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Biomedical subjects

J Jos

Publications and source records attributed to J Jos.

58 records · Page 4Linked to original sources
PubMedDate not supplied

[Measure of glycosylated hemoglobin A1c: its value in the control of juvenile insulin-dependent diabetes (author's transl)].

HbA1c percentage was determined in 82 insulin-dependent juvenile diabetic patients. The concentration of HbA1c reflects the level of chronic hyperglycaemia during the preceding 4 to 8 weeks and appears to correlate closely with the commonly used methods for monitoring diabetic control. HbA1c measurement provides a reliable and objective test for periodic assessment of insulin-dependent juvenile diabetes. It may serve as a valuable tool for determining the level of metabolic control in each patient and measuring the effectiveness of various therapeutic regimens.

Adolescent↗
PubMedDate not supplied

[Electrolyte balance in a case of congenital chloride diarrhea].

A case of congenital chloride diarrhoea with metabolic alkalosis is reported in a 9-year-old boy who has intractable chronic diarrhoea with large watery stools from birth. Balance studies confirm the high fecal loss of chloride and the close relationship between chloride intake and fecal losses of electrolytes.

Alkalosis↗
PubMedDate not supplied

Insulin resistance and excess weight in adolescent insulin-dependent diabetic girls.

Insulin dependent diabetic adolescent girls show a tendency towards excess weight. The relationship between insulin resistance and body mass index (BMI) was investigated in 23 Type 1 adolescents aged 13-20 yr. These patients body mass indexes spanned from 19.8 to 30.5. Excess weight was evaluated using Z-scores, corrected for age with reference to french standards. 9 patients with a Z-score greater than 2 were considered as obese. Insulin sensibility was measured using the hyperinsulinaemic euglycaemic clamp (insulin infusion rate, 1 mU kg-1 min-1). The mean glucose infusion rate during the clamp was low in the diabetic girls (2.29 +/- 1.35 mg kg-1 min-1), confirming the existence of insulin resistance. However, the degree of insulin resistance was not correlated with the excess in weight (glucose infusion rate, 2.23 +/- 1.24 vs 2.33 +/- 1.46 mg kg-1 min-1 in the obese and the non-obese patients, respectively). None of the factors which influence on insulin sensitivity could explain this lack of correlation, the obese patients showing greater daily insulin doses (1.36 +/- 0.22 vs 1.22 +/- 0.25 unit kg-1 day-1) and worse metabolic control (Hba1C, 10.9 +/- 1.4 vs 10.2 +/- 2.0%). Insulin resistance was significantly correlated with free fatty acid levels during the clamp.

Adolescent↗