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Biomedical subjects

J Jiang

Publications and source records attributed to J Jiang.

At least 451 records · Page 25Linked to original sources
PubMed1991

[Effect of electrical stimulation and lesion of N reticularis paragigantocellularis lateralis on acupuncture analgesia in rats].

The present study was aimed to investigate the role of the reticularis paragigantocellularis lateralis (RPGL) in acupuncture analgesia. Tail-flick response to electrical stimulation of the tail skin was taken as index of pain response. The first part of the study consisted of four groups: (1) surgical control, (2) electro-acupuncture, (3) electrical stimulation of RPGL, and (4) stimulation of RPGL simultaneously with electro-acupuncture. The pain threshold in the first group was quite stable during the experiments, but increased significantly after electro-acupuncture and/or brain stimulation (n = 14, P less than 0.01; n = 8, P less than 0.001; n = 14, P less than 0.001). The pain threshold of the fourth group increased much more than the second and the third group (P less than 0.001, P less than 0.01). In the second part of the study, the effect of electro-acupuncture was reduced significantly after electrical lesion of the RPGL unilaterally (n = 12, P less than 0.01). The present work indicates that electrical stimulation of RPGL enhances electro-acupuncture analgesia, whereas the lesion of RPGL reduces it. It is suggested that RPGL plays a role in acupuncture analgesia.

Acupuncture Analgesia↗
PubMed1990

[Effects of promethazine on acupuncture analgesia].

Promethazine, one of histaminergic H1-receptor antagonist, was often used as an adjuvant drug prior to and during acupuncture anesthesia in clinics, However, its effects was not known clearly. By using potassium iontophoretic dolorimetry and stimulating unilateral "Hegu" and "Waiguan" points with electroacupuncture (EA) in 42 rabbits, we found that Promethazine could drop the pain threshold in small dosages (0.5 mg/kg, 1 mg/kg) and raise the pain threshold in relatively large dosages (2 mg/kg, 4 mg/kg). In different dosages (1 mg/kg, 2 mg/kg), promethazine could attenuate the analgesic effect of EA. It was suggested that promethazine should be used carefully in acupuncture anaesthesia.

Acupuncture Analgesia↗
PubMed1990

[Autoradiographic visualization on the role of central 3H-5-hydroxytryptamine in acupuncture analgesia].

The role played by central 5-hydroxytryptamine (5-HT) in electro-acupuncture analgesia has been studied in rats by means of autoradiography with isotopic tracers 3H-5-HT. The purpose of the present study is to determine the localization of 3H-5-HT in the midbrain raphe nuclei and in the mesencephalon aqueduct as well as periaqueductal gray matter. Parallel experiments were studied by freezing microautoradiographic method and histo-fixative microautoradiographic method. The analgesia effect of acupuncture can be enhanced or lowered by the increment or the decrement of the 5-HT level in the midbrain raphe nuclei and in the mesencephalon aqueduct as well as periaqueductal gray matter. The results of the present experiments show that, when the rats were subjected to electro-acupuncture analgesia. The microautoradiographic intensities of 3H-5-HT both in the midbrain raphe nuclei and in the areas of mesencephalon aqueduct were significantly increased. It may be observed that the release of 5-HT in these regions of the brain is accelerated during acupuncture analgesia. From this it can be concluded that the midbrain raphe nuclei and the mesencephalon aqueduct as well as the periaqueductal gray matter are closely related to acupuncture analgesia. The results imply that 5-HT in these areas may be one of the most important neurochemical agents mediating acupuncture analgesia.

Acupuncture Analgesia↗
PubMed1990

[Study on change in zinc concentration for diabetic cataractous lenses in rats by means of XIXA].

The SD rats were injected with streptozotocin to induce diabetic cataract. Element Zn as well as K, Ca, Mn, Fe, Cu, Pb, Se, etc. in the eye lenses was determined by means of X-ray induced X-fluorescence analysis (XIXA). Compared to values for normal healthy rats, the concentration of Zn and Fe in the cataractous lenses increased, the concentration of K decreased, and that of the others did not change prominently. The change in Zn concentration was probably to meet the needs of the metabolic adjustment in the eye lenses, which would not be the reason for directly inducing diabetic cataract.

Animals↗
PubMed1989

Conservation between coding and regulatory elements of Rhizobium meliloti and Rhizobium leguminosarum dct genes.

Complementation of Rhizobium leguminosarum dct mutants with a cosmid bank yielded Rhizobium meliloti homologs of the dctA, dctB, and dctD genes. The genes dctB and dctD are thought to form a two-component system which responds to the presence of C4-dicarboxylates to regulate expression of a transport protein encoded by dctA. DNA sequence analysis showed that dct coding and intergenic regions, including putative binding sites for the dctD protein and sigma 54-RNA polymerase, were highly conserved between these two Rhizobium species. Mutation of R. meliloti dctD showed that it was not essential for symbiotic nitrogen fixation but was needed for growth on succinate and the expression of a dctA-lacZ fusion gene in free-living cells. Hybridization of R. meliloti genomic DNA with probes representing the central portion of dctD potentially identified more than 20 similar regulatory genes, all of which are likely to depend upon the alternative sigma factor encoded by rpoN and stimulate transcription in a manner very similar to ntrC activation of glnA in enteric bacteria.

Amino Acid Sequence↗
PubMed1989

Phonosurgical studies: fat-graft reconstruction of injured canine vocal cords.

Damage to the vocal cords can result in scarring and impaired vibration and can manifest clinically as hoarseness and loss of vocal power. If the vibratory characteristics could be restored in these scarred vocal cords, the vocal intensity and efficiency of phonation also should improve. In an effort to enhance the vibration of damaged vocal cords, we implanted a submucosal fat autograft within the injured vocal cord cover layer of dogs 6 weeks after unilateral mucosal excision had been performed. Three months postoperatively these animals were compared to normal dogs and those with mucosal excision but no fat-grafting. Acoustic and biomechanical measures of phonation were collected from an excised larynx preparation. We found that the fat-augmented vocal cords had lower threshold pressures for phonation, greater vocal intensity, and more efficient acoustic output than injured vocal cords without the fat-grafting. These results provide a foundation for further research on reconstructive surgery of damaged vocal cords.

Adipose Tissue↗