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J Jones

Publications and source records attributed to J Jones.

At least 595 records · Page 33Linked to original sources
PubMed1988

Physiological growth hormone (GH) secretion during the recovery from psychosocial dwarfism: a case report.

We describe a 6.4 year old boy who had reversible GH insufficiency secondary to psychosocial dwarfism. On removal to a more favourable environment we observed the recovery of physiological GH secretion by progressive increase in GH pulse amplitude. These observations are relevant to our understanding of the control of GH secretion in that GH pulse frequency appears invariable and alteration in GH secretion is by pulse amplitude modulation.

Child↗
PubMed1988

What are the ultrasound and biochemical features of impending ovulation?

Thirty-two ovulatory women had serial ultrasound measurements of uterine volume, endometrial thickness and leading follicular diameter compared with serum oestradiol, testosterone and sex-hormone binding globulin. Follicular diameter, endometrial thickness and uterine volume were significantly correlated with serum oestradiol. The day before ovulation was characterized by maximal values for oestradiol, testosterone, luteinizing hormone, endometrial thickness, uterine volume and leading follicular diameter. Leading follicular diameter and endometrial thickness in particular, appear to be useful parameters to indicate impending ovulation.

Endometrium↗
PubMed1988

Growth and endocrine function after renal transplantation.

Longitudinal height data and physical development were assessed in 45 boys and 34 girls after renal transplantation. All children received alternate day steroids and either azathioprine or cyclosporin A for immunosuppression. There was a significant increase in growth velocity after transplantation in prepubertal children. Growth velocity declined at the expected age of the normal pubertal growth spurt, however, with delay in the appearance of secondary sexual characteristics. Overnight hormone profiles in 17 adolescent subjects with short stature or maturational delay, or both, showed blunting of growth hormone and gonadotrophin pulsatility. It is likely that long term steroid treatment after renal transplantation induces the clinical and endocrine picture of delayed puberty. Failure of growth to accelerate at this time is a cause of short stature, which may have an effect on adult height.

Adolescent↗
PubMed1988

Growth and endocrine function in steroid sensitive nephrotic syndrome.

Longitudinal height data and physical development were assessed in 29 boys and 12 girls taking long term steroid treatment for steroid sensitive nephrotic syndrome. Growth in both boys and girls, assessed by changes in height standard deviation score (delta Ht SDS), worsened significantly with chronological age. There was a significant negative correlation between delta Ht SDS and duration of treatment in boys, but not in girls. There was no correlation between delta Ht SDS and relapse rate or the use of cyclophosphamide. In the boys, Ht SDS decreased significantly only after the age of 10 years and was associated with delay in the appearance of secondary sexual characteristics. Eight adolescent boys were assessed endocrinologically by an overnight hormone profile. Blunting of the pulsatility of growth hormone and gonadotrophins was seen in six. Normal profiles were seen in two subjects who were both off steroid treatment at the time of study. Abnormal endocrine function in adolescent boys treated long term for steroid sensitive nephrotic syndrome corresponded with the clinical picture of delayed onset of puberty, which accounted for severe growth retardation in a substantial proportion of subjects.

Adolescent↗
PubMed1988

Physiological growth hormone secretion in children with short stature and intra-uterine growth retardation.

31 prepubertal children with short stature [mean height standard deviation score (SDS) -2.84] and low birth weight (mean -2.82 SDS) were studied. Mean age was 6.0 years and mean height velocity SDS was -0.76. Patients were classified as having either the clinical characteristics of Russell-Silver syndrome (RSS) (4 F, 13 M) or not (4 F, 10 M). All children had an overnight profile of spontaneous growth hormone (GH) secretion. 4 children achieved a maximum GH concentration of less than 20 mU/l. 9 children with RSS secreted only one large GH peak during the night. Most of the non-RSS group had normal GH pulse frequency but 3 boys had a fast-frequency pattern. Abnormal GH secretion may contribute towards growth failure in children with low birth weight/RSS.

Body Height↗
PubMed1988

Elevated free androgen index as an indicator of polycystic ovaries in oligomenorrhoea without obesity or hirsuties.

A group of oligomenorrhoeic women without obesity or hirsuties was investigated with high-resolution ultrasound, laparoscopy and biochemical parameters. In this series, polycystic ovaries (PCO), as defined by ultrasound and laparoscopy, are a common cause of oligomenorrhoea in women without the classic symptoms, and were strongly associated with an elevated free androgen index (FAI). Despite an elevated FAI, these women were not hirsute, It would seem reasonable to include a FAI in the investigation of the oligomenorrhoeic woman, along with the more 'standard' tests, such as thyroid function and a prolactin level.

Adult↗
PubMed1988

Factors influencing the free androgen index in a group of subfertile women with normal ovaries.

Eighty-five regularly cycling women with normal ovaries at laparoscopy, were studied to determine the factors that influence the free androgen index (FAI). It was found that body mass index (BMI), age of the patient and the phase of the menstrual cycle that the blood was collected can all affect the FAI. It is recommended that where possible, specimens should be collected in the early follicular phase to avoid misinterpretation of the result.

Age Factors↗
PubMed1988

Resumption of puberty after long term luteinizing hormone-releasing hormone agonist treatment of central precocious puberty.

To determine whether puberty resumes normally after long term LHRH agonist (LHRHa) treatment, we studied 16 children with central precocious puberty treated with LHRHa (D-Trp6,Pro9,NEt-LHRH) for 1-4 yr (mean, 3.3 yr). Treatment was discontinued at a mean age of 11.6 +/- 1.3 (+/- SD) yr. Plasma hormone levels, growth velocity, rate of bone maturation, and pubertal stage were assessed at the end of treatment and 3 and 12 months later. Basal plasma sex steroid and basal and LHRH-stimulated gonadotropin levels returned to near-pretreatment levels 3 months after discontinuation of therapy and were fully restored to pretreatment levels at 12 months. Growth velocity, which had been 7.8 cm/yr before treatment, was stable after discontinuation of treatment at approximately 2.6 cm/yr. The predicted height, which had increased during treatment (P less than 0.01), remained stable at approximately 5 cm above the pretreatment predicted height. The rate of bone age advancement (delta bone age/delta chronological age) increased gradually from 0.4 at the end of treatment to the normal value of 0.9 12 months posttreatment. Breast and pubic hair pubertal stages, which were stable throughout treatment and were 4.0 +/- 0.8 (+/- SD) and 3.6 +/- 1.0 at the end of treatment, increased to 4.9 +/- 0.2 and 4.5 +/- 1.0. This approximated the normal rate of 1 stage/yr. Menses occurred in 8 of 12 girls within 1 yr after treatment and in an additional 3 by 20 months after treatment. Six of the girls had menstruated before treatment, and all of these menstruated within 14 months after discontinuing therapy. We conclude that gonadotropin and sex steroid secretion and the clinical progression through puberty appear to resume normally after discontinuation of long term LHRHa treatment of central precocious puberty. Long term follow-up will be required, however, to determine whether the improvement in predicted height of these patients will be achieved, and whether adult reproductive function will be normal.

Body Height↗
PubMed1988

Refractory periodontitis: mixed infection with Bacteroides gingivalis and other unusual Bacteroides species. A case report.

Host immune response and the predominant subgingival microflora were evaluated in a 47-year-old male exhibiting severe, recurrent periodontitis. The patient's neutrophils were chemotactically elevated but other functions were within normal limits. Significantly, Bacteroides gingivalis and Bacteroides zoogleoformans constituted 80% of the cultivable microflora and total cell count in subgingival plaque. The remainder of the cultivable microbiota was comprised of Fusobacterium nucleatum and Haemophillis aprophillis. The present study provides additional evidence for an association between B. gingivalis and severe, recurrent periodontal disease.

Bacteroides↗
PubMed1988

The appointed day.

Explore the source record for details and available documents.

Community Health Nursing↗
PubMed1988

School health education to prevent the spread of AIDS: overview of a national programme.

The ultimate goal of CDC's School Health Education to Prevent the Spread of AIDS programme is to reduce the incidence of HIV infection among school-aged youth. Working objectives that integrate programme research and development activities are listed in the opposite Table. In 1982 it was estimated that of the 4.6 billion people in the world, about one billion were school-aged, and about 870 million of these youth were enrolled in schools. WHO, UNESCO, and the International Union for Health Education have recognized that schools could provide a critical means for ensuring that young people throughout the world understand the global AIDS pandemic they face, and what they can do to protect themselves, the families for which they will become responsible, and the communities in which they will reside. But if schools are to provide effective AIDS education, they will require the commitment and active collaboration of education and health leaders in local, national, and international agencies.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Quantitative analysis of the tomographic thallium-201 myocardial bullseye display: critical role of correcting for patient motion.

Single photon emission computed tomography (SPECT) myocardial 201TI imaging appears to offer major improvements over planar imaging. Quantitative analysis of the 201TI images appears to offer major advantages over subjective analysis in planar imaging, but the three-dimensional data available in SPECT images requires special approaches to analysis and display. Thus the myocardial "bullseye" display was developed to summarize and analyze the three-dimensional images of the left ventricle in two dimensions. The relative 201TI distribution to each region of the left ventricle of an individual patient can be displayed as the number of s.d.s away from normal that the region falls. We found that patient motion during the 22 min required for SPECT imaging appeared to produce artifactual defects. Thus, computer programs were developed to quantitate motion between consecutive frames of a [201TI] SPECT myocardial imaging study, simulate nonreturning vertical motion in normal patients, and correct the acquired data for motion. Motion as small as 0.5-1.0 pixel (3-6 mm) in the vertical (axial) direction caused artifactual defects in the quantitative bullseye display that resulted in a false-positive rate of up to 40% for a +1.0 pixel shift. Patient motion of magnitude greater than the threshold value for artifact-production (0.5 pixel) occurred at a rate of 10%, and should be corrected before tomographic reconstruction.

Heart↗