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Biomedical subjects

J Jouquan

Publications and source records attributed to J Jouquan.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Binding of complement by anti-native desoxyribonucleic acid antibodies in systemic lupus erythematosus].

Antibodies directed against double-stranded (native) desoxyribonucleic acid (dsDNA) were detected by the immunofluorescence technique on Crithidia luciliae in 38 out of 58 patients with systemic lupus erythematosus (SLE) and in 22 out of 296 controls with autoimmune diseases. The SLE patients had high titers of anti-dsDNA antibodies which belonged at least to the IgG class and fixed the complement in 20 out of 38 cases. These complement-fixing antibodies differed from the others in their greater activity, as evaluated by C3 levels, and in their association with a high incidence of renal lesions.

Adolescent↗
PubMed1985

Nonorgan-specific autoantibodies and immunoglobulin allotypes in relatives of patients with monoclonal gammopathy.

Polyclonal immunoglobulin increase, rheumatoid factor, antinuclear antibodies and cold lymphocytotoxins were detected 10, 8, 7 and 8 times, respectively, in a group of these informative families (22, 17 and 29 subjects tested, respectively). Each family included at least 1 subject with a monoclonal gammopathy in addition to that of the proband. No correlation could be shown between any of these abnormalities and Gm haplotypes. Nonetheless, it is worth noting that 6 out of 41 relatives under 30 years of age had cold lymphocytotoxins.

Adolescent↗
PubMed1985

[Pure hypertensive nephropathy associated with malignant arterial hypertension in disseminated lupus erythematosus. Case with a favorable outcome].

The authors report the association of a clinically florid form of lupus with malignant hypertension and renal failure. The renal histology revealed lesions of nephroangiosclerosis, with virtually no signs of lupus proliferative glomerulonephritis. With a follow-up period of 42 months, the renal function has returned to normal, although steroid treatment has been interrupted for 33 months. However, intensive antihypertensive treatment is still required. This unusual case is discussed in the light of previous reports in the literature of the association of disseminated lupus erythematosus and malignant hypertension, which is nevertheless a rare entity.

Adolescent↗
PubMed1984

[Yersinia enterocolitica septicemia occurring in a hospital milieu. A case with septic shock in an immunocompromised patient].

A case of Yersinia enterocolitica septicemia is reported. This case is unusual as the infection was apparently acquired within the hospital and septic shock occurred during the course. Immunodeficiency, which is nearly consistent in similar observations and was established in the index case, was apparently caused by protein-calorie deficiency, without any of the usual associations reported in the literature.

Aged↗
PubMed1984

[Gougerot-Sjögren syndrome and monoclonal immunoglobulin].

Serum electrophoresis and immunoelectrophoresis were performed in 67 patients with Sjögren's syndrome. We found a monoclonal gammapathy in 11 cases: IgG (10 cases) and IgM (1 case). 1 monoclonal gammapathy was detected in 2 of 21 patients with primary Sjögren's syndrome. All patients with monoclonal gammapathy were asymptomatic.

Adult↗
PubMed1984

Genetic variants of serum alpha-1-antitrypsin (Pi types) in a Breton population, the Bigoudens.

Pi typing was carried out by high resolution isoelectric focusing in 397 Bigoudens and in 100 non-Bigouden Bretons. Gene frequencies were computed by the gene counting method. No difference between the two groups could be demonstrated, neither was there a deviation from the expected Hardy-Weinberg distribution nor a heterogeneity between the Bigouden villages. The results were significantly different (p less than 0.02) from those reported in Normans.

Ethnicity↗
PubMed1984

[Serum immunoglobulins and complement fractions in protein malnutrition].

Serum immunoglobulins and some complement components (C1q, C3c, C4, factor B, C9) have been evaluated in 99 malnourished patients. The sole abnormality which seems related to protein calorie malnutrition is a C1q decrease significantly correlated to serum albumin, thyroxin binding prealbumin and retinol binding protein. The immunoglobulins modifications seem to be related to pathological conditions associated with malnutrition (sepsis, liver diseases).

Adult↗
PubMed1984

[Early cerebral vascular accidents in treated Horton's disease. Responsibility of the corticoid treatment?].

Two cases of strokes in the vertebrobasilar territory were observed in patients with Horton's disease during the first week of treatment when the inflammatory process seemed clinically and biologically under control. The mechanisms of arterial ischaemia are discussed: specific localisation of giant cell arteritis, associated atherosclerosis, failure of therapy or a possible inducing role of steroid therapy as the chronology of these cases would suggest.

Adrenal Cortex Hormones↗
PubMed1984

[Estrogen-progestogen agents and megaloblastic anemia].

TwO cases of megaloblastic anaemia, of which one was very severe, occurring in women who had been taking oestrogen-progestogen oral contraception over a long period of time, are reported. The authors take the opportunity, after having reviewed the literature, of pointing out the role of oestro-progestogen products in bringing about vitamin deficiencies. They discuss how and where oestrogen-progestogen products work on folic metabolism and emphasize that there is an associated factor which starts off the deficiencies.

Adult↗