PubMed2006

Molecular and phenotypic characteristics of patients with phenylketonuria in Serbia and Montenegro.

Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism in Caucasians. PKU is caused by mutations in the gene encoding phenylalanine hydroxylase (PAH) enzyme. Here, we report the spectrum and the frequency of mutations in the PAH gene and discuss genotype-phenotype correlation in 34 unrelated patients with PKU from Serbia and Montenegro. Using both polymerase chain reaction-restriction fragment length polymorphism and 'broad-range' denaturing-gradient gel electrophoresis/DNA sequencing analysis, 19 disease-causing mutations were identified, corresponding to mutation detection rate of 97%. The most frequent ones were L48S (21%), R408W (18%), P281L (9%), E390G (7%) and R261Q (6%), accounting for 60% of all mutant alleles. The genotype-phenotype correlation was studied in homozygous and functionally hemizygous patients. We found that the most frequent mutation, L48S, was exclusively associated with the classical (severe) PKU phenotype. The mutation E390G gave rise to mild PKU. For the mutation R261Q, patients had been recorded in two phenotype categories. Considering allele frequencies, PKU in Serbia and Montenegro is heterogeneous, reflecting numerous migrations over the Balkan Peninsula.

Genotype↗
PubMed2004

The influence of hydroxyapatite modification on the cross-linking of polydimethylsiloxane/HAp composites.

Hydroxyapatite (HAp) was modified by the action of various hydrophobic agents based on silicon-containing compounds. The influence of the type of applied agent on the thermodynamic and kinetic parameters of the cross-linking of poly(dimethyl siloxane)/HAp composites was investigated. All the modified HAp particles became hydrophobic and these samples were used to synthesize the polysiloxane/hydroxyapatite composites (PDMS/HAp). The possible modes of interaction between the hydroxyapatite and hydrophobing agents were discussed. The most probable interaction between hydroxyapatite and the applied hydrophobing agents is hydrogen bonding. PDMS/HAp composites were formed directly in the cell of the DSC and cross-linking was investigated in situ. It was determined that the introduction of hydroxyapatite into polysiloxane matrices changed the enthalpy of cross-linking, as well as the activation energy of cross-linking and reaction order, while the introduction of modified HAp led to thermodynamic and kinetic parameters more similar to those of the cross-linking of unfilled elastomer.

Biocompatible Materials↗
PubMed2004

Suicide in the elderly 60 years of age and over in the south-east part of Serbia.

Some previous investigations indicated that economic crisis (inflation in Serbia 1993/94) have great influence on increasing suicide rates in Serbia. After that suicide decreased, despite the war and bombing in 1999, specially among the elderly people. A total of 453 suicides were registered on the territory of south-eastern Serbia during 1995-2001 years. Of them 295 (65.1%) were aged over 60 years. Generally linear trends of suicide among both genders from 1995 to 2001 decreased, but the slope of decreasing was grater among males than among females. The highest rates among the both genders were registered in the years with the maximum number of suicides, but the linear trends of rates have statistically important correlation with time (r>0.5). Average annual suicide rate among males was 42.5, and among women it was 18.7. The highest average annual suicide rate among men was observed in the age group 75 years and over (93.3), and the lowest in the age group 65-69 (20.6). Among males, in the all age group linear trends of suicide rates decreased, with the highest slope among 75 years and over and the lowest among 65-69 years. The highest suicide rate among females was registered in age group 75 years and over (25.6), the lowest in the age group 65-69 (13.5). The linear trends are similar as among males: downward trend was observed among all aged groups, with the highest slope among women 75 years and over. The most common way of suicide among men was hanging up (63%), poisoning and by firearms. There were no statistical differences between way of suicide and age groups. The most frequent way of suicide among females was hanging up (55%), poisoning (25%) and drowning (12%). There were statistically significant differences in drowning between age groups, 70-74 and 75 and over (p<0.05), and between poisoning and age groups 60-64 years and 75 years and over. Poisoning and drowning are statistically more frequent among women than among men.

Age Distribution↗
PubMed1989

Objective and subjective attractiveness and early adolescent adjustment.

Using data from the Pennsylvania Early Adolescent Transitions Study (PEATS), this study assessed how objective physical attractiveness (PA), indexed by appraisals from others, and subjective PA, indexed by self-appraisals, relate to each other and, in turn, to early adolescent adjustment (indexed by self-esteem and anxiety). Findings indicated a low relationship between objective and subjective PA. Only subjective PA was associated with adjustment.

Adaptation, Psychological↗
PubMed1979

[Not Available].

Explore the source record for details and available documents.

History, Modern 1601-↗
PubMedDate not supplied

[Results of medical selection of drivers and candidates for drivers of motor vehicles].

The aim of this study is the analysis of medical selection of drivers and candidates for car drivers. The examination included 41,561 drivers (36,008 candidates for car drivers sent to preliminary medical examination, 5,175 professional drivers sent to periodic medical examination and 378 drivers sent to special medical examination). At the preliminary medical examination, 1.5% of candidates for car drivers were declared to be incapable of driving and 8.4% of candidates had a limited driving ability. At the periodic medical examination, 8.2% of drivers were declared to be incapable to driving and 26% of drivers had a limited driving ability. At the special medical examination, 34.9% of drivers were declared to be incapable for driving and 54.3% of drivers had a limited driving ability. The reasons for driving incapability and for limited driving ability were the disturbances of psychologic-psychiatric and neurologic state, cardiovascular diseases, endocrine diseases and sight disturbances. In our opinion, medical selection of drivers and candidates for car drivers is a significant preventive measure of traffic trauma. New, more subtle methods for determination of the latent disturbances must be developed. Periodic medical examination for amateurs in the period between the preliminary medical examination and 65 years of age must biobligatory.

Automobile Driving↗
PubMedDate not supplied

[Work capacity evaluation in workers with arterial hypertension].

The aim of this study was to show the results of working ability estimation of the workers with arterial hypertension. The estimation included 313 workers with arterial hypertension estimated by Disability Commission during 1999. Arterial hypertension was a leading diagnosis in 30.9% cause of working ability estimation. The majority of workers belonged to the 41-60 years age group and were with arterial hypertension with complications on the fundus and on the heart. In the examined group the majority of workers was declared as first category invalid (35.8%), while 32.3% of hypertensive workers had to change the working place. The majority of the first category invalids were among the hypertensive workers from textile and chemical industry, as well as among the professional drivers. The changing of the working place was more frequently suggested to the workers in textile and metal industry and in printing firms. These results could be explained by the influence of professional noxious agents on the onset and development of arterial hypertension.

Adult↗