Biomedical subjects

J Joncas

Publications and source records attributed to J Joncas.

38 records · Page 3Linked to original sources

PubMed1966

Studies on infectious mononucleosis. II. Attempts at experimental transmission to monkeys.

Heparinized blood specimens obtained from two patients in the acute phase of infectious mononucleosis and from a healthy technician were injected intravenously into rhesus monkeys (Macaca mulatta) and the animals were observed for three weeks to one month for clinical, hematological and serological signs of infectious mononucleosis.Splenomegaly was the only definite clinical finding after 12 and 16 days, respectively. There were no definite hematological changes.At autopsy, hyperplasia of the germinal centres of lymphoid follicles, occasional foci of lymphocytic infiltration in the red pulp, and abnormal lymphoid cells in venules or arteries of the spleen were noted.The lesions in the spleen suggest that asymptomatic, presumably viral, infections occur in rhesus monkeys after inoculation with material from patients with infectious mononucleosis.

Adolescent↗

PubMed1966

Studies on infectious mononucleosis: I. Cytopathic agents and immunofluorescence studies.

Viral studies were carried out on throat swabs, rectal swabs and washed white blood cells from 27 cases of infectious mononucleosis (positive Paul-Bunnell-David-sohn test), and from 22 controls.Four cytopathic agents were isolated in the test group, two of which were readily subcultured for at least three successive passages.Three cytopathic agents were recovered in the control group, two of which have been identified as adenovirus type 5 and adenovirus type 3. The unidentified agents tested so far are sensitive to ether and to pH 3. The results of acridine-orange staining and the immunofluorescence technique, using a conjugated control serum and two conjugated convalescent infectious mononucleosis sera, indicate that the isolated agent or agents in the test group are RNA-type agents with a cytoplasmic cycle of development. The overall results of this study lead the authors to suspect a respiratory syncytial-like myxovirus as the as yet unidentified agent which they recovered.

Adenoviridae↗