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Biomedical subjects

J Jerez

Publications and source records attributed to J Jerez.

At least 19 recordsLinked to original sources
PubMed1996

Betahistine-induced bronchospasm.

Betahistine is a cerebral vasodilator structurally related to histamine, which stimulates H1 bronchial and vascular receptors. We report the case of a 28-year-old female patient who presented bronchospasm during treatment with betahistine hydrochloride. The prick test was negative. The oral challenge test showed bronchospasm and urticarial lesions. To the best of our knowledge, this is the first case of betahistine-induced bronchospasm reported in the literature. The study carried out failed to reveal the mechanism of the reaction.

Adult↗
PubMed1980

Lepromatous leprosy and contact dermatitis.

The rare association of lepromatous leprosy and allergic contact dermatitis due to chromium in cement was confirmed clinically and biologically in a male patient. The apparent lack of influence of lepromatous leprosy on the development and maintenance of this dermatitis dependent upon cell-mediated immune mechanisms is discussed.

Adult↗
PubMedDate not supplied

[Etiopathogenesis of atopic dermatitis].

There is a wide variety of criteria in regard to the etiology of atopic dermatitis of neurodermitis. The allergic factor may play a very important role in its etiology. There is neither a general agreement on the importance of food allergy in this regard. Broadly considered, these patients may evoke intense positive reactions to intradermal tests to food and inhalative allergens, nevertheless it will be possible to establish that the lesions appear or disappear after the exposure of suppression of the antigens which evoked the positive reaction. On this basis, many dermatologists deny the allergic etiology in atopic dermatitis, even though in most instances no food skin tests are performed. In this study, 110 patients, both children and adults of both sexes, suffering from atopic dermatitis are investigated. The onset in most of the cases is before the age of six months, following the ages between 1-10 years; the groups between 6 months and one year, and 10-20 years followed a descending order per decade until 70 years. 60.9% of the cases showed food allergy to one or more food items. In 39% of the cases, no food allergy was found. The food-stuffs more commonly involved were: milk (37.7%), egg (26.3%) and fish (20.9%), followed by coca, wheat flour, seafood, fruits, vegetables and meat. A remission of the reaction followed the suppression of the allergen. Intestinal parasitosis is evaluated in relation to atopic dermatitis. 30.9% of the 110 cases were affected with intestinal parasitosis, being the most common the flagelates (lamblias), protozoa (amoeba) and nematodes (ascaris, tricocephalus and oxijrus). Finally, a concurrence is found between atopic dermatitis and other allergic diseases in 81 cases (73.6%), being bronchial asthma and asthmatic bronchitis the most frequent, and allergic rhinitis, urticaria and Quincke's edema less frequent.

Adolescent↗
PubMedDate not supplied

Cell-mediated immunity in healthy and uremic adults assessed by in vivo and in vitro techniques. Validation of delayed hypersensitivity skin testing.

Cell-mediated immunocompetence was assessed in 16 healthy and 10 uremic subjects by "in vivo" and "in vitro" techniques, simultaneously. PHA-induced lymphocyte transformation, Multitest and classical skin testing with a panel of 7 antigens have been used. Similar cutaneous delayed-type hypersensitivity (DTH) results were obtained when using either Multitest or the classical panel, both in healthy subjects (R = 0.66) and in uremic patients (R = 0.61). The results were the same for both the total scores and the number of positive responses per subject. The two DTH methods were of similar accuracy in the evaluation of normal DTH responses and hypoergy in both populations but the sensitivity in detecting anergy among the uremics was higher for the classical panel (80%) than for Multitest (60%). However, no method proved to be more prone to classify a healthy subject as anergic. Anergy was more frequent among uremic patients both with Multitest (60%) and the conventional panel (80%) but was unusual among healthy controls (6.3% and 7.1%, respectively) (p less than 0.0001 for both). Depressed DTH reactivity in uremia was correlated with longer blood transfusion-free intervals (p less than 0.05) and influenced by the duration of haemodyalisis and the number of blood transfusions. Similar CMI impairment rates were found in uremic patients with Multitest (76.9%), the classical panel (63.8%) and "in vitro" techniques (63.7%). Therefore, cutaneous DTH testing proved to be a useful mean of evaluating CMI. Moreover, the high cost and technical complexity of "in vitro" techniques are major drawbacks against their use and strenghthen the role of DTH skin testing as a useful clinical tool to measure CMI.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗